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Entry version 137 (07 Apr 2021)
Sequence version 1 (01 Nov 1997)
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Protein

Versican core protein

Gene

VCAN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCAN
Synonyms:CSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752527 – 3562Versican core proteinAdd BLAST3536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 129By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 242By similarity
Disulfide bondi195 ↔ 216By similarity
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 344By similarity
Disulfide bondi293 ↔ 314By similarity
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1625N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1988N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2089N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2507N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2642N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2762N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3069N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3232N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3258 ↔ 3269By similarity
Disulfide bondi3263 ↔ 3278By similarity
Disulfide bondi3280 ↔ 3289By similarity
Disulfide bondi3296 ↔ 3307By similarity
Disulfide bondi3301 ↔ 3316By similarity
Disulfide bondi3318 ↔ 3327By similarity
Disulfide bondi3334 ↔ 3345By similarity
Disulfide bondi3362 ↔ 3454By similarity
Disulfide bondi3430 ↔ 3446By similarity
Disulfide bondi3461 ↔ 3504By similarity
Disulfide bondi3490 ↔ 3517By similarity
Glycosylationi3545N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90953

PRoteomics IDEntifications database

More...
PRIDEi
Q90953

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Prechondrogenic condensation area of developing limb buds.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Disappears after the cartilage development.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000025144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90953

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 143Ig-like V-typeAdd BLAST117
Domaini149 – 244Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini250 – 346Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3254 – 3290EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3292 – 3328EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3341 – 3455C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3459 – 3519SushiPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRBE, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90953

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEYEEHI

Database of Orthologous Groups

More...
OrthoDBi
74642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90953

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform V0 (identifier: Q90953-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLNIKSIIW MCSTLAITYM LPKVKAEKKT LVKGSLSGTS VLPCFFSTTP
60 70 80 90 100
TIASSYAAEY LRIKWSKVEL DKSGKDAKET TVLVAQNGNI KIGQNYKDRV
110 120 130 140 150
SVPTHSEETG DASLTFSRLR ASDAGVYRCD VMYGVEDTQG IVSLAVDGVV
160 170 180 190 200
FHYRAATSRY TLNFTQAQQT CLDNGAVIAS PEQLKAAYED GFEQCDAGWL
210 220 230 240 250
SDQTVRYPIR HPRIGCFGDK MGKKGVRTYG RRFPNETYDV YCYVEHMQDE
260 270 280 290 300
VVHVSVPEKL TFEEAKELCR KRDGVLASVG NMYVAWRNGF DQCDYGWLAD
310 320 330 340 350
GSVRYPASVA RPQCGGGLLG VRTLYRYENQ TGFPYPDSKF DAYCYERKKI
360 370 380 390 400
VSEPTTVKLV TTLKTDSVEL SSAKVTLKPS VFESSVTEVA VTKTKVPAWE
410 420 430 440 450
EATLETEDTK MTTEVAEEKR EMEVLMENIK LTTLLPQTVT DGEISPYDTL
460 470 480 490 500
GRTEYDVSPR LTESTSAALE VEHTYSEAEL SEEQGRSEST EDAFLTSVVF
510 520 530 540 550
QDSTAVAKSS TGSWEDIETG DTQKHDGDNQ TEQIEVGPVM TATDSLVPAS
560 570 580 590 600
QRELPRTGSS VSLTKENLYL GSHSTKEPTK KSMEAKSDKK LTTVVIPKAL
610 620 630 640 650
FTDQYDLTTG GEGRESMYTV MPDRVSGVAL VSIPESDVPA VSETLMDELA
660 670 680 690 700
VTTGQSSTAD ESTPFIKFSS SATELDNEAS AEGSREDLKD VHLTTSSGIP
710 720 730 740 750
VSFTLFTANE TGSEVTALSE STSAPQKFEE GITSVLHSSQ QTEGSAILEK
760 770 780 790 800
QEKTKEPEMS TIDAKVLYIT TVVPASVTAG SEGRFGSEKF THTPPVSGMW
810 820 830 840 850
LQTDKDQVYM TEETSHTKRI ELDTEDDISG MEPTSSPGQI IEYTKHLGAP
860 870 880 890 900
VSAVTDETKT SMETAETESD EEVVSADFDQ TKGTTEVFHT SSSLDLEKFT
910 920 930 940 950
LSKIPEDESS ATVKSFSSSS GTVLPTAVAT VLEVTDHEAD ETSGYVLNMT
960 970 980 990 1000
FSTPEGEQRK ATEKSPATSA EDEVSTGTEI SKYTMTEGGQ ISSVTSAEKE
1010 1020 1030 1040 1050
SVAALQEREE QPSVGLPETK EPFKFTDVTE IETTVPQREG DTSLVPVTVG
1060 1070 1080 1090 1100
SEDIGEMQVT DHTSFDSIIH TEATVTSTKA SEVFPKELST KDQDRELGTA
1110 1120 1130 1140 1150
MGSTLPVTSV QMHEQKTTAG FESPQTTTQE KHDEMGSAYD EMYPATELSV
1160 1170 1180 1190 1200
PALMLTEYGQ VSGPVETSTR SLHLTGTPKA ETATDQEEKI TEAVPVTFGT
1210 1220 1230 1240 1250
QAKVYESKGT TTREEDRDVG SWNSVLPPHT MLSSPSTAGS ISLLTLGASP
1260 1270 1280 1290 1300
SQTPEGSGIS EELEEVKTVP FSSRATDKTT VISDLTTSSI SAVDKIQPTS
1310 1320 1330 1340 1350
ASKPFVSSKS PRIIPEEDEE VTSSDIIVID ESISPSKASA EDDLTGKMVE
1360 1370 1380 1390 1400
PEIDKEYFTS STATAVARPT APPTVMEATE ALQPQEVSPT SHPDSGTDIR
1410 1420 1430 1440 1450
LYVIQITGND TDHPVNEFLD LFSRHILPHA VDETHTDAES AQTEPCTSDS
1460 1470 1480 1490 1500
VQDSSEYIIL DPFFPNFMDF EEEEEDCENT TDVTTPPALQ FINGKQQVTS
1510 1520 1530 1540 1550
APKSTKAEEA RSDQIESVAH SKNVTFSQIN ETNTFIISET EASGTMQPSK
1560 1570 1580 1590 1600
AGEVMGAFEV TQPTADVAML EPVYSGESEV TTTDKYLEIT SVYEQSPKKN
1610 1620 1630 1640 1650
KETVMWHGTE ESSTKDTKNL LLITNESSGD GSTESDLSRS VFTEILTMSS
1660 1670 1680 1690 1700
HEDSEKISHT TSVPTILSVE RSAVTAAPSA DSDTATVGID VKDLIPKGGT
1710 1720 1730 1740 1750
ATPGNYYKST IKLDAEFPFE SNPEATSHTT KPDMTASSFI VLEGSGDVEE
1760 1770 1780 1790 1800
NSTLASAMTT ETAVAETLSV QDTSLGSGTV LPTEISVTIS EITPALPGGT
1810 1820 1830 1840 1850
RILYSTFDQS SEATVSTNFV SELIMEQVVG SSVATEKKVE DEKEVQTTVY
1860 1870 1880 1890 1900
SSQEISTTDA KGKSELDEFG STTNEVRTVS QEPTPLREIV PITGTMHSEI
1910 1920 1930 1940 1950
KKVTATPFLR EKLFINEGSA EEPADLFAGS PTRKVVSTDS PFTDSGSGDI
1960 1970 1980 1990 2000
DVITESATLT SVPSRSVIET QTVKHEGNIN VISVSLKNTT TEYEEHIGTG
2010 2020 2030 2040 2050
GPVTSVSSTG SDGLTEESEV AIEMSENVFS TENQGEPTQE AVPTYTAPSD
2060 2070 2080 2090 2100
IKSRLGSRRE VTSHVTPVIR TKDLETAEVT SSPESVVNNS TLDTMVTHGT
2110 2120 2130 2140 2150
IRAVAESTES KKGKGSFSAV SLGKILMIEH GSGEELKVDS STTKLMSNGP
2160 2170 2180 2190 2200
TEKLLGSHFS FFDQGSGEAE TLTESFTKAS VSPTGKPEPQ EQYGRKTVSM
2210 2220 2230 2240 2250
PSAVVHAYTA EPNELVTSTE HDITSLQTVT DTEMEEKAAN ELTVTSFATN
2260 2270 2280 2290 2300
LPLSEDVHSW EDRPREILPK AIESSGEATE DPFFISTQAN HEHVEFLSVP
2310 2320 2330 2340 2350
TIRPHSEENK VEAESDEKIL LPFNNDRVTE SAVIERKYLS SPFTDTEQEE
2360 2370 2380 2390 2400
ELVQNIFPTE DIPRLFLTPK EEKPTNNELI SDPLFSGQGS GDEFTVIPSV
2410 2420 2430 2440 2450
ESLAVKETTN TLSPWPFHPA SVGPKLSTDK TQVFESGSTD SNAEINEEIT
2460 2470 2480 2490 2500
TTAAELTETA YSMATSSPAL EEESSSHSNS KDKDITHYFL VIEDPYNKEM
2510 2520 2530 2540 2550
DHRRGENGTS RPLPTPGDVS LEESSHMLTT DDVTPVSVIL SETPYLEMGK
2560 2570 2580 2590 2600
SLATSATKMP SRVLPESSGE GSGWDGVSDS FAPDTLTHST APSVMEVELT
2610 2620 2630 2640 2650
ASSHIPGVYS EVMTTHVPGD GSQTVITGLA SLFTEEKEIV ANRTAADPKT
2660 2670 2680 2690 2700
GTSEELTSDT GMSLDIIPVV DDRRHVTLNV SVYGDITLIE ERLQIPSEKT
2710 2720 2730 2740 2750
TIIDMDHSKS MPEDIISVQT MPNLVIRSTQ VSDDNMKAEE DKYDSILNFS
2760 2770 2780 2790 2800
TVEENSFGSG DNLSLTTSIQ PSSESVTAGH GPKLVDKDLG SGYAMQFATE
2810 2820 2830 2840 2850
TLTTTVLNEL GIFLPTVPSL VSPHMPHESK ESEFEAKHIG RTSTTDDVYE
2860 2870 2880 2890 2900
PYTSANNQVI TDQSKTMSIS GFSGMGQEES GDKKPMIPSL TPDLTMETEK
2910 2920 2930 2940 2950
ALTTDTFDVS MVTTQSMSQH ATVSSSSSEE KHSTVYMQTK SASTEYEETD
2960 2970 2980 2990 3000
SVSLNSVSQN PKSSVTVWLV NGVSKYPEVI IPSTSSAKDS DQSDHSSDGT
3010 3020 3030 3040 3050
FKEVSSDMAA TYKPPTTDLD TTVSSLLVFS PEPESESIST ESTPHFNKFV
3060 3070 3080 3090 3100
TERSEETESS VNDLIIEENA TVSGDSPSIH DYPTAFWNFG ERTSTDVPKL
3110 3120 3130 3140 3150
STIEVEFSSE RVKNPSQESD RSTERERPRL SSAPVSDSPN SIEVGVFKPD
3160 3170 3180 3190 3200
QEAVTMLTSS LEPLDRSLET QSALLGPLLG QQEITTISSN IATNNTAPGN
3210 3220 3230 3240 3250
NPYSNEQSTI SSELLNTIEL VTSSFSLPEV TNGSDFLIGT SVGSVEGTAV
3260 3270 3280 3290 3300
QIPGQDPCKS NPCLNGGTCY PRGSFYICTC LPGFNGEQCE LDIDECQSNP
3310 3320 3330 3340 3350
CRNGATCIDG LNTFTCLCLP SYIGALCEQD TETCDYGWHK FQGQCYKYFA
3360 3370 3380 3390 3400
HRRTWDTAER ECRLQGAHLT SILSHEEQVF VNRIGHDYQW IGLNDKMFER
3410 3420 3430 3440 3450
DFRWTDGSPL QYENWRPNQP DSFFSAGEDC VVIIWHENGQ WNDVPCNYHL
3460 3470 3480 3490 3500
TYTCKKGTVA CGQPPVVENA KTFGKMKPRY EINSLIRYHC KDGFIQRHIP
3510 3520 3530 3540 3550
TIRCQGNGRW DMPKITCMNP STYQRTYSKK YYYKHSSSGK GTSLNSSKHY
3560
HRWIRTWQDS RR
Length:3,562
Mass (Da):388,083
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BC566E88C1602D2
GO
Isoform V1 (identifier: Q90953-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     485-1411: Missing.

Show »
Length:2,635
Mass (Da):288,889
Checksum:i81F4B77F4E299BE4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003093485 – 1411Missing in isoform V1. 1 PublicationAdd BLAST927

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X60226 mRNA Translation: CAA42787.1
D13542 mRNA Translation: BAA02742.1

Protein sequence database of the Protein Information Resource

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PIRi
A47171

NCBI Reference Sequences

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RefSeqi
NP_990118.1, NM_204787.1 [Q90953-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
395565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395565

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60226 mRNA Translation: CAA42787.1
D13542 mRNA Translation: BAA02742.1
PIRiA47171
RefSeqiNP_990118.1, NM_204787.1 [Q90953-1]

3D structure databases

SMRiQ90953
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025144

Proteomic databases

PaxDbiQ90953
PRIDEiQ90953

Genome annotation databases

GeneIDi395565
KEGGigga:395565

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1462

Phylogenomic databases

eggNOGiENOG502QRBE, Eukaryota
InParanoidiQ90953
OMAiTEYEEHI
OrthoDBi74642at2759
PhylomeDBiQ90953

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q90953

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90953
Secondary accession number(s): Q90945
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 7, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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