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Entry version 117 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Protein polybromo-1

Gene

PBRM1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1378 – 1446HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein polybromo-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBRM1
Synonyms:PB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002231861 – 1633Protein polybromo-1Add BLAST1633

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90941

PRoteomics IDEntifications database

More...
PRIDEi
Q90941

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000040734

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90941

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q90941

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 135Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini197 – 267Bromo 2PROSITE-ProRule annotationAdd BLAST71
Domaini398 – 468Bromo 3PROSITE-ProRule annotationAdd BLAST71
Domaini536 – 606Bromo 4PROSITE-ProRule annotationAdd BLAST71
Domaini674 – 744Bromo 5PROSITE-ProRule annotationAdd BLAST71
Domaini790 – 860Bromo 6PROSITE-ProRule annotationAdd BLAST71
Domaini954 – 1072BAH 1PROSITE-ProRule annotationAdd BLAST119
Domaini1155 – 1271BAH 2PROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi357 – 363Poly-Ala7
Compositional biasi629 – 631Poly-Asp3
Compositional biasi1435 – 1543Pro-richAdd BLAST109

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1827, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90941

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90941

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05515, Bromo_polybromo_V, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 6 hits
2.30.30.490, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo

The PANTHER Classification System

More...
PANTHERi
PTHR16062, PTHR16062, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 2 hits
PS00633, BROMODOMAIN_1, 5 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKRRRATS PSSSVSGGDF DDGHHSTNIP GPSRKRRRLS NLPTVDPIAV
60 70 80 90 100
CHELYNTIRD YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS QPIDLMKIQQ
110 120 130 140 150
KLKMEEYDDV NVLTADFQLL FNNAKAYYKP DSPEYKAACK LWELYLRTKN
160 170 180 190 200
EFVQKGDAEE EDEDEEGHDS QELSSPGYLK EILEQLLEAV AVATNPSGRL
210 220 230 240 250
ISELFQKLPS KVQYPDYYAI IKEPIDLKTI AQRIQNGTYK SIHAMAKDID
260 270 280 290 300
LLAKNAKTYN EPGSQVFKDA NAIKKIFNMK KAEIEHSELA KSSLRLRTPS
310 320 330 340 350
NLTASKLTGP SSQGKGSVGD ERNSSNKYFR NKRSAQGDRL SAITMALQYG
360 370 380 390 400
SESDEDAALA AAARYEGESE AESITSFMDT SNPLYQLYDT VRSCRNNQGQ
410 420 430 440 450
LISEPFFQLP SKKKYPDYYQ QIKTPISLQQ IRAKLKNHEY ETLDQLEADL
460 470 480 490 500
NLMFENAKRY NVPNSAIYKR VLKMQQVMQA KKKELARRDD IEDGDSMISS
510 520 530 540 550
ATSDTGSSKR KSKKNMRKQR MKILYNAVLE ARESGTGRRL CDLFMVKPSK
560 570 580 590 600
KDYPDYYKII LEPMDLKMIE HNIRNDKYVG EEAMIDDMKL MFRNARHYNE
610 620 630 640 650
EGSQVYNDAH MLEKILKEKR KELGPLPEDD DVASPKLKLS RKSGISPKKS
660 670 680 690 700
KYMTPMQQKL NEVYEAVKNY TDKRGRRLSA IFLRLPSRSE LPDYYITIKK
710 720 730 740 750
PVDMEKIRSH MMANKYQDID SMVEDFVMMF NNACTYNEPE SLIYKDALVL
760 770 780 790 800
HKVLLETRRE IEGDEDSHVP NVTLLIQELI HNLFVSVMSH QDDEGRCYSD
810 820 830 840 850
SLAEIPAVDP NFPNKPPLTF DIIRKNVENN RYRRLDLFQE NMFEVLERAR
860 870 880 890 900
RMNRTDSEIY EDAVELQQFF IKIRDELCKN GEILLSPALS YTTKHLHNDV
910 920 930 940 950
EKEKKEKLPK EIEEDKLKRE EEKREAEKSE DSSGSAGLSS LHRTYSQDCS
960 970 980 990 1000
FKNSMYHVGD YVYVEPAEAN LQPHIVCIER LWEDSAGEKW LYGCWFYRPN
1010 1020 1030 1040 1050
ETFHLATRKF LEKEVFKSDY YNKVPVSKIL GKCVVMFVKE YFKLCPENFR
1060 1070 1080 1090 1100
DEDVYVCESR YSAKTKSFKK IKLWTMPVSS VRFVPRDVPL PVVRVASVFA
1110 1120 1130 1140 1150
NTDKAEEEKH SDTLDDSKVG ESILHLEKDK EDVPVEMSNG EPGCHYFEQL
1160 1170 1180 1190 1200
CYNDMWLKVG DCVFIKSHGL VRPRVGRIEK MWVRDGAAYF FGPIFIHPEE
1210 1220 1230 1240 1250
TEHEPTKMFY KKEVFLSNLE ETCPMSCILG KCAVLSFKDF LCCRPTEISE
1260 1270 1280 1290 1300
NDVFLCESRY NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP
1310 1320 1330 1340 1350
SPLLEKKIQQ LEAKFAELGG GDEDMEEMGE EEGDITETPS MPQLQTPLTS
1360 1370 1380 1390 1400
ELDIMPYTPP QSTPKSVKGS TKKEGSKRKI NMSGYILFSS EMRPVIKAQH
1410 1420 1430 1440 1450
PDYSFGELSR LVGTEWRNLE ATKKAEYEGM ISGYPPVLPP LQGPVDGIVS
1460 1470 1480 1490 1500
MGSMQPLHPG VPPPHQLPPG MPGIPGIPPP GVIGQNVSPM VGTPAPGAGP
1510 1520 1530 1540 1550
FGQQIGILGP PGQQAPPPYP GQSPATQPVM QQPSTPMFVS PPPKTQRLLH
1560 1570 1580 1590 1600
SEAYLKYIEG LSAESNSISK WDQTLAARRR DVHLSKEQES RLPSHWLKSK
1610 1620 1630
GAHTTMADAL WRLRDLMLRD TLNIRQAYNI ENV
Length:1,633
Mass (Da):187,055
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4CA350E1087F888
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X90849 mRNA Translation: CAA62353.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5056

NCBI Reference Sequences

More...
RefSeqi
NP_990496.1, NM_205165.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396074

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90849 mRNA Translation: CAA62353.1
PIRiJC5056
RefSeqiNP_990496.1, NM_205165.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W4SX-ray1.55A932-1103[»]
SMRiQ90941
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040734

Proteomic databases

PaxDbiQ90941
PRIDEiQ90941

Genome annotation databases

GeneIDi396074
KEGGigga:396074

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55193

Phylogenomic databases

eggNOGiKOG1827, Eukaryota
InParanoidiQ90941
PhylomeDBiQ90941

Miscellaneous databases

EvolutionaryTraceiQ90941

Protein Ontology

More...
PROi
PR:Q90941

Family and domain databases

CDDicd05515, Bromo_polybromo_V, 1 hit
Gene3Di1.20.920.10, 6 hits
2.30.30.490, 2 hits
InterProiView protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo
PANTHERiPTHR16062, PTHR16062, 2 hits
PfamiView protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits
PROSITEiView protein in PROSITE
PS51038, BAH, 2 hits
PS00633, BROMODOMAIN_1, 5 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPB1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90941
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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