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Entry version 124 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Netrin-3

Gene

NTN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin-3
Alternative name(s):
Netrin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTN3
Synonyms:NTN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei‹1 – 15Sequence analysisAdd BLAST›15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001708716 – 581Netrin-3Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 124By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi264 ↔ 281By similarity
Disulfide bondi283 ↔ 292By similarity
Disulfide bondi295 ↔ 315By similarity
Disulfide bondi318 ↔ 327By similarity
Disulfide bondi320 ↔ 345By similarity
Disulfide bondi348 ↔ 357By similarity
Disulfide bondi360 ↔ 378By similarity
Disulfide bondi381 ↔ 393By similarity
Disulfide bondi383 ↔ 400By similarity
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi402 ↔ 411By similarity
Disulfide bondi414 ↔ 428By similarity
Disulfide bondi449 ↔ 521By similarity
Disulfide bondi468 ↔ 578By similarity
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000043056

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90923

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 261Laminin N-terminalPROSITE-ProRule annotationAdd BLAST227
Domaini262 – 317Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini318 – 380Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini381 – 430Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50
Domaini449 – 578NTRPROSITE-ProRule annotationAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi507 – 509Cell attachment siteSequence analysis3

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3512, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90923

Database of Orthologous Groups

More...
OrthoDBi
858946at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90923

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q90923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LRLLLTTSVL RLARAANPFV AQQTPPDPCY DESGAPRRCI PEFVNAAFGK
60 70 80 90 100
EVQASSTCGK PPTRHCDASD PRRAHPPAYL TDLNTAANMT CWRSETLHHL
110 120 130 140 150
PHNVTLTLSL GKKFEVVYVS LQFCSPRPES TAIFKSMDYG KTWVPYQYYS
160 170 180 190 200
SQCRKIYGKP SKATVTKQNE QEALCTDGLT DLYPLTGGLI AFSTLDGRPS
210 220 230 240 250
AQDFDSSPVL QDWVTATDIR VVFSRPHLFR ELGGREAGEE DGGAGATPYY
260 270 280 290 300
YSVGELQVGG RCKCNGHASR CVKDKEQKLV CDCKHNTEGP ECDRCKPFHY
310 320 330 340 350
DRPWQRASAR EANECLACNC NLHARRCRFN MELYKLSGRK SGGVCLNCRH
360 370 380 390 400
NTAGRHCHYC KEGFYRDLSK SITDRKACKA CDCHPVGAAG KTCNQTTGQC
410 420 430 440 450
PCKDGVTGLT CNRCAKGFQQ SRSPVAPCIK IPAINPTSLV TSTEAPADCD
460 470 480 490 500
SYCKPAKGNY KINMKKYCKK DYVVQVNILE METVANWAKF TINILSVYKC
510 520 530 540 550
RDERVKRGDN FLWIHLKDLS CKCPKIQISK KYLVMGISEN STDRPGLMAD
560 570 580
KNSLVIQWRD AWTRRLRKLQ RREKKGKCVK P
Length:581
Mass (Da):65,107
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AE59387A5F44659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L34550 mRNA Translation: AAA61743.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B54665

NCBI Reference Sequences

More...
RefSeqi
NP_001264534.1, NM_001277605.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396387

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396387

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34550 mRNA Translation: AAA61743.1
PIRiB54665
RefSeqiNP_001264534.1, NM_001277605.1

3D structure databases

SMRiQ90923
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000043056

Proteomic databases

PaxDbiQ90923

Genome annotation databases

GeneIDi396387
KEGGigga:396387

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4917

Phylogenomic databases

eggNOGiKOG3512, Eukaryota
InParanoidiQ90923
OrthoDBi858946at2759
PhylomeDBiQ90923

Family and domain databases

Gene3Di2.40.50.120, 1 hit
2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNET3_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90923
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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