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Protein

Netrin-3

Gene

NTN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons.

GO - Biological processi

  • myoblast fusion Source: MGI
  • regulation of transcription, DNA-templated Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-3
Alternative name(s):
Netrin-2
Gene namesi
Name:NTN3
Synonyms:NTN2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 15Sequence analysisAdd BLAST›15
ChainiPRO_000001708716 – 581Netrin-3Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 124By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi264 ↔ 281By similarity
Disulfide bondi283 ↔ 292By similarity
Disulfide bondi295 ↔ 315By similarity
Disulfide bondi318 ↔ 327By similarity
Disulfide bondi320 ↔ 345By similarity
Disulfide bondi348 ↔ 357By similarity
Disulfide bondi360 ↔ 378By similarity
Disulfide bondi381 ↔ 393By similarity
Disulfide bondi383 ↔ 400By similarity
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi402 ↔ 411By similarity
Disulfide bondi414 ↔ 428By similarity
Disulfide bondi449 ↔ 521By similarity
Disulfide bondi468 ↔ 578By similarity
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90923
PRIDEiQ90923

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014976

Structurei

3D structure databases

ProteinModelPortaliQ90923
SMRiQ90923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 261Laminin N-terminalPROSITE-ProRule annotationAdd BLAST227
Domaini262 – 317Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini318 – 380Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini381 – 430Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50
Domaini449 – 578NTRPROSITE-ProRule annotationAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi507 – 509Cell attachment siteSequence analysis3

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512 Eukaryota
ENOG410XS7U LUCA
HOGENOMiHOG000286017
HOVERGENiHBG006464
InParanoidiQ90923
KOiK06843
PhylomeDBiQ90923

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF00055 Laminin_N, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00180 EGF_Lam, 3 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 3 hits
PS51117 LAMININ_NTER, 1 hit
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LRLLLTTSVL RLARAANPFV AQQTPPDPCY DESGAPRRCI PEFVNAAFGK
60 70 80 90 100
EVQASSTCGK PPTRHCDASD PRRAHPPAYL TDLNTAANMT CWRSETLHHL
110 120 130 140 150
PHNVTLTLSL GKKFEVVYVS LQFCSPRPES TAIFKSMDYG KTWVPYQYYS
160 170 180 190 200
SQCRKIYGKP SKATVTKQNE QEALCTDGLT DLYPLTGGLI AFSTLDGRPS
210 220 230 240 250
AQDFDSSPVL QDWVTATDIR VVFSRPHLFR ELGGREAGEE DGGAGATPYY
260 270 280 290 300
YSVGELQVGG RCKCNGHASR CVKDKEQKLV CDCKHNTEGP ECDRCKPFHY
310 320 330 340 350
DRPWQRASAR EANECLACNC NLHARRCRFN MELYKLSGRK SGGVCLNCRH
360 370 380 390 400
NTAGRHCHYC KEGFYRDLSK SITDRKACKA CDCHPVGAAG KTCNQTTGQC
410 420 430 440 450
PCKDGVTGLT CNRCAKGFQQ SRSPVAPCIK IPAINPTSLV TSTEAPADCD
460 470 480 490 500
SYCKPAKGNY KINMKKYCKK DYVVQVNILE METVANWAKF TINILSVYKC
510 520 530 540 550
RDERVKRGDN FLWIHLKDLS CKCPKIQISK KYLVMGISEN STDRPGLMAD
560 570 580
KNSLVIQWRD AWTRRLRKLQ RREKKGKCVK P
Length:581
Mass (Da):65,107
Last modified:November 1, 1996 - v1
Checksum:i4AE59387A5F44659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34550 mRNA Translation: AAA61743.1
PIRiB54665
RefSeqiNP_001264534.1, NM_001277605.1
UniGeneiGga.792

Genome annotation databases

GeneIDi396387
KEGGigga:396387

Similar proteinsi

Entry informationi

Entry nameiNET3_CHICK
AccessioniPrimary (citable) accession number: Q90923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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