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Protein

Interferon regulatory factor 1

Gene

IRF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 113IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 1
Short name:
IRF-1
Gene namesi
Name:IRF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545481 – 313Interferon regulatory factor 1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-271. Sumoylation is enhanced by PIAS3. Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (By similarity).By similarity
Ubiquitinated. Appears to compete with sumoylation on C-terminal sites (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ90876

Expressioni

Gene expression databases

BgeeiENSGALG00000006785 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ90876 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002242

Structurei

3D structure databases

ProteinModelPortaliQ90876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IER3 Eukaryota
ENOG4111HM7 LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037937
HOVERGENiHBG003455
InParanoidiQ90876
KOiK09444
OMAiCKEEPEV
OrthoDBiEOG091G0CB8
PhylomeDBiQ90876

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR031215 IRF1
IPR017431 IRF1/IRF2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF3 PTHR11949:SF3, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PIRSFiPIRSF038196 IFN_RF1/2, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVSRMRMRP WLEMQINSNQ IPGLIWINKD KMIFQIPWKH AAKHGWDMEK
60 70 80 90 100
DACLFRSWAI HTGRYKVGEK DPDPKTWKAN FRCAMNSLPD IEEVKDKSIN
110 120 130 140 150
KGSSAVRVYR MLPPLTKDQK KERKSKSSRE ARNKSKRKLY EDMRMEESAE
160 170 180 190 200
RLTSTPLPDD HSSYTAHDYT GQEVEVENTS ITLDLSSCEV SGSLTDWRMP
210 220 230 240 250
MEIAMADSTN DIYQLQVSPL GSSSEDEDEM KSNIIKLLEP TQDWHTTSVE
260 270 280 290 300
GKGFFTNEPG TQTMCSTFGY KEQDGEIDTS SAELEFRMMD QKSSLDFSWL
310
DTVRPMQAIS CSL
Length:313
Mass (Da):36,010
Last modified:November 1, 1997 - v1
Checksum:i0895FA3736FA7463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39766 mRNA Translation: AAA62160.1
AJ621385 Genomic DNA Translation: CAF18545.1
RefSeqiNP_990746.1, NM_205415.1
UniGeneiGga.791

Genome annotation databases

EnsembliENSGALT00000002244; ENSGALP00000002242; ENSGALG00000006785
GeneIDi396384
KEGGigga:396384

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39766 mRNA Translation: AAA62160.1
AJ621385 Genomic DNA Translation: CAF18545.1
RefSeqiNP_990746.1, NM_205415.1
UniGeneiGga.791

3D structure databases

ProteinModelPortaliQ90876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002242

Proteomic databases

PaxDbiQ90876

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002244; ENSGALP00000002242; ENSGALG00000006785
GeneIDi396384
KEGGigga:396384

Organism-specific databases

CTDi3659

Phylogenomic databases

eggNOGiENOG410IER3 Eukaryota
ENOG4111HM7 LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037937
HOVERGENiHBG003455
InParanoidiQ90876
KOiK09444
OMAiCKEEPEV
OrthoDBiEOG091G0CB8
PhylomeDBiQ90876

Miscellaneous databases

PROiPR:Q90876

Gene expression databases

BgeeiENSGALG00000006785 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ90876 baseline and differential

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR031215 IRF1
IPR017431 IRF1/IRF2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF3 PTHR11949:SF3, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PIRSFiPIRSF038196 IFN_RF1/2, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRF1_CHICK
AccessioniPrimary (citable) accession number: Q90876
Secondary accession number(s): Q5W4T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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