UniProtKB - Q90871 (IRF8_CHICK)
Protein
Interferon regulatory factor 8
Gene
IRF8
Organism
Gallus gallus (Chicken)
Status
Functioni
Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 7 – 114 | IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST | 108 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cellular response to interferon-gamma Source: UniProtKB
- cellular response to lipopolysaccharide Source: Ensembl
- defense response to bacterium Source: Ensembl
- defense response to protozoan Source: Ensembl
- dendritic cell differentiation Source: UniProtKB
- immune response Source: UniProtKB
- immune system process Source: GO_Central
- myeloid cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- phagocytosis Source: Ensembl
- plasmacytoid dendritic cell differentiation Source: UniProtKB
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of type I interferon production Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon regulatory factor 8CuratedShort name: IRF-8 Alternative name(s): Interferon consensus sequence-binding protein1 Publication Short name: ICSBP1 Publication |
Gene namesi | Name:IRF8 Synonyms:ICSBP1 Publication, ICSBP1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154566 | 1 – 425 | Interferon regulatory factor 8Add BLAST | 425 |
Proteomic databases
PaxDbi | Q90871 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000005757, Expressed in spleen and 13 other tissues |
ExpressionAtlasi | Q90871, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the IRF family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | ENOG502QT9P, Eukaryota |
GeneTreei | ENSGT00940000158140 |
HOGENOMi | CLU_031544_1_1_1 |
InParanoidi | Q90871 |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q90871 |
TreeFami | TF328512 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q90871-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDRNGGRRL RQWLIEQIDS EQYPGLIWEN EEKTMFRIPW KHAGKQDYNQ
60 70 80 90 100
EVDASIFKAW AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ
110 120 130 140 150
LDISEPYKVY RIVPEEEQKC KIGVGNGSSL TDVGDMDCSP SAIDDLMKEP
160 170 180 190 200
PCVDEYLGII KRSPSPPQET CRNPPIPDWW MQQPSPSLPL VNGYTGYEQH
210 220 230 240 250
HSGYSQMVIT FFYSGRLVGH ITTSYPEGCR LSLSQPSNHG EKLYTPDSLE
260 270 280 290 300
HVRFPSAEAI QNDRQKQITK KLFGHLERGV LLHSNKQGIF IKRLCQGRVF
310 320 330 340 350
WSGNTVVYKD RPSKLDRDEV VKIFDTNLFF RELQQYYNNQ GRFPDSRVML
360 370 380 390 400
CFGEEFPDTV PLRCKLILVQ VEQLCVRQVM EEAGKTCSSP MLPDDVQQEQ
410 420
VYRIFQDICG PHQRPLFREN QQIAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39767 mRNA Translation: AAA62159.1 |
RefSeqi | NP_990747.1, NM_205416.1 XP_015148037.1, XM_015292551.1 XP_015148038.1, XM_015292552.1 XP_015148039.1, XM_015292553.1 |
Genome annotation databases
Ensembli | ENSGALT00000009243; ENSGALP00000009229; ENSGALG00000005757 |
GeneIDi | 396385 |
KEGGi | gga:396385 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39767 mRNA Translation: AAA62159.1 |
RefSeqi | NP_990747.1, NM_205416.1 XP_015148037.1, XM_015292551.1 XP_015148038.1, XM_015292552.1 XP_015148039.1, XM_015292553.1 |
3D structure databases
SMRi | Q90871 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000009229 |
Proteomic databases
PaxDbi | Q90871 |
Genome annotation databases
Ensembli | ENSGALT00000009243; ENSGALP00000009229; ENSGALG00000005757 |
GeneIDi | 396385 |
KEGGi | gga:396385 |
Organism-specific databases
CTDi | 3394 |
Phylogenomic databases
eggNOGi | ENOG502QT9P, Eukaryota |
GeneTreei | ENSGT00940000158140 |
HOGENOMi | CLU_031544_1_1_1 |
InParanoidi | Q90871 |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q90871 |
TreeFami | TF328512 |
Miscellaneous databases
PROi | PR:Q90871 |
Gene expression databases
Bgeei | ENSGALG00000005757, Expressed in spleen and 13 other tissues |
ExpressionAtlasi | Q90871, baseline and differential |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IRF8_CHICK | |
Accessioni | Q90871Primary (citable) accession number: Q90871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families