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Protein

Hepatocyte nuclear factor 1-alpha

Gene

HNF1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi202 – 282Homeobox; HNF1-typePROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 1-alpha
Short name:
HNF-1-alpha
Short name:
HNF-1A
Alternative name(s):
Transcription factor 1
Short name:
TCF-1
Gene namesi
Name:HNF1A
Synonyms:TCF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491181 – 634Hepatocyte nuclear factor 1-alphaAdd BLAST634

Proteomic databases

PaxDbiQ90867
PRIDEiQ90867

Expressioni

Tissue specificityi

Expressed in liver and in oviduct.

Interactioni

Subunit structurei

Binds DNA as a dimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037563

Structurei

3D structure databases

ProteinModelPortaliQ90867
SMRiQ90867
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 31DimerizationBy similarityAdd BLAST31
Regioni133 – 135Interaction with DNABy similarity3
Regioni146 – 152Interaction with DNABy similarity7
Regioni158 – 161Interaction with DNABy similarity4
Regioni206 – 209Interaction with DNABy similarity4
Regioni266 – 268Interaction with DNABy similarity3
Regioni273 – 276Interaction with DNABy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi200 – 208Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 83Asp/Glu-rich (acidic; potential involvement with transcription)10
Compositional biasi334 – 337Poly-Ser4
Compositional biasi594 – 597Poly-Ser4

Sequence similaritiesi

Belongs to the HNF1 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410IFA0 Eukaryota
ENOG410ZZZ0 LUCA
HOGENOMiHOG000015305
HOVERGENiHBG005980
InParanoidiQ90867
PhylomeDBiQ90867

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR039066 HNF-1
IPR006899 HNF-1_N
IPR023219 HNF1_dimer_N_dom_sf
IPR006898 HNF1a_C
IPR006897 HNF1b_C
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PANTHERiPTHR11568 PTHR11568, 1 hit
PfamiView protein in Pfam
PF04814 HNF-1_N, 1 hit
PF04813 HNF-1A_C, 1 hit
PF04812 HNF-1B_C, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF100957 SSF100957, 1 hit
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q90867-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSKLSHLQV ELLGALLESG LTKETLIKGL SEAEPYVLQS ESQHAINALQ
60 70 80 90 100
TEKGESCPEI PNLPNGMGET RLSEDETSDD GEEFTPPIMK ELENLSPEEA
110 120 130 140 150
AHQKAVVERL LQEDPWRVAK MVKSYLQQHN IPQREVVDTT GLNQSHLSQH
160 170 180 190 200
LNKGTPMKTQ KRAALYTWYV RKQREVAQQF THAGQGILTE EPMGDDLPTK
210 220 230 240 250
KGRRNRFKWG PASQQILFQA YERQKNPSKE EREALVEECN RAECIQRGVS
260 270 280 290 300
PSQAQGLGSN LVTEVRVYNW FANRRKEEAF RHKLAMDNFS GPQPTSAPPL
310 320 330 340 350
TPHNSSSLQP PPALSPTKVH GVRYNQQPAS EAESSSSNHH GNSSMVTTQT
360 370 380 390 400
ILHQVSPPGL EPSQNLLSTD TKLISAPGGT LPPVSTLTAL HSLEQNPHAL
410 420 430 440 450
GQQTQNLIMA SLPGVMAIGA GETSSLAPRF TNTGGSTLVI GLTSTQPQSV
460 470 480 490 500
PVINSMGSSL TTLQPVQFSQ QLHPSYQQPL MQQVQSHINQ SPFMATMAQI
510 520 530 540 550
QNPHALYGPK SEVAQYTHTG LLPQTMVITD TANLSALTNL TPTKQAFTSD
560 570 580 590 600
SETHTDSGIH TPVSQAPAIH LQNQDTAIQH LQSGPRLTPS PAVSSSSLVL
610 620 630
YQSSDSTNSH SQLLPSTHNV IETFISTQMA SSTQ
Length:634
Mass (Da):69,189
Last modified:November 1, 1996 - v1
Checksum:iA1CA1C4A15410919
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1RPG1A0A1L1RPG1_CHICK
Hepatocyte nuclear factor 1-alpha
HNF1A
634Annotation score:
E1BQ64E1BQ64_CHICK
Hepatocyte nuclear factor 1-alpha
HNF1A
609Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67689, X67690 Genomic DNA Translation: CAA47920.1
PIRiS35574

Similar proteinsi

Entry informationi

Entry nameiHNF1A_CHICK
AccessioniPrimary (citable) accession number: Q90867
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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