UniProtKB - Q90837 (ERG_CHICK)
Protein
Transcriptional regulator Erg
Gene
ERG
Organism
Gallus gallus (Chicken)
Status
Functioni
Acts as a transcriptional activator.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 310 – 390 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulator Erg |
Gene namesi | Name:ERG |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204105 | 1 – 478 | Transcriptional regulator ErgAdd BLAST | 478 |
Proteomic databases
PaxDbi | Q90837 |
Expressioni
Tissue specificityi
Expressed in mesoderm- and, to a lesser extent, in ectoderm-derived tissues.
Gene expression databases
Bgeei | ENSGALG00000016058, Expressed in lung and 11 other tissues |
ExpressionAtlasi | Q90837, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 113 – 199 | PNTPROSITE-ProRule annotationAdd BLAST | 87 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160662 |
HOGENOMi | CLU_045216_0_1_1 |
InParanoidi | Q90837 |
OMAi | TWTSHSH |
PhylomeDBi | Q90837 |
TreeFami | TF350537 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q90837-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTIKEALS VVSEDQSLFE CAYGSPHLAK TEMTASSSSE YGQTSKMSPR
60 70 80 90 100
VPQQDWLSQP PARVTIKMEC NPNQVNGSRN SPDDCSVAKG GKMVSSSDNV
110 120 130 140 150
GMNYGSYMEE KHIPPPNMTT NERRVIVPAD PTLWSTDHVR QWLEWAVKEY
160 170 180 190 200
GLPDVDILLF QNIDGKELCK MTKDDFQRLT PSYNADILLS HLHYLRETPL
210 220 230 240 250
PHLTSDDVDK ALQNSPRLMH ARNTGGATFI FPNTSVYPEA TQRITTRPDL
260 270 280 290 300
PYEQARRSAW TSHSHPTQSK ATQPSSSTVP KTEDQRPQLD PYQILGPTSS
310 320 330 340 350
RLANPGSGQI QLWQFLLELL SDSSNSNCIT WEGTNGEFKM TDPDEVARRW
360 370 380 390 400
GERKSKPNMN YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP
410 420 430 440 450
HPPESSMYKY PSDLPYMSSY HAHPQKMNFV APHPPALPVT SSSFFAAPNP
460 470
YWNSPTGGIY PNTRLPAAHM PSHLGTYY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5P6W0 | A0A1D5P6W0_CHICK | Transcriptional regulator Erg | ERG | 485 | Annotation score: | ||
Q8UUU0 | Q8UUU0_CHICK | Erg isoform C-1-1 | ERG | 451 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77159 mRNA Translation: CAA54404.1 |
PIRi | S60754 |
RefSeqi | NP_989611.1, NM_204280.1 |
Genome annotation databases
Ensembli | ENSGALT00000053128; ENSGALP00000049471; ENSGALG00000016058 |
GeneIDi | 374146 |
KEGGi | gga:374146 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77159 mRNA Translation: CAA54404.1 |
PIRi | S60754 |
RefSeqi | NP_989611.1, NM_204280.1 |
3D structure databases
BMRBi | Q90837 |
SMRi | Q90837 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000029713 |
Proteomic databases
PaxDbi | Q90837 |
Genome annotation databases
Ensembli | ENSGALT00000053128; ENSGALP00000049471; ENSGALG00000016058 |
GeneIDi | 374146 |
KEGGi | gga:374146 |
Organism-specific databases
CTDi | 2078 |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160662 |
HOGENOMi | CLU_045216_0_1_1 |
InParanoidi | Q90837 |
OMAi | TWTSHSH |
PhylomeDBi | Q90837 |
TreeFami | TF350537 |
Miscellaneous databases
PROi | PR:Q90837 |
Gene expression databases
Bgeei | ENSGALG00000016058, Expressed in lung and 11 other tissues |
ExpressionAtlasi | Q90837, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERG_CHICK | |
Accessioni | Q90837Primary (citable) accession number: Q90837 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families