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Entry version 102 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein patched homolog 1

Gene

PTCH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein patched homolog 1
Short name:
PTC
Short name:
PTC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTCH1
Synonyms:PTC, PTCH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 101CytoplasmicSequence analysisAdd BLAST101
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 436ExtracellularSequence analysisAdd BLAST314
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 472CytoplasmicSequence analysisAdd BLAST15
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 501ExtracellularSequence analysis8
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 547CytoplasmicSequence analysisAdd BLAST25
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 577ExtracellularSequence analysis9
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 747CytoplasmicSequence analysisAdd BLAST149
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 1026ExtracellularSequence analysisAdd BLAST258
Transmembranei1027 – 1047HelicalSequence analysisAdd BLAST21
Topological domaini1048 – 1053CytoplasmicSequence analysis6
Transmembranei1054 – 1074HelicalSequence analysisAdd BLAST21
Topological domaini1075 – 1082ExtracellularSequence analysis8
Transmembranei1083 – 1101HelicalSequence analysisAdd BLAST19
Topological domaini1102 – 1120CytoplasmicSequence analysisAdd BLAST19
Transmembranei1121 – 1141HelicalSequence analysisAdd BLAST21
Topological domaini1142 – 1153ExtracellularSequence analysisAdd BLAST12
Transmembranei1154 – 1174HelicalSequence analysisAdd BLAST21
Topological domaini1175 – 1442CytoplasmicSequence analysisAdd BLAST268

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002059661 – 1442Protein patched homolog 1Add BLAST1442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi874N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation is necessary for SHH binding.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90693

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is seen in the embryonic neural tube, sclerotome, visceral mesoderm, and limb bud.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In stage 10 embryo, expression is seen in neural tube, and at lower levels in the notochord, epithelial somites, endoderm and splanchnic mesoderm. At stage 18, PTC is broadly expressed in the neural tube but excluded from the cells of the floor plate. At stage 32, expression occurs in the mesodermal cells of the gastrointestinal tract.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated by hedgehog; repressed by itself.Curated

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61762N

Protein interaction database and analysis system

More...
IntActi
Q90693, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000020572

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 598SSDPROSITE-ProRule annotationAdd BLAST161

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the patched family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1935, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90693

Database of Orthologous Groups

More...
OrthoDBi
1190129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90693

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD
IPR004766, TM_rcpt_patched

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460, Patched, 1 hit
PF12349, Sterol-sensing, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00918, 2A060602, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90693-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAADALEP ESGSSTAGGG SHPVRAARSA RGRRRRSGGT RRAAAPDREY
60 70 80 90 100
LQRPSYCDAA FALEQIAKGR ATGRRAPLWL RAKFQRLLFN LGCYIQKNCG
110 120 130 140 150
KFLVVGLLYS AFAVGLRAAN LETNVEELWV EVGGRVSREL NYTRQKIGEE
160 170 180 190 200
AMFNPQLMIQ TPQEDGTNVL TTEALRQHLD SALQASRVHV YMYNRQWKLE
210 220 230 240 250
HLCYKSGELI TEAGYMDQII EYLYPCLIIT PLDCFWEGAK LQSGTAYLLG
260 270 280 290 300
KPPLQWINFD PLEFLEELKK INYQVESWEE MLNKAEVGHG YMDRPCLNPA
310 320 330 340 350
DPDCPITAPN KNSTKPLDVA LVLSGGCYGL SRKYMHWQEE LIIGGTVKNS
360 370 380 390 400
SGKLVSAQAL QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ
410 420 430 440 450
RMYVEVVHQS VAQNSTQKVL SFTTTTLDDI LKSFSDVSVI RVASGYLLML
460 470 480 490 500
AYACLTMLRW DCAKSQGAVG LAGVLLVALS VAAGLGLCSL IGISFNAATT
510 520 530 540 550
QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC LKRTGASVAL
560 570 580 590 600
TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL
610 620 630 640 650
YRREDRRLDI FCCFTSPCVT RVIQIEPQAY AENDNICYSS PPPYSSHSFA
660 670 680 690 700
HETQITMQST VQLRTEYDPH TQAYYTTAEP RSEISVQPVT VTQDSLSCQS
710 720 730 740 750
PESASSTRDL LSQFSDSSVH CLEPPCTKWT LSTFAEKHYA PFLLKPKAKV
760 770 780 790 800
VVIFLFLGLL GLSLYGTTRV RDGLDLTDIV PRDTREYDFI AAQFKYFSFY
810 820 830 840 850
NMYIVTQKAD YPNVQHLLYE LHRSFSNVTY VLLEGDRQLP KMWLHYFRDW
860 870 880 890 900
LQGLQDAFDS DWETGKITYS NYKNGSDDAV LAYKLLVQTG NRAKPIDISQ
910 920 930 940 950
LTKQRLVDAD GIINPNAFYI YLTAWVSNDP VAYAASQANI RPHRPEWVHD
960 970 980 990 1000
KADYMPETRL RIPAAEPIEY AQFPFYLNGL RETSDFVEAI EKVRAICNNY
1010 1020 1030 1040 1050
TSLGIASYPN GYPFLFWEQY IGLRHWLLLS ISVVLACTFL VCALFLLNPW
1060 1070 1080 1090 1100
TAGIIVVVLA LMTVELFGMM GLIGIKLSAV PVVILIASVG IGVEFTVHIA
1110 1120 1130 1140 1150
LAFLTAIGDK NRRAVLALEH MFAPVLDGAV STLLGVLMLA GSEFDFIVRY
1160 1170 1180 1190 1200
FFAVLAILTI LGVLNGLVLL PVLLSFFGPY PEVSPACGRN RLPTPSPEPP
1210 1220 1230 1240 1250
PSIVRFALPP GHTNNGSDSS DSEYSSQTTV SGISEELHHY EATQSPGIPV
1260 1270 1280 1290 1300
HQVVVEATEN PVFARSTVVQ PESRHQSSPR LQSNPEAGTQ QVWHQGRQPK
1310 1320 1330 1340 1350
QEVREGLRPP PYRPRRDAFE ISTEGHSGPS NKDRLNHKAH SHNMRSPAFG
1360 1370 1380 1390 1400
AMGVPGSAYC QPITTVTASA SVTVAVHPAV HSHNSCRGSF PSCEEYNEDD
1410 1420 1430 1440
RGMFEDPHVP FNVRCERRNS KVEVIELQDV ECEERTAGKI SE
Length:1,442
Mass (Da):160,578
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i973E5F17FB8B6E43
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U40074 mRNA Translation: AAC59898.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18538

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40074 mRNA Translation: AAC59898.1
PIRiT18538

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61762N
IntActiQ90693, 1 interactor
STRINGi9031.ENSGALP00000020572

Proteomic databases

PaxDbiQ90693

Phylogenomic databases

eggNOGiKOG1935, Eukaryota
InParanoidiQ90693
OrthoDBi1190129at2759
PhylomeDBiQ90693

Family and domain databases

InterProiView protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD
IPR004766, TM_rcpt_patched
PfamiView protein in Pfam
PF02460, Patched, 1 hit
PF12349, Sterol-sensing, 1 hit
TIGRFAMsiTIGR00918, 2A060602, 1 hit
PROSITEiView protein in PROSITE
PS50156, SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTC1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90693
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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