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Protein
Submitted name:

Synemin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SyneminImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q90662

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 314IF rodInterPro annotationAdd BLAST304

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 49Sequence analysisAdd BLAST35
Coiled coili61 – 95Sequence analysisAdd BLAST35
Coiled coili110 – 137Sequence analysisAdd BLAST28
Coiled coili183 – 285Sequence analysisAdd BLAST103

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154476

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008974

KEGG Orthology (KO)

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KOi
K10376

Database of Orthologous Groups

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OrthoDBi
104920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90662

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRRWEAGWD EKRELQELNS RLRFSVSRVR ELEEENRFLA RELAELREQE
60 70 80 90 100
LIGLRVPEQE LAWLRMQLEE LSQAKLEAEL ERDGLRRELE QLQLLGAEVL
110 120 130 140 150
ATRRRLEPEL AGQRQLLQRL QGECVALEEL LLQLQDEHGH LAERQRREVV
160 170 180 190 200
EIRELRMDLA ALPPPLSALS LEELEETYEM LLSQSCQETL LRYQEQIQRL
210 220 230 240 250
QEQEAQRSRE NLELLREESR QCRQHLEDLH RQGQELCGLR ERLEQELLAM
260 270 280 290 300
QDRHGAEVEE YQRIIDALEE EKQFLTMSIT DYLRDYQELL QVKAGLILEI
310 320 330 340 350
ETYRALLEGK SNQWVITWRD QLIGKLPQDI INTSYNYTDM YSTYQERNQN
360 370 380 390 400
KTSPAIRITD TRHRIPATNT SSSARYSAQS TQAGSQTAVS GTAFGKGVLG
410 420 430 440 450
SIYRPSTTIR KDERIVTDHK ELRTYTPGYS SWKHTETQQK TIPERKKTEV
460 470 480 490 500
TSSSTVSFSK QSTHAERSDK DNKADTKPKI SESLRTKSNF SKFPTYELNT
510 520 530 540 550
SSKPSVYEET ITETRTTIKE KRGGSKPTEE GTSLPKEKDK LEKQTKEEKR
560 570 580 590 600
KVDEKTFVEE RSVNFGRQTD AKMGIEQKKY VREEVISQKV AESDISNART
610 620 630 640 650
LKKESSKKDT DVSFESKSKE VIEIPITLER PAPDKVSQKK NEDISSQDFK
660 670 680 690 700
TSRGRETGDH VTKPAEIHKI RVSESDLRDE EKTSDRSHKM KTLATESIAE
710 720 730 740 750
NIAADILKSF TPSSSSEVST DTKVTSSSKQ EQPDDGKIRT EITVQSRVQE
760 770 780 790 800
NIDVSAEADR GSLSNQDVRK VLESAEGTPS KQEIENIVRH GLKGSGVAKN
810 820 830 840 850
MSVNVEIVEE TVDYTTDERT DFSTPFEVEE VEDTFPEREK RYGDDEQDIT
860 870 880 890 900
LTYEDLKKKK QRHESFTHVE EVTEEDDSPI EQKYFVSVPD DHPIINEKDD
910 920 930 940 950
DSVYGQIHIE EESTIKYSWQ DDFVQGTQSK RDEGVSSPEE TYRVVGEEAA
960 970 980 990 1000
AHILKEEHPK AGTSHVESVV IEKEIKIPQE FQASIKGLLS KETKDPKQQL
1010 1020 1030 1040 1050
KEALEQLGGS LPESVKEELS ALTKESQADS SNLEFDIKKV HQTEEGGLLT
1060 1070 1080 1090 1100
IVAEVNLSQT INADEFDIAQ LGEIIAGEKE KTTSHSLKRD KLERVAGGKI
1110 1120 1130 1140 1150
STETDVSARS DIYTPVANQE VYKSSTVRKT GSTGYHTTEK VIYDSSILET
1160 1170 1180 1190 1200
ANLGEDSHSP ESTDESKSVR HIRVGPTEVQ RFEQIVYEGP GSEMLGLSAT
1210 1220 1230 1240 1250
EDVVQTEGTS EMSHSVKHFK LGPKEIQTTE EVIYRGPITT TVEEIDSGNL
1260 1270 1280 1290 1300
SQQTFSSDIN RSTRHVTVGS RQVIEEVSFE GLGSDSLELN SSGHLSQSEG
1310 1320 1330 1340 1350
SVDVSRSVRQ FRLHPKEIHS EQVIFEGPIS GKVEVSDSRD FSQTESSVRH
1360 1370 1380 1390 1400
IQLGPKEFMT AEKVIYQGPI TEHIEISEVG DQTHSESSVK HFRLGQTGVR
1410 1420 1430 1440 1450
TTERIIYQGS LSETPELINK GHLSENEGSS DISTSFRHVR ITPVETQTEQ
1460 1470 1480 1490 1500
IIFTRPISET LEDHSQARES SESSSSMKHV KVGSSGTSFT FQMDVSNVGG
1510 1520 1530 1540 1550
VSMAESEEQA TVVISNKQDP SVNQSQFRVE SDHSGDSENK RSYIHSSFSQ
1560 1570 1580 1590 1600
DHVENVVEKS DFDKTVQLQR MVDQRSVISD DKKVALLYLD HEEEDDEEND

GQWF
Length:1,604
Mass (Da):182,188
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC30A09488C519041
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U28143 mRNA Translation: AAA80653.2

Protein sequence database of the Protein Information Resource

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PIRi
I50721

NCBI Reference Sequences

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RefSeqi
NP_990140.2, NM_204809.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Gga.4306

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
395599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395599

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28143 mRNA Translation: AAA80653.2
PIRiI50721
RefSeqiNP_990140.2, NM_204809.3
UniGeneiGga.4306

3D structure databases

ProteinModelPortaliQ90662
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395599
KEGGigga:395599

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23336

Phylogenomic databases

HOGENOMiHOG000154476
HOVERGENiHBG008974
KOiK10376
OrthoDBi104920at2759
PhylomeDBiQ90662

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
PANTHERiPTHR23239 PTHR23239, 2 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90662_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90662
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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