UniProtKB - Q90643 (IRF3_CHICK)
Protein
Interferon regulatory factor 3
Gene
IRF3
Organism
Gallus gallus (Chicken)
Status
Functioni
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 12 – 116 | IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST | 105 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- defense response to virus Source: UniProtKB-KW
- immune system process Source: GO_Central
- positive regulation of type I interferon production Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- toll-like receptor signaling pathway Source: AgBase
- TRIF-dependent toll-like receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Antiviral defense, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-GGA-1227882, TRAF mediated activation of IRF R-GGA-433819, Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK R-GGA-434136, Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon regulatory factor 3Short name: IRF-3 |
Gene namesi | Name:IRF3 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154555 | 1 – 491 | Interferon regulatory factor 3Add BLAST | 491 |
Proteomic databases
PaxDbi | Q90643 |
Expressioni
Tissue specificityi
Widely expressed with higher expression in lung, spleen and intestine.1 Publication
Inductioni
Up-regulated by poly I:C.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the IRF family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | ENOG502R2I9, Eukaryota |
InParanoidi | Q90643 |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q90643 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q90643-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALDSEGDA QKLRFGPWLL NAVSSGLYRG LCWIDPDRRI FRIPWKHNAR
60 70 80 90 100
KDVTSSDVEI FKAWAKASGR YEGNAEDPAK WKTNFRCALR STHMFMLLED
110 120 130 140 150
RSKCNDDPHK VYAVASGVPN DRGSGGPVAG ALQQQPQLLL NHHDLALENT
160 170 180 190 200
PTDSTEGVAA AALTQVDLDL LQSVLQHCNI SALGSQPTLW AHTGDALPED
210 220 230 240 250
ALLLPGQDGC LPGPQFQDWR QLEEPLLLGN QPLTGGGCGQ DGAGALPVSE
260 270 280 290 300
ECAIPAPSPA EELLFQSANP APPPPAGDIG GLPPLLDITI YYRGKMVYQE
310 320 330 340 350
QVDDSRCVLA YQPLDPAVAE QRLVLFPSPA SLPDPRQRRY TEDLLEVAGL
360 370 380 390 400
RLEQRAGQLL ATRLKKCKVF WALSQQLEGG EPPLNLLHRD QETTIFDFRV
410 420 430 440 450
FCTELRDFRD SRRERSPDFT IFLCFGQCFS STKPKESKLI LVKLVPQFCE
460 470 480 490
YWYEQVQRGG ASSLNSGNVS LQLSDSFNLF ELIEQYHMQT D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20338 mRNA Translation: AAA86995.1 |
PIRi | S56753 |
RefSeqi | NP_990703.1, NM_205372.1 |
Genome annotation databases
GeneIDi | 396330 |
KEGGi | gga:396330 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20338 mRNA Translation: AAA86995.1 |
PIRi | S56753 |
RefSeqi | NP_990703.1, NM_205372.1 |
3D structure databases
SMRi | Q90643 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000038233 |
Proteomic databases
PaxDbi | Q90643 |
Genome annotation databases
GeneIDi | 396330 |
KEGGi | gga:396330 |
Organism-specific databases
CTDi | 3665 |
Phylogenomic databases
eggNOGi | ENOG502R2I9, Eukaryota |
InParanoidi | Q90643 |
OrthoDBi | 648909at2759 |
PhylomeDBi | Q90643 |
Enzyme and pathway databases
Reactomei | R-GGA-1227882, TRAF mediated activation of IRF R-GGA-433819, Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK R-GGA-434136, Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 |
Miscellaneous databases
PROi | PR:Q90643 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IRF3_CHICK | |
Accessioni | Q90643Primary (citable) accession number: Q90643 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families