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Entry version 138 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Complement C3

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-2132273, Formation of membrane-bound convertase C3
R-GGA-2132281, Regulation of complement cascades
R-GGA-2132285, Complement Cascade
R-GGA-2132293, Formation of fluid-phase convertase C3
R-GGA-2173345, Anaphylatoxins initiate inflammatory responses

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement C3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500431864418 – 1652Sequence analysisAdd BLAST1635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi551 ↔ 809Interchain (between beta and alpha chains)UniRule annotation
Disulfide bondi619 ↔ 654UniRule annotation
Disulfide bondi686 ↔ 713UniRule annotation
Disulfide bondi687 ↔ 720UniRule annotation
Disulfide bondi700 ↔ 721UniRule annotation
Disulfide bondi865 ↔ 1501UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1002 ↔ 1005Isoglutamyl cysteine thioester (Cys-Gln)UniRule annotation
Disulfide bondi1093 ↔ 1149UniRule annotation
Disulfide bondi1348 ↔ 1478UniRule annotation
Disulfide bondi1378 ↔ 1447UniRule annotation
Disulfide bondi1495 ↔ 1500UniRule annotation
Disulfide bondi1506 ↔ 1579UniRule annotation
Disulfide bondi1526 ↔ 1650UniRule annotation
Disulfide bondi1626 ↔ 1635UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, Thioester bondUniRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini686 – 721Anaphylatoxin-likeInterPro annotationAdd BLAST36
Domaini1506 – 1650NTRInterPro annotationAdd BLAST145

Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
23785at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90633

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017, ANATO, 1 hit
cd03583, NTR_complement_C3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR041425, C3/4/5_MG1
IPR035711, Complement_C3-like
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035815, NTR_complement_C3
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF81, PTHR11412:SF81, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00004, ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01177, ANAPHYLATOXIN_1, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q90633-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLLLPLLL GVLLLHAVPT PAQMVTMVTP AVLRLDTDEK VVLEAPGLSA
60 70 80 90 100
PTEANILVQD FPQKRKVLFQ VRKQLNPAEG MMAIATVKVP VKLLPPVVGK
110 120 130 140 150
HFVSVVARVG QVTLEKVLLV SLQSGHIFLQ TDKPIYTPGS TVLSRLFALS
160 170 180 190 200
HFMQPLLKTV IVEVKTPDNV IIKQVPVSSP MRNGIFSINH NLPEVVSLGT
210 220 230 240 250
WTITAKFEDS QDQVFSTQFE VKEYVLPSFE VTLDPQEKFL YIDPAEDFRV
260 270 280 290 300
TITARYLYGK NLQGTAFVLF GVVVDDEKKT IPQSLQRVKV TDGDGQAVLP
310 320 330 340 350
MAMLRQPFAN LQELVGHSLY VTVTVLTESG SDMVEAQRSG IRIVTSPYTI
360 370 380 390 400
HFTHTPKYFK PGMPFDPTVY VTNPDNSPAA AGIPVKADNF QGLVSTQRDG
410 420 430 440 450
TAKLVLNMPA NKNSVPITVR TDQKDLPPER QASRQIVAEA YQSQGNSGNY
460 470 480 490 500
LHLAVGASQV QPGDNLPINF HLKSNRDDVR KSVSYFTYLI LSKGHIVHVG
510 520 530 540 550
RQPREGDQSL VTMSLPVTAN LIPSFRIVAY YHVKPGEIIA DSVWVDVKDT
560 570 580 590 600
CMGSLVVRGA SEADNRVHEP RTPMRLHIEG DHKAHVGLVA VDKAVYVLNK
610 620 630 640 650
NKLTQSKVWD TVENSDIGCT PGSGRNQVGV FADAGLSLTS NVNINTEQRS
660 670 680 690 700
EVQCAKPAKR KRRSVRLIKH KGTKMAEYSD KNLRKCCEDG IRKNLMGYSC
710 720 730 740 750
EKRATYVLDA KSCTEAFLSC CLYIKGIRDE ERELQYELAR SEVDDAFLSD
760 770 780 790 800
EDITSRSLFP ESWLWQVEEL TEPPNEQGIS MKTLPIYLKD SITTWEVLAV
810 820 830 840 850
SISENKGLCV ADPYEITVMK EFFIDLRLPY SAVRNEQVEV RAILYNYWTN
860 870 880 890 900
KIKVRVELMY NPALCSASTT KTRYQQIFQL EPQSSDAVPF VIVPLELGQH
910 920 930 940 950
DVEVKAAVWN SFVSDGVKKK LRVVPEGMRL EKTVKIVELD PKTLGNNGVQ
960 970 980 990 1000
EVKVKAANLS DIVPNTESET KVSIQGNPVS ILVEKATDGT KLKHLIVTPS
1010 1020 1030 1040 1050
GCGEQNMIGM TPTVIAVHYL DSTMQWETFG INRRTEAIEL IKKGYTQQLA
1060 1070 1080 1090 1100
YRKEDGSFAA FTTRPSSTWL TAYVAKVFAM AINMVDIKPE VVCGAIKWLI
1110 1120 1130 1140 1150
LEKQQPDGLF QEDAPVIHKE MVGGYHGAEP SVSLTAFVLS ALQESQKICK
1160 1170 1180 1190 1200
NYVKSLDGSI AKASDYLSRK YQSLTRPYTV ALTSYALALT GKLNSEKVLM
1210 1220 1230 1240 1250
KFSKDGTHWA ERNAHTYNIE GTSYALVALL QMEKAELTGP VVRWLAQQNY
1260 1270 1280 1290 1300
FGGGYGSTQA TILVFQALAQ YHVALPRHVE LNLDVSVLLP RRANAITYRI
1310 1320 1330 1340 1350
ENNNALVARS AETKLNEDFT VKAEGTGKGT MTVVTVYKAK VPEKENKCDN
1360 1370 1380 1390 1400
FDLRVSVEDV KAGREVEGVI RSVKITICTR FLDTVDATMS ILDISMLTAF
1410 1420 1430 1440 1450
SPDVQDLKSL SEGVERYISK FEIDHALSNR SNLIIYLDKV SHQVEECIAF
1460 1470 1480 1490 1500
RAHQHFQVGL IQPASVIVYS YYKIDDRCTR FYHPDKAGGQ LRKICHGEVC
1510 1520 1530 1540 1550
CAEENCFIRV KKDNPITVNE RIDLACKPGV DYVYKVKVVA TEETPSHDNY
1560 1570 1580 1590 1600
IMSILTVIKM GTDENPGGSN RTFVSHKQCR DALSLQKGQD YLVWGLASDL
1610 1620 1630 1640 1650
WVTGSRFSYL ISKDTWLEAW PLEESCQDAD LQPLCQDFTE FSDNLVLFGC

PT
Length:1,652
Mass (Da):184,086
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9020C49FE127BD1F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16848 mRNA Translation: AAA64694.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I50711

NCBI Reference Sequences

More...
RefSeqi
NP_990736.2, NM_205405.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16848 mRNA Translation: AAA64694.1
PIRiI50711
RefSeqiNP_990736.2, NM_205405.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI39.950

Genome annotation databases

GeneIDi396370
KEGGigga:396370

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
718

Phylogenomic databases

OrthoDBi23785at2759
PhylomeDBiQ90633

Enzyme and pathway databases

ReactomeiR-GGA-2132273, Formation of membrane-bound convertase C3
R-GGA-2132281, Regulation of complement cascades
R-GGA-2132285, Complement Cascade
R-GGA-2132293, Formation of fluid-phase convertase C3
R-GGA-2173345, Anaphylatoxins initiate inflammatory responses

Family and domain databases

CDDicd00017, ANATO, 1 hit
cd03583, NTR_complement_C3, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR041425, C3/4/5_MG1
IPR035711, Complement_C3-like
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035815, NTR_complement_C3
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold
PANTHERiPTHR11412:SF81, PTHR11412:SF81, 1 hit
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit
PRINTSiPR00004, ANAPHYLATOXN
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit
SUPFAMiSSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01177, ANAPHYLATOXIN_1, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90633_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90633
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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