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Protein

Kinectin

Gene

KTN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility.

Miscellaneous

A cytoplasmic form lacking the first 232 amino acids has been characterized.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinectin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KTN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 1364LumenalSequence analysisAdd BLAST1335

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843361 – 1364KinectinAdd BLAST1364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi638N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi775N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi976N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1061N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1094N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Both the membrane and cytoplasmic forms seem to be myristoylated.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90631

PRoteomics IDEntifications database

More...
PRIDEi
Q90631

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000019799

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q90631

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90631

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili315 – 1085Sequence analysisAdd BLAST771
Coiled coili1116 – 1306Sequence analysisAdd BLAST191

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIAW Eukaryota
ENOG410YAE3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113267

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007851

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90631

KEGG Orthology (KO)

More...
KOi
K17975

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90631

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024854 Kinectin

The PANTHER Classification System

More...
PANTHERi
PTHR18864 PTHR18864, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.
Isoform 1 (identifier: Q90631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFYESTYFI ILIPSVVITV IFLFFWLFMK ETLYDEVLAK QKRDLKFPPT
60 70 80 90 100
KSDKKKTEKK KNKKKEAQNG NIHESDSEST PRDFKLSDAL GTDEEQVAPV
110 120 130 140 150
PLSATEASAG IRERKKKEKK QKAAQDDHVT KESEGSKSSG KKVEPVPVTK
160 170 180 190 200
QPTPPSEPAA AKKKPGQKKQ KNDDQDTKTD SVASPAKKQE PVLLHQEVKQ
210 220 230 240 250
ENVSGKKKVS AKKQKVLVDE PLIQPTTYIP LVDNSDAGAL EKREVVEVAK
260 270 280 290 300
QNMNEGIQKS GGKKMKNETD KENAEVKFKD FVMAMKNMIF TEDEARCVVE
310 320 330 340 350
VLKEKSGAIH DVLQKASKAE SAAAIHQLQD KEKLLAAVKE EAAVAKEQCK
360 370 380 390 400
QLTQELVAEK ERNGLLTAKM RERINALEKE HGTFQSKIHV SYQESQQMKI
410 420 430 440 450
KFQQRCEQME AEISHLKQEN TILRDAVSTS TNQMESKQAA ELNKLRQDCA
460 470 480 490 500
RLVNELGEKN SKLQQEELQK KNAEQAVAQL KVQQQEAERR WEEIQVYLRK
510 520 530 540 550
RTAEHEAAQQ DVQNKLVAKD NEIQSLHSKL TDMVVSKQQL EQRMLQLIES
560 570 580 590 600
EQKRASKEDS MQLRVQELVE QNDALNAQLQ KLHSQMAAQT SASVLAEELH
610 620 630 640 650
KVIAEKDKQL KQMEDSLGNE HANLTSKEEE LKVLQNMNLS LKSEIQKLQA
660 670 680 690 700
LTNEQAAAAH ELERMQKSIH IKDDKIRTLE EQLREELAQT VNTKEEFKIL
710 720 730 740 750
KDQNKTLQAE VQKLQALLSE PVQPTFEANK DLLEEMERGM RERDDKIKTV
760 770 780 790 800
EELLEAGLIQ MANKEEELKV LRTENSSLRK ELQSLQIQLS EQVSFQSLVD
810 820 830 840 850
ELQKVIHEKD GKIKSVEELL QAEILKVANK EKTVQALTQK IEALKEEVGN
860 870 880 890 900
SQLEMEKQVS ITSQVKELQT LLKGKENQVK TMEALLEEKE KEIVQKGERL
910 920 930 940 950
KGQQDTVAQL TSKVQELEQQ NLQQLQQVPA ASQVQDLESR LRGEEEQISK
960 970 980 990 1000
LKAVLEEKER EIASQVKQLQ TMQSENESFK VQIQELKQEN CKQASLAVQS
1010 1020 1030 1040 1050
EELLQVVAGK EKEIASLQNE LACQRNAFEQ QRKKNNDLRE KNWKAMEALA
1060 1070 1080 1090 1100
STEKLLQDKV NKTAKEKQQH VEAAEVETRE LLQKLFPNVS LPANVSHSEW
1110 1120 1130 1140 1150
ICGFEKMAKE YLRGASGSED IKVMEQKLKE AEELHILLQL ECEKYKSVLA
1160 1170 1180 1190 1200
ETEGILQRLQ RSVEEEESKW KIKVEESQKE LKQMRSSVAS LEHEVERLKE
1210 1220 1230 1240 1250
EIKEVETLKK EREHLESELE KAEIERSTYV SEVRELKDLL TELQKKLDDS
1260 1270 1280 1290 1300
YSEAVRQNEE LNLLKMKLSE TLSKLKVDQN ERQKVAGDLP KAQESLASLE
1310 1320 1330 1340 1350
REIGKVVGDA NVIENSDVRT ESELTDKRLN VAVNLNQDVG HLKKLLVSVS
1360
QMLSKGREHY QLVE
Length:1,364
Mass (Da):155,976
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i176BB11A19A80F00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U15617 mRNA Translation: AAA85818.1

NCBI Reference Sequences

More...
RefSeqi
NP_990707.1, NM_205376.1 [Q90631-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.3640

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396335

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15617 mRNA Translation: AAA85818.1
RefSeqiNP_990707.1, NM_205376.1 [Q90631-1]
UniGeneiGga.3640

3D structure databases

ProteinModelPortaliQ90631
SMRiQ90631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019799

Proteomic databases

PaxDbiQ90631
PRIDEiQ90631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396335
KEGGigga:396335

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3895

Phylogenomic databases

eggNOGiENOG410IIAW Eukaryota
ENOG410YAE3 LUCA
HOGENOMiHOG000113267
HOVERGENiHBG007851
InParanoidiQ90631
KOiK17975
PhylomeDBiQ90631

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q90631

Family and domain databases

InterProiView protein in InterPro
IPR024854 Kinectin
PANTHERiPTHR18864 PTHR18864, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKTN1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90631
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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