UniProtKB - Q90600 (RB_CHICK)
Protein
Retinoblastoma-associated protein
Gene
RB1
Organism
Gallus gallus (Chicken)
Status
Functioni
Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting chromatin-modifying enzymes to promoters (By similarity).By similarity
GO - Molecular functioni
- RNA polymerase II activating transcription factor binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell differentiation Source: GO_Central
- cell morphogenesis involved in neuron differentiation Source: GO_Central
- chromatin organization Source: UniProtKB-KW
- negative regulation of cell growth Source: UniProtKB
- negative regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- neuron projection development Source: GO_Central
- regulation of transcription by RNA polymerase II Source: InterPro
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Repressor |
Biological process | Cell cycle, Host-virus interaction, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoblastoma-associated proteinAlternative name(s): p104 pRb Short name: Rb |
Gene namesi | Name:RB1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB
- Rb-E2F complex Source: UniProtKB
Other locations
- chromatin Source: GO_Central
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331619 | 1 – 921 | Retinoblastoma-associated proteinAdd BLAST | 921 |
Post-translational modificationi
Phosphorylated in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. Phosphorylation of domain C promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q90600 |
Interactioni
Subunit structurei
Interacts with and sequesters the E2F1 transcription factor.
Interacts with SUV39H1, KMT5B and KMT5C (By similarity).
By similarity(Microbial infection) Interacts with, and is inhibited by fowl adenovirus 1 protein GAM-1.
1 PublicationGO - Molecular functioni
- RNA polymerase II activating transcription factor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000027407 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 853 – 869 | Bipartite nuclear localization signalBy similarityAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the retinoblastoma protein (RB) family.Curated
Phylogenomic databases
eggNOGi | KOG1010, Eukaryota |
InParanoidi | Q90600 |
OrthoDBi | 113612at2759 |
PhylomeDBi | Q90600 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR002720, RB_A IPR002719, RB_B IPR015030, RB_C IPR028309, RB_fam IPR024599, RB_N |
PANTHERi | PTHR13742, PTHR13742, 1 hit |
Pfami | View protein in Pfam PF11934, DUF3452, 1 hit PF01858, RB_A, 1 hit PF01857, RB_B, 1 hit PF08934, Rb_C, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01367, DUF3452, 1 hit SM01368, RB_A, 1 hit SM01369, Rb_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
i Sequence
Sequence statusi: Complete.
Q90600-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPKPLRRAG AARSQRTSPE GGAGTASPPG GTRLEVGEAE FVALCDALKA
60 70 80 90 100
PDSVREKAWM TYQSLAAADG ASAYNKKKKE TWGVCIFIVA IDLDEMTFTF
110 120 130 140 150
TELLKSLSIS VCTFFQFLKE VDVNMDTVST KVDSTVSRLK KKYDVLLALY
160 170 180 190 200
HKFERTCGLI YLEQPSSEIS AELSSVLVLK NYWITFLLAK GKVLQMEDDL
210 220 230 240 250
VISFQLLLCV LDYFIKLSPP AMLKEPYKSA VTALTVNGST RTPRRGQNRN
260 270 280 290 300
ARASKQIDTD TKVIEILCKE HDCNLDEVKN VYFTSFIPFL NSLGVVASNG
310 320 330 340 350
LPEVDVLSKQ YDELYLKNKD IDARLFLDHD ETLQPDVIAC SQLERTPRKN
360 370 380 390 400
NPDEEVNHVL PQTPVRAAMN TIQQLMMILN SATDKPSDTL IAYFNNCTVN
410 420 430 440 450
PEDSILKRVE SLGHIFKKKF AEAVGQGCAE IGSQRYQLGV RLYYRVMESM
460 470 480 490 500
LKSEEERLSV HNFSKLLNDN IFHTSLLACA LEIVMATYGR TASQSDGTSA
510 520 530 540 550
ETDLSFPWIL NVFDLKAFDF YKVIESFIKV EPSLTRDMIK HLERCEHRIM
560 570 580 590 600
ESLAWQSDSP LFDLIKQSKE REGQTDQPEP TSTLNLPLQH NHTAADLYLS
610 620 630 640 650
PVRSPKKKAS GHPQSGTSNP DAQPSATSQT QKPQKSTSLS LFYKKVFRLA
660 670 680 690 700
YLRLHTLFFR LLSEHPDLEP LIWTLFQHTL QNESELMRDR HLDQIMMCSM
710 720 730 740 750
YGICKVKNVD LRFKTIVSAY KELPNTNQET FKRVLIREEQ YDSIIVFYNL
760 770 780 790 800
VFMQKLKTNI LQYASNRPPT LSPIPHIPRS PYQFSNSPRR VPAGNNIYIS
810 820 830 840 850
PLKSPYKFSD GFHSPTKMTP RSRILVSIGE TFGTSEKFQK INQMVCNSES
860 870 880 890 900
HVKRSAEPSD APKPLKRLRF DIEGQDEADG GKHLPQESKF QQKLAEMTST
910 920
RTRMQKQKLN DGNDTSANEE K
Sequence cautioni
The sequence AAA19644 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | Q → E in AAA19644 (PubMed:8193168).Curated | 1 | |
Sequence conflicti | 163 | E → S in AAA19644 (PubMed:8193168).Curated | 1 | |
Sequence conflicti | 411 | S → C in AAA19644 (PubMed:8193168).Curated | 1 | |
Sequence conflicti | 619 | N → G in AAA19644 (PubMed:8193168).Curated | 1 | |
Sequence conflicti | 791 – 792 | VP → A in AAA19644 (PubMed:8193168).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X72218 mRNA Translation: CAA51019.1 U00113 mRNA Translation: AAA19644.1 Frameshift. X72217 Genomic DNA Translation: CAA51018.1 |
PIRi | S45298 |
RefSeqi | NP_989750.1, NM_204419.1 |
Genome annotation databases
GeneIDi | 386582 |
KEGGi | gga:386582 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X72218 mRNA Translation: CAA51019.1 U00113 mRNA Translation: AAA19644.1 Frameshift. X72217 Genomic DNA Translation: CAA51018.1 |
PIRi | S45298 |
RefSeqi | NP_989750.1, NM_204419.1 |
3D structure databases
SMRi | Q90600 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000027407 |
Proteomic databases
PaxDbi | Q90600 |
Genome annotation databases
GeneIDi | 386582 |
KEGGi | gga:386582 |
Organism-specific databases
CTDi | 5925 |
Phylogenomic databases
eggNOGi | KOG1010, Eukaryota |
InParanoidi | Q90600 |
OrthoDBi | 113612at2759 |
PhylomeDBi | Q90600 |
Miscellaneous databases
PROi | PR:Q90600 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR002720, RB_A IPR002719, RB_B IPR015030, RB_C IPR028309, RB_fam IPR024599, RB_N |
PANTHERi | PTHR13742, PTHR13742, 1 hit |
Pfami | View protein in Pfam PF11934, DUF3452, 1 hit PF01858, RB_A, 1 hit PF01857, RB_B, 1 hit PF08934, Rb_C, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01367, DUF3452, 1 hit SM01368, RB_A, 1 hit SM01369, Rb_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RB_CHICK | |
Accessioni | Q90600Primary (citable) accession number: Q90600 Secondary accession number(s): Q788Q6, Q90599, Q91016 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families