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Entry version 107 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Interferon-induced GTP-binding protein Mx

Gene

MX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi121 – 128GTPSequence analysis8
Nucleotide bindingi222 – 226GTPSequence analysis5
Nucleotide bindingi291 – 294GTPSequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx
Alternative name(s):
Interferon-inducible Mx protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066031 – 705Interferon-induced GTP-binding protein MxAdd BLAST705

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90597

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interferons.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000025952

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90597

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 384Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini616 – 705GEDPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni121 – 128G1 motifPROSITE-ProRule annotation8
Regioni146 – 148G2 motifPROSITE-ProRule annotation3
Regioni222 – 225G3 motifPROSITE-ProRule annotation4
Regioni291 – 294G4 motifPROSITE-ProRule annotation4
Regioni323 – 326G5 motifPROSITE-ProRule annotation4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0446, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90597

Database of Orthologous Groups

More...
OrthoDBi
494748at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90597

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08771, DLP_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR11566, PTHR11566, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00195, DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNPWSNFSS AFGCPIQIPK QNSNVPPSLP VPVGVFGVPL RSGCSNQMAF
60 70 80 90 100
CAPELTDRKP EHEQKVSKRL NDREEDKDEA AACSLDNQYD RKIQPCIDLV
110 120 130 140 150
DSLRKLDIGN DLMLPAIAVI GDRNSGKSSV LEALSGVALP RDKGVITRCP
160 170 180 190 200
LELKLKKMTA PQEWKGVIYY RNTEIQLQNA SEVKKAIRKA QDIVAGTNGS
210 220 230 240 250
ISGELISLEI WSPDVPDLTL IDLPGIAREA VGNQPQDNGQ QIKTLLKKYI
260 270 280 290 300
GCKETIIVVV VPCNVDIATT EALKMAQEVD PTGERTLGVL TKPDLVNEGT
310 320 330 340 350
EETVLKIIQN EVIPLRKGYM IVKCYGQMDF CNELSFTSAI QQEREFFETH
360 370 380 390 400
KHFSTLLDEN KATIPHLANK LTDELVGRII KTLPAIEKQV HDALQQAKKE
410 420 430 440 450
LQKYTQSTHP TVSDKTIFLV GLIKAFNEDI SQTMHGKESW FGNEIRLFPK
460 470 480 490 500
IRREFRTWGV KLLESSAKVE EIVCSKLPKY EDQYRGREFP DFISYWTFED
510 520 530 540 550
IIKEQITKLE EPAVAMLNKV IYMVEEKFLQ LANKRFANFQ NLNNAAQARI
560 570 580 590 600
GCISDRQATT AKNCILTQFK MERIIYCQDN IYADDLKAAR AEGISKDTKI
610 620 630 640 650
KDLAFGCASR QCPSFALEMV SHVKAYFTGA SKRLSNQIPL IILSTVLHDF
660 670 680 690 700
GNYLQTSMLH LLQGKEEINY LLQEDHEAAN QQKLLTSRIS HLNKAYQYLV

DFKSL
Length:705
Mass (Da):79,493
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88378C25B737482B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti5W → R in strain: 16, 17, 25, 7, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti8F → S in strain: Black-bone. 1
Natural varianti21Q → R in strain: 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti41R → P in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti42S → L in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti72D → N in strain: WL-N. 1
Natural varianti84S → N in strain: WL-N. 1
Natural varianti94Q → R in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti143K → E in strain: WL-F. 1
Natural varianti152E → K in strain: WL-F. 1
Natural varianti158M → V in strain: WL-N. 1
Natural varianti202S → T in strain: 16, 17. 1
Natural varianti308I → V in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti317K → E in strain: WL-F. 1
Natural varianti339A → T in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti352H → R in strain: WL-N. 1
Natural varianti377G → E in strain: Black-bone. 1
Natural varianti505Q → R in strain: Black Minorca and Fayoumi GSP. 1
Natural varianti530Q → R in strain: Black-bone. 1
Natural varianti548A → V in strain: 25, WL-F and WL-N. 1
Natural varianti583A → T in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti631S → N in strain: 25, Black-bone, WL-F and WL-N. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z23168 mRNA Translation: CAA80686.1
AB088533 mRNA Translation: BAC06346.1
AB088534 mRNA Translation: BAC06347.1
AB088535 mRNA Translation: BAC06348.1
AB088536 mRNA Translation: BAC06349.1
AB244818 mRNA Translation: BAF30836.1
DQ788613 Genomic DNA Translation: ABH07788.1
DQ788614 Genomic DNA Translation: ABH07789.1
DQ788615 Genomic DNA Translation: ABH07790.1
DQ788616 Genomic DNA Translation: ABH07791.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S34155

NCBI Reference Sequences

More...
RefSeqi
NP_989940.1, NM_204609.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395313

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23168 mRNA Translation: CAA80686.1
AB088533 mRNA Translation: BAC06346.1
AB088534 mRNA Translation: BAC06347.1
AB088535 mRNA Translation: BAC06348.1
AB088536 mRNA Translation: BAC06349.1
AB244818 mRNA Translation: BAF30836.1
DQ788613 Genomic DNA Translation: ABH07788.1
DQ788614 Genomic DNA Translation: ABH07789.1
DQ788615 Genomic DNA Translation: ABH07790.1
DQ788616 Genomic DNA Translation: ABH07791.1
PIRiS34155
RefSeqiNP_989940.1, NM_204609.1

3D structure databases

SMRiQ90597
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025952

Proteomic databases

PaxDbiQ90597

Genome annotation databases

GeneIDi395313
KEGGigga:395313

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4599

Phylogenomic databases

eggNOGiKOG0446, Eukaryota
InParanoidiQ90597
OrthoDBi494748at2759
PhylomeDBiQ90597

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q90597

Family and domain databases

CDDicd08771, DLP_1, 1 hit
InterProiView protein in InterPro
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
PANTHERiPTHR11566, PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PRINTSiPR00195, DYNAMIN
SMARTiView protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMX_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90597
Secondary accession number(s): Q0KKN7
, Q0PMS3, Q0PMS4, Q0PMS5, Q0PMS6, Q8JFB6, Q8JIF6, Q8JIF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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