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Protein

Transcription factor MafK

Gene

MAFK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Gene namesi
Name:MAFK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765051 – 156Transcription factor MafKAdd BLAST156

Proteomic databases

PaxDbiQ90596
PRIDEiQ90596

Expressioni

Gene expression databases

BgeeiENSGALG00000004189

Interactioni

Subunit structurei

Homodimer or heterodimer.

Protein-protein interaction databases

IntActiQ90596, 1 interactor
MINTiQ90596
STRINGi9031.ENSGALP00000006645

Structurei

3D structure databases

ProteinModelPortaliQ90596
SMRiQ90596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISHX Eukaryota
ENOG4111MYK LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000045475
HOVERGENiHBG001725
InParanoidiQ90596
KOiK09037
OMAiLQCFART
OrthoDBiEOG091G0H46
PhylomeDBiQ90596
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR028574 MafK
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF26 PTHR10129:SF26, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q90596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKEESGEN APVLSDDELV SMSVRELNQH LRGLTKEEVI
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
KLELDALRSK YEALQTFART VARGPITPTK VATTSVITIV KSAEISSSSV

PFSAAS
Length:156
Mass (Da):17,538
Last modified:November 1, 1997 - v1
Checksum:i4F45BCE40DA41C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16187 mRNA Translation: BAA03728.1
PIRiA56253
RefSeqiNP_990087.1, NM_204756.1
XP_015149619.1, XM_015294133.1
XP_015149620.1, XM_015294134.1
UniGeneiGga.45251

Genome annotation databases

EnsembliENSGALT00000006656; ENSGALP00000006645; ENSGALG00000004189
ENSGALT00000054791; ENSGALP00000046925; ENSGALG00000004189
GeneIDi395518
KEGGigga:395518

Similar proteinsi

Entry informationi

Entry nameiMAFK_CHICK
AccessioniPrimary (citable) accession number: Q90596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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