UniProtKB - Q90459 (CCND1_DANRE)
G1/S-specific cyclin-D1
ccnd1
Functioni
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
By similarityGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- camera-type eye morphogenesis Source: ZFIN
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- G1/S transition of mitotic cell cycle Source: UniProtKB
- mitotic cell cycle phase transition Source: GO_Central
- mitotic G1 DNA damage checkpoint signaling Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuron cellular homeostasis Source: ZFIN
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of neural retina development Source: ZFIN
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DRE-3214858, RMTs methylate histone arginines R-DRE-69231, Cyclin D associated events in G1 R-DRE-75815, Ubiquitin-dependent degradation of Cyclin D R-DRE-8849470, PTK6 Regulates Cell Cycle R-DRE-8878166, Transcriptional regulation by RUNX2 R-DRE-8934593, Regulation of RUNX1 Expression and Activity R-DRE-8951936, RUNX3 regulates p14-ARF |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-D1 |
Gene namesi | Name:ccnd1 Synonyms:cycd1 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-980526-176, ccnd1 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080435 | 1 – 291 | G1/S-specific cyclin-D1Add BLAST | 291 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 282 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q90459 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000101637, Expressed in blastula and 64 other tissues |
ExpressionAtlasi | Q90459, baseline and differential |
Interactioni
Subunit structurei
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000051867 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | CLU_052190_0_0_1 |
InParanoidi | Q90459 |
OMAi | SCYRTTH |
OrthoDBi | 1234739at2759 |
PhylomeDBi | Q90459 |
TreeFami | TF101004 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEHQLFCCEV DTIRRAYQDS NLLNDRVLQT MLKAEENYLP SPNYFKCVQK
60 70 80 90 100
EIVPKMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS VEPTKKTRLQ
110 120 130 140 150
LLGATCMFLA SKMKETVPLT AEKLCIYTDN SVRPGELLQM ELLALNKLKW
160 170 180 190 200
DLASVTPHDF IEHFLAKLPI HQSSKQILRK HAQTFVALCA TDVNFIASPP
210 220 230 240 250
SMIAAGSVAA AVQGLYLKST DSCLSSQNLT NFLSQVIRSD PDCLRSCQEQ
260 270 280 290
IESLLESSLR QAQQHISTET KRVEEDVDLS CTPTDVRDIN I
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IEY8 | A0A0R4IEY8_DANRE | G1/S-specific cyclin-D1 | ccnd1 | 210 | Annotation score: | ||
A0A0R4IAQ3 | A0A0R4IAQ3_DANRE | G1/S-specific cyclin-D1 | ccnd1 | 76 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87581 mRNA Translation: CAA60885.1 BC075743 mRNA Translation: AAH75743.1 |
PIRi | S62730 |
RefSeqi | NP_571100.1, NM_131025.4 |
Genome annotation databases
Ensembli | ENSDART00000163748; ENSDARP00000140550; ENSDARG00000101637 ENSDART00000165320; ENSDARP00000134435; ENSDARG00000101637 |
GeneIDi | 30222 |
KEGGi | dre:30222 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87581 mRNA Translation: CAA60885.1 BC075743 mRNA Translation: AAH75743.1 |
PIRi | S62730 |
RefSeqi | NP_571100.1, NM_131025.4 |
3D structure databases
SMRi | Q90459 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000051867 |
Proteomic databases
PaxDbi | Q90459 |
Genome annotation databases
Ensembli | ENSDART00000163748; ENSDARP00000140550; ENSDARG00000101637 ENSDART00000165320; ENSDARP00000134435; ENSDARG00000101637 |
GeneIDi | 30222 |
KEGGi | dre:30222 |
Organism-specific databases
CTDi | 595 |
ZFINi | ZDB-GENE-980526-176, ccnd1 |
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | CLU_052190_0_0_1 |
InParanoidi | Q90459 |
OMAi | SCYRTTH |
OrthoDBi | 1234739at2759 |
PhylomeDBi | Q90459 |
TreeFami | TF101004 |
Enzyme and pathway databases
Reactomei | R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DRE-3214858, RMTs methylate histone arginines R-DRE-69231, Cyclin D associated events in G1 R-DRE-75815, Ubiquitin-dependent degradation of Cyclin D R-DRE-8849470, PTK6 Regulates Cell Cycle R-DRE-8878166, Transcriptional regulation by RUNX2 R-DRE-8934593, Regulation of RUNX1 Expression and Activity R-DRE-8951936, RUNX3 regulates p14-ARF |
Miscellaneous databases
PROi | PR:Q90459 |
Gene expression databases
Bgeei | ENSDARG00000101637, Expressed in blastula and 64 other tissues |
ExpressionAtlasi | Q90459, baseline and differential |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCND1_DANRE | |
Accessioni | Q90459Primary (citable) accession number: Q90459 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families