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Entry version 93 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

L1-like cell adhesion molecule antigen E587

Gene
N/A
Organism
Carassius auratus (Goldfish)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
L1-like cell adhesion molecule antigen E587Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCarassius auratus (Goldfish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7957 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1090 – 1111HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 99Ig-likeInterPro annotationAdd BLAST85
Domaini103 – 194Ig-likeInterPro annotationAdd BLAST92
Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89
Domaini302 – 389Ig-likeInterPro annotationAdd BLAST88
Domaini395 – 476Ig-likeInterPro annotationAdd BLAST82
Domaini485 – 570Ig-likeInterPro annotationAdd BLAST86
Domaini583 – 679Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini684 – 776Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini781 – 891Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini892 – 991Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini992 – 1089Fibronectin type-IIIInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni663 – 692DisorderedSequence analysisAdd BLAST30
Regioni1191 – 1232DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi666 – 692PolarSequence analysisAdd BLAST27

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90284-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPPDYTYSN LKQAPTITVQ PVSHTAFSLD DVILACEASG DPAPSFRWVK
60 70 80 90 100
DGKEFKRELL SSGTLTAEDK EELHPIQGSY RCYVMSLGTA VSDLAQLITE
110 120 130 140 150
PIPTLAKEKR QKTRSFEEGD SAVLYCNPPK SSVTPKIHWM DMHWRHIPLN
160 170 180 190 200
ERVTTSLDGN LYFANLLVND SREDYTCNAH IINASVILPK ERISISVTPS
210 220 230 240 250
NSVLKNRRPQ LQKPAGSHSS YLVLRGQTLT LECIPEGLPT PEVQWERMDS
260 270 280 290 300
PLSPARVRWL KYKRWLQIES VSEADDGEYT CTAQNSQGSV KHHYAVTVEA
310 320 330 340 350
APYWTRRPEN HLYAPGETVR LDCQAEGIPT PNITWSMNGA PIAGTDPDPR
360 370 380 390 400
RHVSSGTLIL TDVQISDTAV YHVEATNKHG NILINTHVHV VELPPQILTE
410 420 430 440 450
DDLKYEATEG QTVLLQCRTF GSPQPKVDWQ ITNSGPALAN AKMSQTSDGN
460 470 480 490 500
LQISDVSEED SSMYTCSVST SNMSISAELV VLNRTKIVDP PQDLRVLRGD
510 520 530 540 550
DAVLQCRYTV DHMLKQPTIQ WKKDKHKITS SANDDKYTES PDGSLKITDV
560 570 580 590 600
QMEDSGIYSC EISTKLDSVS ATGSIVVLDK PGSPHSLELS EKKERSVTLS
610 620 630 640 650
WMPGAENNSP ISEYVIERKE KQNPGKGHWE EYRRVPQDIT HLEIHLQPYS
660 670 680 690 700
TYHFRVRGVN GIGMSEPSPP SESYSTPAAK PDMNPENVTS VSTDSNSLVI
710 720 730 740 750
TWQELEQRQF NGPGFKYKIY WRQEGDSHWM ESSASNPPFI VEGPGTFIPF
760 770 780 790 800
QIKVQAVNEL GAGPEPDAEI GYSGEDLPLE APSSVAVSEL NKTTVLVKWS
810 820 830 840 850
PVSTKSVRGH LLGYKIHVRK KGPRAHSQRG LPMQEPAAER NRVIVANGNK
860 870 880 890 900
EEMVLSDLHF HSNYTLTVAP FNSKGEGPHS KRRITLATPE GAPGPLSFLT
910 920 930 940 950
FESPSETEIT LRWGAPDKPN GVLTGYLLQY YEPVPGSSST HQMKSLNLPL
960 970 980 990 1000
DTEYTLKDLN PQIQYHFSLR ALTAAGHGEP VEMEGATMLD GEPPSVINIT
1010 1020 1030 1040 1050
AGQTSVNISW VPGERPRSFA FSFRYLKKSA DGKWKESEKV NSSQAFYQLH
1060 1070 1080 1090 1100
GLTPGFQYKL EILPGNFTRE FETAGPELHE LPSSFVTQGW FIGLISALVL
1110 1120 1130 1140 1150
LLLVLLILCY IKKSKGGKYS VKDKEEDQVN GARTMKDGQF GQYKSLESDN
1160 1170 1180 1190 1200
EKCSTSQQSV CESKRSSNDS LADYGDSVDI QFNEDGSFIG QYSGRRDPNG
1210 1220 1230
HGSSGATCPV NPNMPPPSIS FPTSVTGFLG PN
Length:1,232
Mass (Da):136,483
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43086C06862C3B65
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U55211 mRNA Translation: AAA99159.1

Protein sequence database of the Protein Information Resource

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PIRi
T43027

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55211 mRNA Translation: AAA99159.1
PIRiT43027

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90284_CARAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90284
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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