UniProtKB - Q90275 (CADH2_DANRE)
Cadherin-2
cdh2
Functioni
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity).
Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (PubMed:12091300).
Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain (PubMed:12091300).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 157 | Calcium 1By similarity | 1 | |
Metal bindingi | 157 | Calcium 2By similarity | 1 | |
Metal bindingi | 213 | Calcium 1By similarity | 1 | |
Metal bindingi | 215 | Calcium 1By similarity | 1 | |
Metal bindingi | 215 | Calcium 2By similarity | 1 | |
Metal bindingi | 246 | Calcium 2By similarity | 1 | |
Metal bindingi | 247 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 248 | Calcium 3By similarity | 1 | |
Metal bindingi | 249 | Calcium 1By similarity | 1 | |
Metal bindingi | 249 | Calcium 2By similarity | 1 | |
Metal bindingi | 250 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 280 | Calcium 3By similarity | 1 | |
Metal bindingi | 282 | Calcium 2By similarity | 1 | |
Metal bindingi | 288 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 340 | Calcium 3By similarity | 1 |
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: UniProtKB
GO - Biological processi
- adherens junction organization Source: ZFIN
- auditory receptor cell stereocilium organization Source: ZFIN
- axial mesoderm structural organization Source: ZFIN
- axonal fasciculation Source: ZFIN
- axon guidance Source: ZFIN
- blood vessel morphogenesis Source: GO_Central
- brain development Source: ZFIN
- cardioblast differentiation Source: ZFIN
- cartilage condensation Source: ZFIN
- cell-cell adhesion Source: UniProtKB
- cell-cell adhesion mediated by cadherin Source: UniProtKB
- cell-cell adhesion via plasma-membrane adhesion molecules Source: ZFIN
- cell migration in hindbrain Source: ZFIN
- cell migration involved in somitogenic axis elongation Source: ZFIN
- cell morphogenesis Source: ZFIN
- cilium assembly Source: ZFIN
- commissural neuron axon guidance Source: ZFIN
- dorsal convergence Source: ZFIN
- dorsal fin morphogenesis Source: ZFIN
- ectoderm development Source: ZFIN
- embryonic eye morphogenesis Source: ZFIN
- embryonic pectoral fin morphogenesis Source: ZFIN
- embryonic retina morphogenesis in camera-type eye Source: ZFIN
- establishment of epithelial cell apical/basal polarity Source: ZFIN
- generation of neurons Source: ZFIN
- glial cell differentiation Source: UniProtKB
- hindbrain development Source: ZFIN
- hindbrain structural organization Source: ZFIN
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
- mesoderm morphogenesis Source: ZFIN
- midbrain development Source: ZFIN
- motor neuron axon guidance Source: ZFIN
- motor neuron migration Source: ZFIN
- negative regulation of neural precursor cell proliferation Source: ZFIN
- neural crest cell migration Source: ZFIN
- neural tube development Source: ZFIN
- neuronal stem cell population maintenance Source: UniProtKB
- neuron cell-cell adhesion Source: ZFIN
- neuron migration Source: ZFIN
- odontogenesis Source: ZFIN
- peripheral nervous system development Source: ZFIN
- pigment cell development Source: ZFIN
- post-anal tail morphogenesis Source: ZFIN
- regulation of axonogenesis Source: GO_Central
- regulation of eye photoreceptor cell development Source: ZFIN
- regulation of signal transduction Source: InterPro
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- retina development in camera-type eye Source: ZFIN
- semicircular canal morphogenesis Source: ZFIN
- sensory epithelium regeneration Source: ZFIN
- somitogenesis Source: ZFIN
- spinal cord patterning Source: ZFIN
- synapse assembly Source: ZFIN
- tissue regeneration Source: ZFIN
- ventricular system development Source: ZFIN
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Differentiation, Neurogenesis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-418990, Adherens junctions interactions R-DRE-525793, Myogenesis R-DRE-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-2Alternative name(s): Neural cadherin Short name: N-cadherin2 Publications Parachute1 Publication ZNCAD |
Gene namesi | Name:cdh2 Synonyms:pac1 Publication |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-990415-171, cdh2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- catenin complex Source: ZFIN
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic specialization membrane Source: GO_Central
- integral component of presynaptic active zone membrane Source: GO_Central
- plasma membrane Source: ZFIN
- presynaptic membrane Source: ZFIN
Other locations
- apical part of cell Source: GO_Central
- cytoplasm Source: GO_Central
- intercalated disc Source: UniProtKB
- lamellipodium Source: GO_Central
- neuron projection Source: GO_Central
- perinuclear region of cytoplasm Source: ZFIN
- postsynaptic density Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 147 – 711 | ExtracellularSequence analysisAdd BLAST | 565 | |
Transmembranei | 712 – 732 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 733 – 893 | CytoplasmicSequence analysisAdd BLAST | 161 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 501 – 893 | Missing in pac(fr7); causes abnormal embryonic brain and tail morphogenesis. 1 PublicationAdd BLAST | 393 | |
Mutagenesisi | 514 – 893 | Missing in pac(tm101B); causes abnormal embryonic brain and tail morphogenesis. 1 PublicationAdd BLAST | 380 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000003739 | 25 – 146 | Sequence analysisAdd BLAST | 122 | |
ChainiPRO_0000003740 | 147 – 893 | Cadherin-2Add BLAST | 747 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 312 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 442 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 559 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 609 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 638 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 679 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, GlycoproteinProteomic databases
PaxDbi | Q90275 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell.
By similarityGO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000003949 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 148 – 254 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 255 – 369 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 370 – 484 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 485 – 590 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 591 – 702 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 777 – 815 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 851 – 872 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 788 – 804 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 851 – 870 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
InParanoidi | Q90275 |
OrthoDBi | 191117at2759 |
PhylomeDBi | Q90275 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030051, CDH2 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF79, PTHR24027:SF79, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MYPSGGVMLG LLAALQVAVQ GTGAMPCQPG FTENEYNVMT ADVITEGQVL
60 70 80 90 100
LKVDFVDCGR GSGLRFESGD PADFRIDADG TVMAARTLQL TDRKGQSLEI
110 120 130 140 150
KAKDENSQEQ WMVHINFTQP KQVPVILFPR HSVLVKGDDS VNRVKRDWVI
160 170 180 190 200
PPVNVLENSR KQFPEELVKI QSDKDKSNTL RYSVTGPGAD QNPTGLFIID
210 220 230 240 250
PISGLLSVTK PLDREHIPNF HLRAHAVDIN GNQMENPIDI IINVIDMNDN
260 270 280 290 300
RPEFTHQIWN GTVDEGAKPG TFVMTVTSQD KDDPNTANGM LRYKILSQTP
310 320 330 340 350
ESPSSNMFTI NNKTGKIITV AAGLDREKVP QYTLIIQATD MEGNPTYGLS
360 370 380 390 400
NTATAVIRLL DVNDNAPEFT RETFHGEVPE NRVNVIVTNL TVTDKDEPGT
410 420 430 440 450
PAWNAVYRII SGDPTGRFSI PTDPVTNEGL VTVVKPVDFE MNRSFMLTVV
460 470 480 490 500
ADNEVPLASG IHRTRQSTAT VSIRVIDVNE SPNFDPNPKQ IKLEEGLPQW
510 520 530 540 550
SMLTTFTAHD PDRYMQQTIS YSKLYDPANW LEIDPNNGRI STIAVLDRES
560 570 580 590 600
PYVKNNLYNA TFMASDNGVP RASGTGTLQI YLLDINDNAP RVFPQEAEVC
610 620 630 640 650
ERPEPNAINI TAVDGDLNPN AGPYAFELPN RPSDIRRNWT LTRISGDHAQ
660 670 680 690 700
LSLKISYLES GIYELPISIT DSGNLPMSNT TYLRIKVCQC DHHGDCVDME
710 720 730 740 750
RIMAAGLGTG AIIAILICII ILLVLVLMFV MWMKRRDKER QAKQLLIDPE
760 770 780 790 800
DDVRDNILKY DEEGGGEEDQ DYDLSQLQQP DTLEPDMIKP VGIRRLDERP
810 820 830 840 850
MHSEPNYPIR SAAPHPGDIG EFIHEGLKAA DTDPTAPPYD SLLVFDYEGS
860 870 880 890
GSTAGSLSSL HSSSSGGDQD YDYLNDWGPR FRKLADMYGG NDD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG1K2E7 | G1K2E7_DANRE | Cadherin-2 | cdh2 | 893 | Annotation score: | ||
A0A2R8RN51 | A0A2R8RN51_DANRE | Cadherin-2 | cdh2 | 869 | Annotation score: | ||
A0A2R8Q5E6 | A0A2R8Q5E6_DANRE | Cadherin-2 | cdh2 | 868 | Annotation score: | ||
A0A2R8QKB4 | A0A2R8QKB4_DANRE | Cadherin-2 | cdh2 | 909 | Annotation score: | ||
A0A2R8RZF2 | A0A2R8RZF2_DANRE | Cadherin-2 | cdh2 | 782 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 510 | D → DD in CAA47890 (PubMed:7873785).Curated | 1 | |
Sequence conflicti | 530 | W → L in CAA47890 (PubMed:7873785).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF430842 mRNA Translation: AAN61915.1 AF418565 mRNA Translation: AAL59160.1 X67648 mRNA Translation: CAA47890.1 |
RefSeqi | NP_571156.2, NM_131081.2 |
Genome annotation databases
GeneIDi | 30291 |
KEGGi | dre:30291 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF430842 mRNA Translation: AAN61915.1 AF418565 mRNA Translation: AAL59160.1 X67648 mRNA Translation: CAA47890.1 |
RefSeqi | NP_571156.2, NM_131081.2 |
3D structure databases
SMRi | Q90275 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000003949 |
Proteomic databases
PaxDbi | Q90275 |
Genome annotation databases
GeneIDi | 30291 |
KEGGi | dre:30291 |
Organism-specific databases
CTDi | 1000 |
ZFINi | ZDB-GENE-990415-171, cdh2 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
InParanoidi | Q90275 |
OrthoDBi | 191117at2759 |
PhylomeDBi | Q90275 |
Enzyme and pathway databases
Reactomei | R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-418990, Adherens junctions interactions R-DRE-525793, Myogenesis R-DRE-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
PROi | PR:Q90275 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030051, CDH2 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF79, PTHR24027:SF79, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CADH2_DANRE | |
Accessioni | Q90275Primary (citable) accession number: Q90275 Secondary accession number(s): Q8UVQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | November 25, 2002 | |
Last modified: | June 2, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |