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Entry version 146 (26 Feb 2020)
Sequence version 2 (27 May 2002)
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Protein

Paired box protein Pax-2a

Gene

pax2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi19 – 145PairedPROSITE-ProRule annotationAdd BLAST127

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired box protein Pax-2a
Alternative name(s):
No isthmus protein
Pax[Zf-b]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pax2a
Synonyms:noi, pax2.1, paxzf-b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990415-8 pax2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000501771 – 410Paired box protein Pax-2aAdd BLAST410

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90268

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed during embryogenesis in the kidney, optic stalk, midbrain, otic vesicle and a row of cells along the spinal cord and the hindbrain.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First seen during the formation of neural keel. At 9-10 hours of development expression seen in two laterally located transverse stripes of cells in the rostral 1/3 of the embryo, and the two areas subsequently move towards the midline and form the posterior portion of the midbrain. Detected in the otic placode, Wolffian duct including the nephritic primordium and optic stalk at 10-12 hours. At 14-15 hours expression seen in the single cells along the spinal cord, presumably interneurons.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000028148 Expressed in ear vesicle and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q90268 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000071460

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90268

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 78PAI subdomainPROSITE-ProRule annotationAdd BLAST57
Regioni97 – 145RED subdomainPROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Paired box

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3862 Eukaryota
ENOG410ZT0S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157412

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019281_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90268

KEGG Orthology (KO)

More...
KOi
K15608

Database of Orthologous Groups

More...
OrthoDBi
592933at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90268

TreeFam database of animal gene trees

More...
TreeFami
TF315397

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00131 PAX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00027 PAIREDBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00351 PAX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 12 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q90268-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIHCKADPF SAMHLSHIGH GGVNQLGGVF VNGRPLPDVV RQRIVELAHQ
60 70 80 90 100
GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IKPGVIGGSK PKVATPKVVE
110 120 130 140 150
KIAEYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF
160 170 180 190 200
HPSSDGTGTP LSTAGHTIVP STASPPVSSA SNDPVGSYSI NGILGIPRSN
210 220 230 240 250
GEKRKRDDVL WSGNHLDGRK IGYHGSDGSG PNSDSQGSVE SLRKHLRADA
260 270 280 290 300
FTQQQLEALD RVFERPSYPD VFPTSEHIKP EQANEYSLPA LNPGLDEVKP
310 320 330 340 350
SLSTSVSSDL GSSVSQSYPV VTGREMASTT LPGYPPHVPP TGQGSYPTST
360 370 380 390 400
LAGMVPGSDF SGNPYSHPQY TTYNEAWRFS NPALLSSPYY YSAASRGSGP
410
PTAATAYDRH
Length:410
Mass (Da):44,099
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BE302826C516FD7
GO
Isoform 1 (identifier: Q90268-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R

Show »
Length:406
Mass (Da):43,748
Checksum:i5FA7AE607B8459AA
GO
Isoform 2 (identifier: Q90268-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D

Show »
Length:391
Mass (Da):42,029
Checksum:i945AA4986AE92EDB
GO
Isoform 3 (identifier: Q90268-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-334: GREMASTTLPGY → DKSAGSTVPAGH
     335-410: Missing.

Show »
Length:334
Mass (Da):35,851
Checksum:i2BBDAFFEFD23FADA
GO
Isoform 5 (identifier: Q90268-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D
     283-322: Missing.

Show »
Length:351
Mass (Da):37,950
Checksum:i8832D34E75D5F0E0
GO
Isoform 6 (identifier: Q90268-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-322: Missing.

Show »
Length:292
Mass (Da):31,410
Checksum:i3D86C3147EEBD30A
GO
Isoform 7 (identifier: Q90268-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     323-334: GREMASTTLPGY → DKSAGSTVPAGH
     335-410: Missing.

Show »
Length:330
Mass (Da):35,500
Checksum:i122C55AA129118F8
GO
Isoform 8 (identifier: Q90268-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:404
Mass (Da):43,377
Checksum:i6EDC36E73C32675F
GO
Isoform 9 (identifier: Q90268-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-224: VLWSGNHLDGRKIGYH → D
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:389
Mass (Da):41,658
Checksum:i37B68840DF11B472
GO
Isoform 10 (identifier: Q90268-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:385
Mass (Da):41,306
Checksum:i2FD08B99DB3FD5DF
GO
Isoform 11 (identifier: Q90268-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:400
Mass (Da):43,025
Checksum:iC8A1151F0D5C4610
GO
Isoform 12 (identifier: Q90268-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-224: VLWSGNHLDGRKIGYH → D

Show »
Length:395
Mass (Da):42,380
Checksum:i9629926611BDC6BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1Q6N9F1Q6N9_DANRE
Paired box protein Pax-2a
pax2a
381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QHP2F1QHP2_DANRE
Paired box protein Pax-2a
pax2a
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QEK2F1QEK2_DANRE
Paired box protein Pax-2a
pax2a
396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1R6E2F1R6E2_DANRE
Paired box protein Pax-2a
pax2a
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8JJS4B8JJS4_DANRE
Paired box protein Pax-2a
pax2a
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8JJS3B8JJS3_DANRE
Paired box protein Pax-2a
pax2a
400Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IAI2A0A0R4IAI2_DANRE
Paired box protein Pax-2a
pax2a
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QKT4F1QKT4_DANRE
Paired box protein Pax-2a
pax2a
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1R5S6F1R5S6_DANRE
Paired box protein Pax-2a
pax2a
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti74 – 79Missing in allele TM243A; no midbrain/hindbrain boundary. 6
Natural varianti79G → V in allele TY31A; no midbrain/hindbrain boundary. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00234815 – 19LSHIG → R in isoform 1, isoform 2, isoform 5, isoform 6, isoform 7, isoform 10 and isoform 11. 2 Publications5
Alternative sequenceiVSP_002350209 – 322Missing in isoform 6. CuratedAdd BLAST114
Alternative sequenceiVSP_002349209 – 224VLWSG…KIGYH → D in isoform 2, isoform 5, isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_002351283 – 322Missing in isoform 5. CuratedAdd BLAST40
Alternative sequenceiVSP_002352323 – 334GREMA…TLPGY → DKSAGSTVPAGH in isoform 3 and isoform 7. CuratedAdd BLAST12
Alternative sequenceiVSP_002353335 – 410Missing in isoform 3 and isoform 7. CuratedAdd BLAST76
Alternative sequenceiVSP_002354386 – 410SSPYY…AYDRH → MPHPGAPGLPLLPLPMTAT in isoform 8, isoform 9, isoform 10 and isoform 11. CuratedAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63961 mRNA Translation: CAA45378.1
AF067530 mRNA Translation: AAD19285.1
AF067531 mRNA Translation: AAD19286.1
AF067532 mRNA Translation: AAD19287.1
AF067533 mRNA Translation: AAD19288.1
AF067534 mRNA Translation: AAD19289.1
AF067535 mRNA Translation: AAD19290.1
AF067536 mRNA Translation: AAD19291.1
AF067537 mRNA Translation: AAD19292.1
AF067538 mRNA Translation: AAD19293.1
AF067539 mRNA Translation: AAD19294.1
AF067540 mRNA Translation: AAD19295.1
AF067541 mRNA Translation: AAD19296.1
BC066690 mRNA Translation: AAH66690.1

Protein sequence database of the Protein Information Resource

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PIRi
S23341

NCBI Reference Sequences

More...
RefSeqi
NP_571259.1, NM_131184.2 [Q90268-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSDART00000076998; ENSDARP00000071466; ENSDARG00000028148 [Q90268-3]
ENSDART00000076992; ENSDARP00000071460; ENSDARG00000028148 [Q90268-12]
ENSDART00000134424; ENSDARP00000121417; ENSDARG00000028148 [Q90268-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
30425

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:30425

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63961 mRNA Translation: CAA45378.1
AF067530 mRNA Translation: AAD19285.1
AF067531 mRNA Translation: AAD19286.1
AF067532 mRNA Translation: AAD19287.1
AF067533 mRNA Translation: AAD19288.1
AF067534 mRNA Translation: AAD19289.1
AF067535 mRNA Translation: AAD19290.1
AF067536 mRNA Translation: AAD19291.1
AF067537 mRNA Translation: AAD19292.1
AF067538 mRNA Translation: AAD19293.1
AF067539 mRNA Translation: AAD19294.1
AF067540 mRNA Translation: AAD19295.1
AF067541 mRNA Translation: AAD19296.1
BC066690 mRNA Translation: AAH66690.1
PIRiS23341
RefSeqiNP_571259.1, NM_131184.2 [Q90268-3]

3D structure databases

SMRiQ90268
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071460

Proteomic databases

PaxDbiQ90268

Genome annotation databases

EnsembliENSDART00000076998; ENSDARP00000071466; ENSDARG00000028148 [Q90268-3]
ENSDART00000076992; ENSDARP00000071460; ENSDARG00000028148 [Q90268-12]
ENSDART00000134424; ENSDARP00000121417; ENSDARG00000028148 [Q90268-6]
GeneIDi30425
KEGGidre:30425

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
30425
ZFINiZDB-GENE-990415-8 pax2a

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00940000157412
HOGENOMiCLU_019281_6_0_1
InParanoidiQ90268
KOiK15608
OrthoDBi592933at2759
PhylomeDBiQ90268
TreeFamiTF315397

Miscellaneous databases

Protein Ontology

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PROi
PR:Q90268

Gene expression databases

BgeeiENSDARG00000028148 Expressed in ear vesicle and 119 other tissues
ExpressionAtlasiQ90268 baseline

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAX2A_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90268
Secondary accession number(s): Q9PWK8
, Q9PWK9, Q9PWL0, Q9PWL1, Q9YGU5, Q9YGU6, Q9YGU7, Q9YGU8, Q9YGU9, Q9YGV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: February 26, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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