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Protein

Achaete-scute homolog 1a

Gene

ascl1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 1a
Short name:
Zash-1a
Alternative name(s):
Pituitary-absent protein
Gene namesi
Name:ascl1aImported
Synonyms:ashImported, ash1a1 Publication, ashaImported, pia1 Publication
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-980526-90 ascl1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

In pituitary absent (pia) mutants, adenohypophyseal cells fail to express hormone genes and some become apoptotic.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712351 – 196Achaete-scute homolog 1aAdd BLAST196

Proteomic databases

PaxDbiQ90259

Expressioni

Tissue specificityi

In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis, telencephalon, diencephalon, epiphysis, ventral tegmentum, neural retina and spinal cord, in discrete regions distinct from those expressing ascl1b. In the 30 hours embryo, hindbrain expression is in stripes adjacent to rhombomere boundaries.4 Publications

Developmental stagei

First detected at 12 hours post-fertilization (hpf), increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult.1 Publication

Gene expression databases

BgeeiENSDARG00000038386 Expressed in 51 organ(s), highest expression level in retina

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056004

Structurei

3D structure databases

ProteinModelPortaliQ90259
SMRiQ90259
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 130bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00530000063321
HOGENOMiHOG000013056
HOVERGENiHBG050590
InParanoidiQ90259
KOiK09067
OMAiELMRCKR
OrthoDBiEOG091G0OB6
PhylomeDBiQ90259
TreeFamiTF322889

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q90259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDITAKMEIS VNQQQFMPPA CFFASQSIQL SPTDSQCSNK SASKQAKRQR
60 70 80 90 100
SSSPELLRCK RRLNFAGFGY SLPQQQPHAV ARRNERERNR VKLVNNGFAT
110 120 130 140 150
LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV SAAFQSGVLS
160 170 180 190
PTISQNYSND MNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF
Length:196
Mass (Da):21,928
Last modified:November 1, 1996 - v1
Checksum:i462E3A35DCBA183A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14587 mRNA Translation: AAA78898.1
BX510924 Genomic DNA Translation: CAK04833.1
BX511171 Genomic DNA Translation: CAI21097.1
BC098521 mRNA Translation: AAH98521.1
PIRiI50507
RefSeqiNP_571294.1, NM_131219.1
UniGeneiDr.314

Genome annotation databases

EnsembliENSDART00000056005; ENSDARP00000056004; ENSDARG00000038386
GeneIDi30466
KEGGidre:30466

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14587 mRNA Translation: AAA78898.1
BX510924 Genomic DNA Translation: CAK04833.1
BX511171 Genomic DNA Translation: CAI21097.1
BC098521 mRNA Translation: AAH98521.1
PIRiI50507
RefSeqiNP_571294.1, NM_131219.1
UniGeneiDr.314

3D structure databases

ProteinModelPortaliQ90259
SMRiQ90259
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056004

Proteomic databases

PaxDbiQ90259

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000056005; ENSDARP00000056004; ENSDARG00000038386
GeneIDi30466
KEGGidre:30466

Organism-specific databases

CTDi30466
ZFINiZDB-GENE-980526-90 ascl1a

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00530000063321
HOGENOMiHOG000013056
HOVERGENiHBG050590
InParanoidiQ90259
KOiK09067
OMAiELMRCKR
OrthoDBiEOG091G0OB6
PhylomeDBiQ90259
TreeFamiTF322889

Miscellaneous databases

PROiPR:Q90259

Gene expression databases

BgeeiENSDARG00000038386 Expressed in 51 organ(s), highest expression level in retina

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASL1A_DANRE
AccessioniPrimary (citable) accession number: Q90259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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