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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:PAE0594
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204881 – 423Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8ZYW1

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE0594

Structurei

3D structure databases

ProteinModelPortaliQ8ZYW1
SMRiQ8ZYW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
InParanoidiQ8ZYW1
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZYW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFERAKSVF PGGVNSPARA LKHLPSPLVA KAASGAYLYT DRGKLVDYCM
60 70 80 90 100
AFGAIILGHA HPRVKKAVEE QLEKGWIYAL LTEQEVEFAE RIRRHMPSVE
110 120 130 140 150
KMRIVNTGTE ATMSAIRAAR GYTKRDVIIK FEGNFHGSHD YVLVKAGSGA
160 170 180 190 200
ATWGIPTSAG IPQEVARLTV VVPYNDIDAF IKAVREVGDR LAAVIVEPVA
210 220 230 240 250
GNYGLIIPDV EFLKALREET QRAGALLIFD EVITGFRVGL GGAQGLFGIR
260 270 280 290 300
PDLTTLGKVV GGGFPIGIFG GRGEVMDLVA PSGPVYNAGT YNAHPVSIAA
310 320 330 340 350
GLAVLKELET GEPYRIANEA AERLAKGVED VAGRLGFDVV VKRMASMFQF
360 370 380 390 400
YFKKGDVKTP QDVRESNEKM YLKLHEIALK HGVYLTPSQY EVNFTSAAHG
410 420
REVVEETLAA LEKSFQELQR EIG
Length:423
Mass (Da):46,016
Last modified:March 1, 2002 - v1
Checksum:i3AEB230212615027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL62882.1

Genome annotation databases

EnsemblBacteriaiAAL62882; AAL62882; PAE0594
KEGGipai:PAE0594
PATRICifig|178306.9.peg.426

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL62882.1

3D structure databases

ProteinModelPortaliQ8ZYW1
SMRiQ8ZYW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi178306.PAE0594

Proteomic databases

PRIDEiQ8ZYW1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL62882; AAL62882; PAE0594
KEGGipai:PAE0594
PATRICifig|178306.9.peg.426

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
InParanoidiQ8ZYW1
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSA_PYRAE
AccessioniPrimary (citable) accession number: Q8ZYW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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