Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PAE1107
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521381 – 945Leucine--tRNA ligaseAdd BLAST945

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE1107

Structurei

3D structure databases

ProteinModelPortaliQ8ZXT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
InParanoidiQ8ZXT6
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZXT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELSSLFIK MAEKWQAKWA EARVYEPEPR PGAAKFFVTA AYPYPNGAIH
60 70 80 90 100
IGHGRTYLIA DVLARFHRHM GRVVLFPMGF HYTGTPILTI AEAIASGDAT
110 120 130 140 150
VIEEYMAIYG VPKDEIEKMG NPLYLARYFH EQSKRAMQKF GLGIDWTREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRE RGLIVRGRHP VGWCPRHSMP VGAHDTKDDK
210 220 230 240 250
EPEIGQWTLI YFADGEGLVF PAATLRPETV LGVTNMWINP DAEYAVIEHN
260 270 280 290 300
GRKMVVSKDA AFRLSFQGDV RILREARGRE FVGRSVQNPV TGEWVPVYEA
310 320 330 340 350
KFVDPKVGTG VVMSVPAHAP YDYAALRDLN AVRLIPLIRV EGYGDYPAKE
360 370 380 390 400
VVERMGIKSQ TDPALEEATR EVYSAEYTKG VMREDVVGRV GAHLSEPARS
410 420 430 440 450
MLRAVFKMYF AGRPVREARE FISKWLVEAG IGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGEGRWK ELARKLVEEM AIVPPEAKAH FLATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSDGWV IESLSDSTIY MAFYTVIKRI RQFGIKPEQL
560 570 580 590 600
IKEFWDYVFL GVGTPEEVAK RTGVPPEQLK AIREEFDFWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
KAVDMYGPDP LRATLAITAE VEQDLDFRHA EAIRNAQQLM SIYSLAQRLA
710 720 730 740 750
QTAEDRSPNW LDKWLVSEIA LVLERAREAY EKVRVRQAAV EVLYNAKSVF
760 770 780 790 800
DQYLASVERP SKLAVEAARA WAVAMEPIAP HLAEEIWSIL GGEGLVVKAP
810 820 830 840 850
WPQLRPDPVA LLAKRYVDMV IDDVKRIPAF GEGVKRVVIY VNPNYAWVKA
860 870 880 890 900
ALSGDVKAVI NAGAPPQAAK RVVDIVKTLG DELRGLISAV GKFDEAEALA
910 920 930 940
SYKNYMEKAL GAPMEIYNAD DPSAPDLGSK KKVALPLRPG IYIEK
Length:945
Mass (Da):106,850
Last modified:March 1, 2002 - v1
Checksum:i2ECDFFE9EE85F243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL63260.1

Genome annotation databases

EnsemblBacteriaiAAL63260; AAL63260; PAE1107
KEGGipai:PAE1107
PATRICifig|178306.9.peg.821

Similar proteinsi

Entry informationi

Entry nameiSYL_PYRAE
AccessioniPrimary (citable) accession number: Q8ZXT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health