UniProtKB - Q8ZWT5 (TRM1_PYRAE)
Protein
tRNA (guanine(26)-N(2))-dimethyltransferase
Gene
trm1
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Functioni
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.UniRule annotation
Catalytic activityi
- guanosine26 in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N2-dimethylguanosine26 in tRNA + 2 S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.216UniRule annotation
GO - Molecular functioni
- tRNA (guanine-N2-)-methyltransferase activity Source: GO_Central
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- tRNA N2-guanine methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, RNA-binding, Transferase, tRNA-binding |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA (guanine(26)-N(2))-dimethyltransferaseUniRule annotation (EC:2.1.1.216UniRule annotation)Alternative name(s): tRNA 2,2-dimethylguanosine-26 methyltransferaseUniRule annotation tRNA(guanine-26,N(2)-N(2)) methyltransferaseUniRule annotation tRNA(m(2,2)G26)dimethyltransferaseUniRule annotation |
Gene namesi | Name:trm1UniRule annotation Ordered Locus Names:PAE1628 |
Organismi | Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) |
Taxonomic identifieri | 178306 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147688 | 1 – 363 | tRNA (guanine(26)-N(2))-dimethyltransferaseAdd BLAST | 363 |
Proteomic databases
PRIDEi | Q8ZWT5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 352 | Trm1 methyltransferaseUniRule annotationAdd BLAST | 348 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG01219 Archaea COG1867 LUCA |
HOGENOMi | HOG000229931 |
InParanoidi | Q8ZWT5 |
KOi | K00555 |
OMAi | VFYNPVM |
Family and domain databases
Gene3Di | 3.30.56.70, 1 hit |
HAMAPi | MF_00290 tRNA_dimethyltr_TRM1, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR002905 Trm1 IPR022923 TRM1_arc_bac IPR042296 tRNA_met_Trm1_C |
PANTHERi | PTHR10631 PTHR10631, 2 hits |
Pfami | View protein in Pfam PF02005 TRM, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51626 SAM_MT_TRM1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8ZWT5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRHLVLRREG GVKFYAPDPE KYGGIYSAPV FYNPAMEKNR TLSTLLLKAY
60 70 80 90 100
GKGGLVVCEP LSGTGVRGIR YAVESGVVGK LILNDISKEA VELIKKNLEI
110 120 130 140 150
NGVDAEVYNE DANVLLHKLK DSCDVVDIDP FGSPAPFIHG AFRALKEEGL
160 170 180 190 200
ICATATDTAV LVGRYPRKCL RRYGSVIVKT PFYIEVGLRN LLGYIARVAA
210 220 230 240 250
AEDYKITPLM SYWEGHYFRV CAYAARGARD ADDNFHHIAY IKYERGVRKI
260 270 280 290 300
LHAQSEGSSG PLWVGPLGDP LIINKMSEIG PYQDFLKILA EEYSISAPWF
310 320 330 340 350
YRLPEFAAGG KSPTLKEAVG VLRAAGIYAV RTHMAPDGFK ADGEYGEVLM
360
AFKRYISSAH SLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009441 Genomic DNA Translation: AAL63614.1 |
Genome annotation databases
EnsemblBacteriai | AAL63614; AAL63614; PAE1628 |
KEGGi | pai:PAE1628 |
PATRICi | fig|178306.9.peg.1203 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009441 Genomic DNA Translation: AAL63614.1 |
3D structure databases
SMRi | Q8ZWT5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 178306.PAE1628 |
Proteomic databases
PRIDEi | Q8ZWT5 |
Genome annotation databases
EnsemblBacteriai | AAL63614; AAL63614; PAE1628 |
KEGGi | pai:PAE1628 |
PATRICi | fig|178306.9.peg.1203 |
Phylogenomic databases
eggNOGi | arCOG01219 Archaea COG1867 LUCA |
HOGENOMi | HOG000229931 |
InParanoidi | Q8ZWT5 |
KOi | K00555 |
OMAi | VFYNPVM |
Family and domain databases
Gene3Di | 3.30.56.70, 1 hit |
HAMAPi | MF_00290 tRNA_dimethyltr_TRM1, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR002905 Trm1 IPR022923 TRM1_arc_bac IPR042296 tRNA_met_Trm1_C |
PANTHERi | PTHR10631 PTHR10631, 2 hits |
Pfami | View protein in Pfam PF02005 TRM, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51626 SAM_MT_TRM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRM1_PYRAE | |
Accessioni | Q8ZWT5Primary (citable) accession number: Q8ZWT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families