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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:PAE3134
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525501 – 413Probable tRNA pseudouridine synthase DAdd BLAST413

Proteomic databases

PRIDEiQ8ZTR2

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE3134

Structurei

3D structure databases

ProteinModelPortaliQ8ZTR2
SMRiQ8ZTR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 370TRUDUniRule annotationAdd BLAST204

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
InParanoidiQ8ZTR2
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZTR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEAPSFDKM LGMFYYATDT CPSGGVIKRS PEDFVVEEVL LDGTVIATSG
60 70 80 90 100
VELRPRVGNW TWIHVVKRNV DTIKLVLRLA RALGLSHRDV SVGGLKDTKA
110 120 130 140 150
VTSQIISVRG PVANLPQLPG VQFLGMWSMD KPITPSQIYG NRFTIILRDV
160 170 180 190 200
ERISCAEGAL EALKKTAAPN YYGYQRFGTI RPVTHLLGKA LLKKDPHLFF
210 220 230 240 250
EVMFCKIFSR ESEVAKRARE AACKGDYAKA LELFPKKFVE ERVFLKRLAG
260 270 280 290 300
GYDMWNAIMA IPPQILRVYI EAAQSYIFNR FLSIRMEIGP IDRPVEGDLV
310 320 330 340 350
EINRQIAYYA EGLGGEVVLP VVGAGVRMPR GKVGEALLRV LREEGLDPSA
360 370 380 390 400
FLKMPRGLRV YGTYRRVRLE PAGFEYKIMG NDVFMQFTLP RGSYATVLLR
410
EVVKPAEPHK HGF
Length:413
Mass (Da):46,357
Last modified:March 1, 2002 - v1
Checksum:iC533FDF84538791A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL64697.1

Genome annotation databases

EnsemblBacteriaiAAL64697; AAL64697; PAE3134
KEGGipai:PAE3134
PATRICifig|178306.9.peg.2356

Similar proteinsi

Entry informationi

Entry nameiTRUD_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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