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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbon dioxide fixation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:PAE3416
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003096071 – 460Phosphoenolpyruvate carboxylaseAdd BLAST460

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE3416

Structurei

3D structure databases

ProteinModelPortaliQ8ZT64
SMRiQ8ZT64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04435 Archaea
COG1892 LUCA
HOGENOMiHOG000009826
InParanoidiQ8ZT64
KOiK01595
OMAiDEVMSDF
OrthoDBiPOG093Z01LI

Family and domain databases

HAMAPiMF_01904 PEPcase_type2, 1 hit
InterProiView protein in InterPro
IPR007566 PEP_COase_arc-type
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PfamiView protein in Pfam
PF14010 PEPcase_2, 1 hit
PIRSFiPIRSF006677 UCP006677, 1 hit
SUPFAMiSSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR02751 PEPCase_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZT64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYIPCLMCTQ HPDSTVKITA GEEVDEAVVA FLAYGCDEVM VDYEGKATPY
60 70 80 90 100
SQPRDVASKA LALGLPLGER FFITPRVPNP RLEDFERSML SLEAAVLANS
110 120 130 140 150
YSQRAAGVQA VKWVVLPMTE DVETMAFVYK ALDMKARDLA ELNAVKRDSS
160 170 180 190 200
IELIPLVEDA MRQIKIESFI KALFRTAAQS GRILEHMRIF LGISDSAVRH
210 220 230 240 250
GHMASALAMV KALGQISEIN RDGEFKISPI VGMGSPPFRG GLNNPHLAVP
260 270 280 290 300
EAAQYAGYKT ATIQSAVRYD VSYAEYQKVR EAILSVYTPR RLHVEEAWIT
310 320 330 340 350
KASELYREAI RPYIGKIAEL ANAIPSTRDR VSWREYGRVI EGVEWRVPRA
360 370 380 390 400
IVYTATWYFA GVPPTLLDAR FIAWAYKNDL LDDVLRALPA TVEEWKFESR
410 420 430 440 450
FYSRERAEKT LGGEIVKDID NAFDILGIKP EPDRTYITLL NSADTQPHAI
460
ALGRIRGFLG
Length:460
Mass (Da):51,486
Last modified:March 1, 2002 - v1
Checksum:iA2FD72765E7E385C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL64899.1

Genome annotation databases

EnsemblBacteriaiAAL64899; AAL64899; PAE3416
KEGGipai:PAE3416
PATRICifig|178306.9.peg.2568

Similar proteinsi

Entry informationi

Entry nameiCAPPA_PYRAE
AccessioniPrimary (citable) accession number: Q8ZT64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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