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Protein

H(+)/Cl(-) exchange transporter ClcA

Gene

clcA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Chloride1
Sitei148Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport1
Sitei203Mediates proton transfer from the protein to the inner aqueous phase1
Binding sitei356Chloride; via amide nitrogen1
Binding sitei357Chloride; via amide nitrogen1
Binding sitei445Chloride1

GO - Molecular functioni

  • chloride ion binding Source: GO_Central
  • solute:proton antiporter activity Source: GO_Central
  • voltage-gated chloride channel activity Source: GO_Central

Keywordsi

Biological processAntiport, Ion transport, Transport
LigandChloride

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-205-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
H(+)/Cl(-) exchange transporter ClcA
Gene namesi
Name:clcA
Synonyms:eriC
Ordered Locus Names:STM0203
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicAdd BLAST32
Transmembranei33 – 69HelicalAdd BLAST37
Topological domaini70 – 76Periplasmic7
Transmembranei77 – 100HelicalAdd BLAST24
Intramembranei109 – 116Helical8
Topological domaini117 – 123Cytoplasmic7
Transmembranei124 – 141HelicalAdd BLAST18
Transmembranei148 – 166HelicalAdd BLAST19
Topological domaini167 – 176Cytoplasmic10
Intramembranei177 – 189HelicalAdd BLAST13
Intramembranei190 – 192Note=Loop between two helices3
Intramembranei193 – 201Helical9
Topological domaini202 – 214CytoplasmicAdd BLAST13
Transmembranei215 – 232HelicalAdd BLAST18
Topological domaini233 – 252PeriplasmicAdd BLAST20
Transmembranei253 – 281HelicalAdd BLAST29
Topological domaini282 – 287Cytoplasmic6
Transmembranei288 – 308HelicalAdd BLAST21
Topological domaini309 – 329PeriplasmicAdd BLAST21
Transmembranei330 – 349HelicalAdd BLAST20
Topological domaini350 – 354Cytoplasmic5
Transmembranei355 – 378HelicalAdd BLAST24
Topological domaini379 – 386Periplasmic8
Intramembranei387 – 401HelicalAdd BLAST15
Intramembranei402 – 404Note=Loop between two helices3
Intramembranei405 – 416HelicalAdd BLAST12
Intramembranei417 – 421Note=Loop between two helices5
Transmembranei422 – 438HelicalAdd BLAST17
Topological domaini439 – 473CytoplasmicAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944781 – 473H(+)/Cl(-) exchange transporter ClcAAdd BLAST473

Proteomic databases

PaxDbiQ8ZRP8

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi99287.STM0203

Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8ZRP8
SMRiQ8ZRP8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZRP8

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 110Selectivity filter part_15
Motifi146 – 150Selectivity filter part_25
Motifi355 – 359Selectivity filter part_35

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CMQ Bacteria
COG0038 LUCA
HOGENOMiHOG000257546
KOiK03281
OMAiFQRIHGG
PhylomeDBiQ8ZRP8

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
HAMAPiMF_01128 CLC_ClcA, 1 hit
InterProiView protein in InterPro
IPR023861 Cl-channel_ClcA
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
SUPFAMiSSF81340 SSF81340, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZRP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTDTSTFLA QQIVRLRRRD QIRRLMQRDK TPLAILFMAA VVGTLTGLVG
60 70 80 90 100
VAFEKAVSWV QNMRIGALVQ VADHAFLLWP LAFILSALLA MVGYFLVRKF
110 120 130 140 150
APEAGGSGIP EIEGALEELR PVRWWRVLPV KFIGGMGTLG AGMVLGREGP
160 170 180 190 200
TVQIGGNLGR MVLDVFRMRS AEARHTLLAT GAAAGLSAAF NAPLAGILFI
210 220 230 240 250
IEEMRPQFRY NLISIKAVFT GVIMSSIVFR IFNGEAPIIE VGKLSDAPVN
260 270 280 290 300
TLWLYLILGI IFGCVGPVFN SLVLRTQDMF QRFHGGEIKK WVLMGGAIGG
310 320 330 340 350
LCGILGLIEP AAAGGGFNLI PIAAAGNFSV GLLLFIFITR VVTTLLCFSS
360 370 380 390 400
GAPGGIFAPM LALGTLLGTA FGMAAAVLFP QYHLEAGTFA IAGMGALMAA
410 420 430 440 450
SVRAPLTGIV LVLEMTDNYQ LILPMIITCL GATLLAQFLG GKPLYSTILA
460 470
RTLAKQDAEQ AEKNQNAPAD ENT
Length:473
Mass (Da):50,481
Last modified:March 5, 2002 - v1
Checksum:i7134B5A5510A65A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19167.1
RefSeqiNP_459208.1, NC_003197.2
WP_000845427.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19167; AAL19167; STM0203
GeneIDi1251721
KEGGistm:STM0203
PATRICifig|99287.12.peg.216

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19167.1
RefSeqiNP_459208.1, NC_003197.2
WP_000845427.1, NC_003197.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPLX-ray3.00A/B/C/D1-473[»]
ProteinModelPortaliQ8ZRP8
SMRiQ8ZRP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0203

Proteomic databases

PaxDbiQ8ZRP8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19167; AAL19167; STM0203
GeneIDi1251721
KEGGistm:STM0203
PATRICifig|99287.12.peg.216

Phylogenomic databases

eggNOGiENOG4105CMQ Bacteria
COG0038 LUCA
HOGENOMiHOG000257546
KOiK03281
OMAiFQRIHGG
PhylomeDBiQ8ZRP8

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-205-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ8ZRP8

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
HAMAPiMF_01128 CLC_ClcA, 1 hit
InterProiView protein in InterPro
IPR023861 Cl-channel_ClcA
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
SUPFAMiSSF81340 SSF81340, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLCA_SALTY
AccessioniPrimary (citable) accession number: Q8ZRP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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