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Entry version 76 (11 Dec 2019)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Putative inner membrane protein

Gene

STM0285

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SENT99287:STM0285-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative inner membrane proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:STM0285Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 63HelicalSequence analysisAdd BLAST20
Transmembranei70 – 91HelicalSequence analysisAdd BLAST22
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei530 – 547HelicalSequence analysisAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8ZRL2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini265 – 538ImcF-related_NInterPro annotationAdd BLAST274
Domaini590 – 915IcmF-relatedInterPro annotationAdd BLAST326
Domaini1037 – 1236IcmF_CInterPro annotationAdd BLAST200

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CU3 Bacteria
COG3523 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143195

KEGG Orthology (KO)

More...
KOi
K11891

Identification of Orthologs from Complete Genome Data

More...
OMAi
RAEIFRF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8ZRL2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009612 IcmF-related
IPR025743 IcmF-related_N_dom
IPR010623 IcmF_C
IPR027417 P-loop_NTPase
IPR017731 T6SS_IcmF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06761 IcmF-related, 1 hit
PF06744 IcmF_C, 1 hit
PF14331 ImcF-related_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03348 VI_IcmF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8ZRL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKFLSLLFS RRALAVVGVL VLALLVWFVG PLVSFDTLRP LASVGSRVVT
60 70 80 90 100
IALLLMLLVL WLVNWSMSII GISVLCLAIG FVTPLLALGD VHPFAPLWVR
110 120 130 140 150
LTLIGFILLM YALYGLYRLW RALRMDEQLL RRFLHPRGEE VPVAGEIKAD
160 170 180 190 200
LRTVNHIVTQ AIRQLRQLRV DMPGWRKIFE GKRFLYELPW FMVVGSPGDG
210 220 230 240 250
KTTALLNTGL QFPLAEQMEQ TSRILTVPGG GTLHCDWWFT NEAVLIDTAG
260 270 280 290 300
RYARHDDGGE ASAAQRNAGE WQGFLGLLRK HRPGAPLNGV ILTLNVADLT
310 320 330 340 350
AQSPAERLAA CAALRARLAE LRETLGIRFP VYLVVTKMDL LPGFSEYFRT
360 370 380 390 400
LTSHLRAQIW GFTLPYSRRR KAGDPQALHA ACAQELARLT LRLDQGLDTR
410 420 430 440 450
LQEEYDLKSR QRLYTFPREF AALGEPLLEA IEQIFLDSKF DATQLNNTLR
460 470 480 490 500
GVFFTSAAQA QADAVADQLS IWQRFVRAIK TARGESSASL PHALPDGNRS
510 520 530 540 550
YFLHDLLTQF IFREAHLVEP NLQWAWRYRL LRLGGHLLVL VLAFLLWQGM
560 570 580 590 600
QTSQQTNGDY LNEISARATR LDGDVKAYTG KPAMAPVPAL LDSARELSAW
610 620 630 640 650
PELDPDAPPL AWRYGLYSVP PVTDSVASLY NRLLDQLLLP PLVKRMEYVL
660 670 680 690 700
ADAIARQDSK AAYDALRIYL LLNLDKDHED KYNAAEIQSW VINDLGNSDS
710 720 730 740 750
VAGFGGRAAV LTHIEALFDG SRVVHSPYEK DEALIRQARA FLDGHTSTER
760 770 780 790 800
IYARALAAME SEAPQEFTLV RAVGADAGTV FVRSNGAPLD RGVPGIFTRE
810 820 830 840 850
GYRELFDKRL PEFVAAATAN DGWVMGREST PKKLTDSLRS QIPGQEQSVA
860 870 880 890 900
REVRRLYLTE YARRWQDFLD SIHSINSAGE EGSSGLAYDL QVLRTLASPD
910 920 930 940 950
SPLMRLGKAV VEQTTLVPPP DPQARQKQLA QRASGNAGKV VQTAKLFQDI
960 970 980 990 1000
HPEERLEKTL VDDRFAALRE VIAGRTDGGQ SGGGTMQIAS LLTMLNEYYT
1010 1020 1030 1040 1050
QLTIADSALA AGTLPARITA ADKLQLEAAK LPAPLKNILL DLTKQGTRKI
1060 1070 1080 1090 1100
NAGTGDVLNT QMEAMMGDDC RDAIDGRYPF ADSPQEVSAE DFNRIFASGG
1110 1120 1130 1140 1150
VLDAFWSKQL APLADTASDP WRYKPTEGNM TLQGPDLTPF QQAKQIRSVF
1160 1170 1180 1190 1200
FNSEGGKKFS WSMQISVVDM DPAIMELVID IDGQVLRYAH GPDRPLKVTW
1210 1220 1230 1240 1250
PGPRNGSMAE ITASPRIRQD TSTLLTGGPW ALFHLLDAGM VQETAVRGRQ
1260 1270 1280
LVEYDFDGRR VVLEITAGRD FNPVSRELLQ NFSCPARAL
Length:1,289
Mass (Da):143,173
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9104EA78DCA30EBB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19242.1

NCBI Reference Sequences

More...
RefSeqi
NP_459283.1, NC_003197.2
WP_001168955.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL19242; AAL19242; STM0285

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1251804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM0285

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.295

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19242.1
RefSeqiNP_459283.1, NC_003197.2
WP_001168955.1, NC_003197.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ8ZRL2

Genome annotation databases

EnsemblBacteriaiAAL19242; AAL19242; STM0285
GeneIDi1251804
KEGGistm:STM0285
PATRICifig|99287.12.peg.295

Phylogenomic databases

eggNOGiENOG4105CU3 Bacteria
COG3523 LUCA
HOGENOMiHOG000143195
KOiK11891
OMAiRAEIFRF
PhylomeDBiQ8ZRL2

Enzyme and pathway databases

BioCyciSENT99287:STM0285-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR009612 IcmF-related
IPR025743 IcmF-related_N_dom
IPR010623 IcmF_C
IPR027417 P-loop_NTPase
IPR017731 T6SS_IcmF
PfamiView protein in Pfam
PF06761 IcmF-related, 1 hit
PF06744 IcmF_C, 1 hit
PF14331 ImcF-related_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03348 VI_IcmF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8ZRL2_SALTY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ZRL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: December 11, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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