Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardiolipin synthase B

Gene

clsB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113UniRule annotation1
Active sitei115UniRule annotation1
Active sitei120UniRule annotation1
Active sitei290UniRule annotation1
Active sitei292UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-813-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase BUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsBUniRule annotation
Synonyms:ybhO
Ordered Locus Names:STM0812
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012871 – 413Cardiolipin synthase BAdd BLAST413

Proteomic databases

PaxDbiQ8ZQP4
PRIDEiQ8ZQP4

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0812

Structurei

3D structure databases

ProteinModelPortaliQ8ZQP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 135PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini285 – 312PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DZQ Bacteria
COG1502 LUCA
HOGENOMiHOG000264393
KOiK06131
OMAiVLFLQMW
PhylomeDBiQ8ZQP4

Family and domain databases

HAMAPiMF_01917 Cardiolipin_synth_ClsB, 1 hit
InterProiView protein in InterPro
IPR030872 Cardiolipin_synth_ClsB
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q8ZQP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCGWREGNQ IQLLENGDQF YPAVFEAIAQ AQQKIILETF ILFEDEVGKK
60 70 80 90 100
LHTALLKAAQ RGVKAEVLLD GYGSPDLSDA FVGELTSAGV IFRYYDPRPR
110 120 130 140 150
LLGLRTNIFR RMHRKIVVID DRIAFVGGIN YSAEHMSDYG PQAKQDYAVR
160 170 180 190 200
VEGPVVADIL QFEVENLPGQ SPARRWWKRH HQAEENRHPG EAQALFVWRD
210 220 230 240 250
NEEHRDDIER HYLKMLTQAK REVIIANAYF FPGYRLLHAM RKAARRGVSV
260 270 280 290 300
KLIVQGEPDM PIVKVGARLL YNYLVKGGVQ VYEYRRRPLH GKVALMDDHW
310 320 330 340 350
ATVGSSNLDP LSLSLNLEAN LIIHDRTFNQ TLRDNLQGII VNDCKQVDES
360 370 380 390 400
MLPKRTWWNL TKSVLAFHFL RHFPALVGWL PAHTPHLAQV PPPAQPEMET
410
QDRVDPENTG VKP
Length:413
Mass (Da):47,302
Last modified:March 1, 2002 - v1
Checksum:i0710F4573A674072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19749.1
RefSeqiNP_459790.1, NC_003197.2
WP_000649648.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19749; AAL19749; STM0812
GeneIDi1252332
KEGGistm:STM0812
PATRICifig|99287.12.peg.846

Similar proteinsi

Entry informationi

Entry nameiCLSB_SALTY
AccessioniPrimary (citable) accession number: Q8ZQP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again