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UniProtKB - Q8ZPU8 (ASTE_SALTY)
Protein
Succinylglutamate desuccinylase
Gene
astE
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Functioni
Transforms N2-succinylglutamate into succinate and glutamate.
UniRule annotationCatalytic activityi
- EC:3.5.1.96UniRule annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
: L-arginine degradation via AST pathway Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotation This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | ZincUniRule annotation | 1 | |
Metal bindingi | 56 | ZincUniRule annotation | 1 | |
Metal bindingi | 147 | ZincUniRule annotation | 1 | |
Active sitei | 210 | UniRule annotation | 1 |
GO - Molecular functioni
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: GO_Central
- hydrolase activity, acting on ester bonds Source: UniProtKB-UniRule
- succinylglutamate desuccinylase activity Source: UniProtKB-EC
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- arginine catabolic process to glutamate Source: UniProtKB-UniRule
- arginine catabolic process to succinate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Hydrolase |
Biological process | Arginine metabolism |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00185;UER00283 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:astEUniRule annotation Ordered Locus Names:STM1307 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174647 | 1 – 322 | Succinylglutamate desuccinylaseAdd BLAST | 322 |
Proteomic databases
PaxDbi | Q8ZPU8 |
Expressioni
Inductioni
By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.1 Publication
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_071608_0_0_6 |
OMAi | KRYLHSD |
PhylomeDBi | Q8ZPU8 |
Family and domain databases
CDDi | cd03855, M14_ASTE, 1 hit |
HAMAPi | MF_00767, Arg_catab_AstE, 1 hit |
InterProi | View protein in InterPro IPR007036, Aste_AspA IPR016681, SuccinylGlu_desuccinylase |
Pfami | View protein in Pfam PF04952, AstE_AspA, 1 hit |
PIRSFi | PIRSF017020, AstE, 1 hit |
TIGRFAMsi | TIGR03242, arg_catab_astE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8ZPU8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNFLALTLS GTTPRVTQGK GAGFRWRWLG HGLLELTPDA PVDRALILSA
60 70 80 90 100
GIHGNETAPV EMLDKLLSAL YSGSLTLTWR VLVVLGNPQA LAAGIRYCHS
110 120 130 140 150
DMNRMFGGRW QSFAESDETR RARELELSLE TFFSSGQARV RWHLDLHTAI
160 170 180 190 200
RGSHHLRFGV LPQRDRPWET DFLAWLGAAG LEALVFHQAP GGTFTHFSSE
210 220 230 240 250
HFGALSCTLE LGKALPFRQN DLTQFNVTSQ ALSALLSGVE TSTSFSPPLR
260 270 280 290 300
YRVVSQITRH SDKFALYMDA QTLNFTAFAK GTLLAEEGDK RVTVTHDVEY
310 320
VLFPNPSVAC GLRAGLMLER LP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE006468 Genomic DNA Translation: AAL20232.1 |
RefSeqi | NP_460273.1, NC_003197.2 WP_000368454.1, NC_003197.2 |
Genome annotation databases
EnsemblBacteriai | AAL20232; AAL20232; STM1307 |
GeneIDi | 1252825 |
KEGGi | stm:STM1307 |
PATRICi | fig|99287.12.peg.1389 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE006468 Genomic DNA Translation: AAL20232.1 |
RefSeqi | NP_460273.1, NC_003197.2 WP_000368454.1, NC_003197.2 |
3D structure databases
SMRi | Q8ZPU8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 99287.STM1307 |
Proteomic databases
PaxDbi | Q8ZPU8 |
Genome annotation databases
EnsemblBacteriai | AAL20232; AAL20232; STM1307 |
GeneIDi | 1252825 |
KEGGi | stm:STM1307 |
PATRICi | fig|99287.12.peg.1389 |
Phylogenomic databases
HOGENOMi | CLU_071608_0_0_6 |
OMAi | KRYLHSD |
PhylomeDBi | Q8ZPU8 |
Enzyme and pathway databases
UniPathwayi | UPA00185;UER00283 |
Family and domain databases
CDDi | cd03855, M14_ASTE, 1 hit |
HAMAPi | MF_00767, Arg_catab_AstE, 1 hit |
InterProi | View protein in InterPro IPR007036, Aste_AspA IPR016681, SuccinylGlu_desuccinylase |
Pfami | View protein in Pfam PF04952, AstE_AspA, 1 hit |
PIRSFi | PIRSF017020, AstE, 1 hit |
TIGRFAMsi | TIGR03242, arg_catab_astE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASTE_SALTY | |
Accessioni | Q8ZPU8Primary (citable) accession number: Q8ZPU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families