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Protein

Malto-oligosyltrehalose trehalohydrolase

Gene

STM1560

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.UniRule annotation

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei261NucleophileUniRule annotation1
Active sitei296Proton donorUniRule annotation1
Metal bindingi297Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi319MagnesiumCombined sources1
Metal bindingi320Magnesium; via carbonyl oxygenCombined sources1
Sitei393Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
LigandMagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1577-MONOMER
UniPathwayiUPA00299

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48
GH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Malto-oligosyltrehalose trehalohydrolaseUniRule annotation (EC:3.2.1.141UniRule annotation)
Short name:
MTHaseUniRule annotation
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolaseUniRule annotation
Maltooligosyl trehalose trehalohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:STM1560Imported
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ8ZPF0
PRIDEiQ8ZPF0

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1560

Structurei

3D structure databases

ProteinModelPortaliQ8ZPF0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZPF0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 453AamyInterPro annotationAdd BLAST342

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C9C Bacteria
COG0296 LUCA
HOGENOMiHOG000155668
KOiK01236
OMAiFTPMLFM
PhylomeDBiQ8ZPF0

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR022567 DUF3459
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR012768 Trehalose_TreZ
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF11941 DUF3459, 1 hit
PIRSFiPIRSF006337 Trehalose_TreZ, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR02402 trehalose_TreZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZPF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKIFCKSW GAEYIAADVV RFRLWATGQQ KVMLRLAGKD QEMQANGDGW
60 70 80 90 100
FTLDVAGVTP GTEYNFVLSD GMVVPDPASR AQKTDVNGPS YVVDPGSYTW
110 120 130 140 150
RNTGWKGSRW EQAVVYEMHT GTFTPEGTFR AAIAKLPYLA ELGVTVIEVM
160 170 180 190 200
PVAQFGGERG WGYDGVLLYA PHSAYGTPDD FKAFIDAAHG YGLSVVLDIV
210 220 230 240 250
LNHFGPEGNY LPLLAPAFFH KERMTPWGNG IAYDVDAVRR YIIEAPLYWL
260 270 280 290 300
TEYHLDGLRF DAIDQIEDSS ARHVLVEIAQ RIREDITDRP IHLTTEDSRN
310 320 330 340 350
IISLHPRDQD GNAPLFTAEW NDDFHNAVHV FATGETQAYY NDFADAPEKH
360 370 380 390 400
LARALAEGFA YQGEISPQTG EPRGVKSTGQ PPVAFVDFIQ NHDQVGNRAQ
410 420 430 440 450
GDRLITLAGA ERTKVLLATL LLSPHIPLLF MGEEYGESRP FLFFTDFHGD
460 470 480 490 500
LARAVREGRA KEFADHAGEN VPDPNAPETF QRSKLNWKQQ HSEEGKAWLA
510 520 530 540 550
FTRELLLLRQ KHIVPLLSAA RESSGTVLQT APGFIAVSWR FPGGTLSLAL
560 570 580 590
NISATTVLLP DLPGKTLFAW PNESTGSLSQ HSLIVRLAQG ESAS
Length:594
Mass (Da):65,774
Last modified:March 1, 2002 - v1
Checksum:iB4C685D611C7E38B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20478.1
RefSeqiNP_460519.1, NC_003197.2
WP_000095534.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20478; AAL20478; STM1560
GeneIDi1253078
KEGGistm:STM1560
PATRICifig|99287.12.peg.1651

Entry informationi

Entry nameiQ8ZPF0_SALTY
AccessioniPrimary (citable) accession number: Q8ZPF0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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