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Protein

Ribosomal RNA small subunit methyltransferase F

Gene

rsmF

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1407) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1407) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149S-adenosyl-L-methionineUniRule annotation1
Binding sitei176S-adenosyl-L-methionineUniRule annotation1
Binding sitei194S-adenosyl-L-methionineUniRule annotation1
Active sitei247NucleophileUniRule annotation1

GO - Molecular functioni

  • RNA binding Source: UniProtKB-KW
  • rRNA (cytosine-C5-)-methyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1866-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase FUniRule annotation (EC:2.1.1.178UniRule annotation)
Alternative name(s):
16S rRNA m5C1407 methyltransferaseUniRule annotation
rRNA (cytosine-C(5)-)-methyltransferase RsmFUniRule annotation
Gene namesi
Name:rsmFUniRule annotation
Ordered Locus Names:STM1850
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850081 – 479Ribosomal RNA small subunit methyltransferase FAdd BLAST479

Proteomic databases

PaxDbiQ8ZNZ2
PRIDEiQ8ZNZ2

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1850

Structurei

3D structure databases

ProteinModelPortaliQ8ZNZ2
SMRiQ8ZNZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 131S-adenosyl-L-methionine bindingUniRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYJ Bacteria
COG0144 LUCA
COG3270 LUCA
HOGENOMiHOG000218115
KOiK11392
OMAiDPLFHAG
PhylomeDBiQ8ZNZ2

Family and domain databases

HAMAPiMF_01579 16SrRNA_methyltr_F, 1 hit
InterProiView protein in InterPro
IPR018314 Fmu/NOL1/Nop2p_CS
IPR031341 Methyltr_RsmF_N
IPR001678 MeTrfase_RsmB/NOP2
IPR027391 Nol1_Nop2_Fmu_2
IPR011023 Nop2p
IPR023267 RCMT
IPR023545 rRNA_ssu_MeTfrase_F
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01189 Methyltr_RsmB-F, 1 hit
PF17125 Methyltr_RsmF_N, 1 hit
PF13636 Methyltranf_PUA, 1 hit
PRINTSiPR02008 RCMTFAMILY
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00446 nop2p, 1 hit
PROSITEiView protein in PROSITE
PS01153 NOL1_NOP2_SUN, 1 hit
PS51686 SAM_MT_RSMB_NOP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZNZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQHAVYFPD AFLTQMREAM PSTLSFDEFI SACQRPLRRS IRINTLKISV
60 70 80 90 100
ADFLALIAPY GWSLTPIPWC HEGFWIERDD EEALPLGSTA EHLSGLFYIQ
110 120 130 140 150
EASSMLPVAA LFADDNHPQR VMDMAAAPGS KTTQIAARMG NRGAILANEF
160 170 180 190 200
SASRVKVLHA NISRCGIANT ALTHFDGRVF GAALPEMFDA ILLDAPCSGE
210 220 230 240 250
GVVRKDPDAL KNWSPESNLD IAATQRELLD SAFHALRPGG TLVYSTCTLN
260 270 280 290 300
RQENEAVCLW LKETYADAVE FLPLGDLFPD ADRALTPEGF LHVFPQIYDC
310 320 330 340 350
EGFFVARLRK MSSLPAMPAP GYKVGAFPFT PLKGREALHV TQAANAVGLL
360 370 380 390 400
WDENLHLWQR EKEVWLFPAE IESLIGKVRF SRLGIKLAES HNKGYRWQHE
410 420 430 440 450
ATIALACPTH AHAFELSVQE AEEWYRGRDI YPQTPPAADD VLVTFQHQPL
460 470
GLAKRIGARI KNSYPRELVR DGKLFTGNS
Length:479
Mass (Da):53,291
Last modified:March 1, 2002 - v1
Checksum:iEE206CA4B2D0FF7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20765.1
RefSeqiNP_460806.1, NC_003197.2
WP_001542138.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20765; AAL20765; STM1850
GeneIDi1253369
KEGGistm:STM1850
PATRICifig|99287.12.peg.1952

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20765.1
RefSeqiNP_460806.1, NC_003197.2
WP_001542138.1, NC_003197.2

3D structure databases

ProteinModelPortaliQ8ZNZ2
SMRiQ8ZNZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1850

Proteomic databases

PaxDbiQ8ZNZ2
PRIDEiQ8ZNZ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20765; AAL20765; STM1850
GeneIDi1253369
KEGGistm:STM1850
PATRICifig|99287.12.peg.1952

Phylogenomic databases

eggNOGiENOG4105CYJ Bacteria
COG0144 LUCA
COG3270 LUCA
HOGENOMiHOG000218115
KOiK11392
OMAiDPLFHAG
PhylomeDBiQ8ZNZ2

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1866-MONOMER

Family and domain databases

HAMAPiMF_01579 16SrRNA_methyltr_F, 1 hit
InterProiView protein in InterPro
IPR018314 Fmu/NOL1/Nop2p_CS
IPR031341 Methyltr_RsmF_N
IPR001678 MeTrfase_RsmB/NOP2
IPR027391 Nol1_Nop2_Fmu_2
IPR011023 Nop2p
IPR023267 RCMT
IPR023545 rRNA_ssu_MeTfrase_F
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01189 Methyltr_RsmB-F, 1 hit
PF17125 Methyltr_RsmF_N, 1 hit
PF13636 Methyltranf_PUA, 1 hit
PRINTSiPR02008 RCMTFAMILY
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00446 nop2p, 1 hit
PROSITEiView protein in PROSITE
PS01153 NOL1_NOP2_SUN, 1 hit
PS51686 SAM_MT_RSMB_NOP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSMF_SALTY
AccessioniPrimary (citable) accession number: Q8ZNZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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