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Protein

Probable diguanylate cyclase DgcQ

Gene

dgcQ

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).By similarity

Catalytic activityi

2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

Pathwayi: 3',5'-cyclic di-GMP biosynthesis

This protein is involved in the pathway 3',5'-cyclic di-GMP biosynthesis, which is part of Purine metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway 3',5'-cyclic di-GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436MagnesiumBy similarity1
Sitei441Transition state stabilizerSequence analysis1
Binding sitei444SubstrateBy similarity1
Binding sitei449Substrate; via carbonyl oxygenBy similarity1
Binding sitei453SubstrateBy similarity1
Active sitei479Proton acceptorSequence analysis1
Metal bindingi479MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCellulose biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2005-MONOMER
UniPathwayiUPA00599
UPA00694

Names & Taxonomyi

Protein namesi
Recommended name:
Probable diguanylate cyclase DgcQBy similarity (EC:2.7.7.65By similarity)
Short name:
DGCBy similarity
Alternative name(s):
Cellulose synthesis regulatory proteinBy similarity
Gene namesi
Name:dgcQBy similarity
Synonyms:yedQ
Ordered Locus Names:STM1987
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001691001 – 570Probable diguanylate cyclase DgcQAdd BLAST570

Proteomic databases

PaxDbiQ8ZNT5

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM1987

Structurei

3D structure databases

ProteinModelPortaliQ8ZNT5
SMRiQ8ZNT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 563GGDEFPROSITE-ProRule annotationAdd BLAST136

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
KOiK21085
OMAiWLVIRRM

Family and domain databases

CDDicd01949 GGDEF, 1 hit
InterProiView protein in InterPro
IPR033416 CHASE7
IPR000160 GGDEF_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF17151 CHASE7, 1 hit
PF00990 GGDEF, 1 hit
SMARTiView protein in SMART
SM00267 GGDEF, 1 hit
SUPFAMiSSF55073 SSF55073, 1 hit
TIGRFAMsiTIGR00254 GGDEF, 1 hit
PROSITEiView protein in PROSITE
PS50887 GGDEF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZNT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHETLLDNQ GWFKKLARRF GPGHVVNTCF LIVMLFSTLL TWREVMILKD
60 70 80 90 100
AYVASQRNHL GSVANVLDRQ LQFNMDRLIF LRNGMHEALV APLAFSALQS
110 120 130 140 150
AVTQFEQRRV RHFWQLELDK RRTLPLYGVS DQFVARTTLL SRESRDLANE
160 170 180 190 200
LTATLELGYL ARLARSSAML ALETMYVSRS GFYLSTLPTA YGSDIVSRYY
210 220 230 240 250
QYVTQPWFIE QSQRRNSQRG VRWFTSAQPY VTDEQKKVTA SLPLDHDNYW
260 270 280 290 300
YGVLAMDIPV ASLQRFLRDA AEKDIEGEYQ LYDNHLRLLT DSAPEQQTAN
310 320 330 340 350
TLNDRERALL AREIEKDTLG GLRLGTHYVS WERLDHFDGI LLRVHTLREG
360 370 380 390 400
IQGNFGSISI ALTLLWGLFT AMLLISWGVI RHMVKNMFVL QNSLQWQAWH
410 420 430 440 450
DPLTRLYNRG ALFEKASRLA KRYREARQPF SVIQLDLDYF KSVNDRFGHQ
460 470 480 490 500
AGDRVLSHAA GLIGSTIRAH DIAGRVGGEE FCIVLPGATK AQALQIAERI
510 520 530 540 550
RQRINDKEIL VTKSTTLRIS ASMGISSAEE YGDYDFEQLQ SLADKRLYYA
560 570
KQSGRNRICA SDATQEREKK
Length:570
Mass (Da):65,430
Last modified:March 5, 2002 - v1
Checksum:iBF8FDF0CF8949925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20897.1
RefSeqiNP_460938.1, NC_003197.2
WP_001119821.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20897; AAL20897; STM1987
GeneIDi1253508
KEGGistm:STM1987
PATRICifig|99287.12.peg.2103

Similar proteinsi

Entry informationi

Entry nameiDGCQ_SALTY
AccessioniPrimary (citable) accession number: Q8ZNT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health