Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arabinose 5-phosphate isomerase KdsD

Gene

kdsD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).By similarity

Catalytic activityi

D-arabinose 5-phosphate = D-ribulose 5-phosphate.

Pathwayi: 3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Arabinose 5-phosphate isomerase KdsD (kdsD)
  2. 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
  3. 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (kdsC)
This subpathway is part of the pathway 3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate, the pathway 3-deoxy-D-manno-octulosonate biosynthesis and in Carbohydrate biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59Catalytically relevantBy similarity1
Metal bindingi82ZincBy similarity1
Binding sitei82SubstrateBy similarity1
Binding sitei88SubstrateBy similarity1
Sitei111Catalytically relevantBy similarity1
Sitei152Catalytically relevantBy similarity1
Sitei193Catalytically relevantBy similarity1
Binding sitei275SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Lipopolysaccharide biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3349-MONOMER
UniPathwayi
UPA00030

UPA00357;UER00473

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose 5-phosphate isomerase KdsD (EC:5.3.1.13)
Short name:
API
Short name:
L-API
Gene namesi
Name:kdsD
Ordered Locus Names:STM3315
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3110

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001365791 – 328Arabinose 5-phosphate isomerase KdsDAdd BLAST328

Proteomic databases

PaxDbiQ8ZLS1
PRIDEiQ8ZLS1

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3315

Chemistry databases

BindingDBiQ8ZLS1

Structurei

3D structure databases

ProteinModelPortaliQ8ZLS1
SMRiQ8ZLS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 184SISPROSITE-ProRule annotationAdd BLAST144
Domaini210 – 268CBS 1PROSITE-ProRule annotationAdd BLAST59
Domaini277 – 328CBS 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 76Substrate bindingBy similarity2
Regioni114 – 123Substrate bindingBy similarity10
Regioni148 – 150Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the SIS family. GutQ/KpsF subfamily.Curated

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4105C2X Bacteria
COG0517 LUCA
COG0794 LUCA
HOGENOMiHOG000264729
KOiK06041
OMAiFMHAADA
PhylomeDBiQ8ZLS1

Family and domain databases

CDDicd05014 SIS_Kpsf, 1 hit
InterProiView protein in InterPro
IPR000644 CBS_dom
IPR004800 KdsD/KpsF-type
IPR001347 SIS
IPR035474 SIS_Kpsf
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF01380 SIS, 1 hit
PIRSFiPIRSF004692 KdsD_KpsF, 1 hit
TIGRFAMsiTIGR00393 kpsF, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZLS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHLALQPGF DFQQAGKEVL EIEREGLAEL DQYINQHFTL ACEKMFNCTG
60 70 80 90 100
KVVVMGMGKS GHIGRKMAAT FASTGTSSFF VHPGEAAHGD LGMVTPQDVV
110 120 130 140 150
IAISNSGESS EIAALIPVLK RLHVPLICIT GRPESSMARA ADVHLCVKVP
160 170 180 190 200
KEACPLGLAP TSSTTATLVM GDALAVALLK ARGFTAEDFA LSHPGGALGR
210 220 230 240 250
KLLLRVSDIM HTGDEIPHVN KHATLRDALL EITRKNLGMT VICDESMKID
260 270 280 290 300
GIFTDGDLRR VFDMGGDMRQ LGIAEVMTPG GIRVRPGILA VDALNLMQSR
310 320
HITSVLVADG DQLLGVLHMH DLLRAGVV
Length:328
Mass (Da):35,000
Last modified:March 1, 2002 - v1
Checksum:iCF9E3B2F86858F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22184.1
RefSeqiNP_462225.1, NC_003197.2
WP_000018617.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22184; AAL22184; STM3315
GeneIDi1254838
KEGGistm:STM3315
PATRICifig|99287.12.peg.3516

Similar proteinsi

Entry informationi

Entry nameiKDSD_SALTY
AccessioniPrimary (citable) accession number: Q8ZLS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again