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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.19 4559
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:YPO0929, y3313, YP_3513
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499911 – 659Biosynthetic arginine decarboxylaseAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8ZHG8
PRIDEiQ8ZHG8

Interactioni

Protein-protein interaction databases

IntActiQ8ZHG8, 7 interactors
STRINGi187410.y3313

Structurei

3D structure databases

ProteinModelPortaliQ8ZHG8
SMRiQ8ZHG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 318Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDNLISRP LTAGAHVSLR SMQEVAMNDR NASKMLSTYN VAYWGGNYYD
60 70 80 90 100
VNELGHISVC PDPDIREARV DLAQLVKKMQ LEQGQRLPAL FCFPQILQHR
110 120 130 140 150
LRSINAAFKR ARESFGYEGG YFLVYPIKVN QHRRVIESLV NSGEPLGLEA
160 170 180 190 200
GSKAEMMAVL AHAGMTRSVI VCNGYKDREY IRLALIGEKL GHKVYLVIEK
210 220 230 240 250
MSEIKMVLEE AERLNVVPRL GVRARLASQG SGKWQASGGE KSKFGLSATQ
260 270 280 290 300
VLQLVDMLRE ANSLESLQLL HFHLGSQLSN IRDISTGVRE SARFYVELHK
310 320 330 340 350
LGVNIQCFDV GGGLGVDYEG TRSQSDCSVN YGLNEYANNV IWGIGDACNE
360 370 380 390 400
HGLPHPTVIT ESGRAVTAHH TVLVSNVIGV ERNEFCEPQP PEAGAPRALE
410 420 430 440 450
SLWDTWQEMQ EPENRRSLRE WLHDSQMDLH DVHTQYAHGM LDLTHRAWAE
460 470 480 490 500
QLYLSICNEI QKQLDPSNRA HRPIIDELQE RMADKLYVNF SLFQSMPDAW
510 520 530 540 550
GIDQLFPVLP LEGLDKPPER RAVLLDITCD SDGTIDHYID GDGVATTMPM
560 570 580 590 600
PPYDPENPPL LGFFMVGAYQ EILGNMHNLF GDTAAVDVYV FPDGTVEVEQ
610 620 630 640 650
TDEGDTVADM LEYVQLNPEK LLEHFRGQVK ETDLDTELQA QFLEEFEAGL

YGYTYLEDE
Length:659
Mass (Da):74,104
Last modified:March 1, 2002 - v1
Checksum:iAD2795F60745B686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL19596.1
AE009952 Genomic DNA Translation: AAM86863.1
AE017042 Genomic DNA Translation: AAS63667.1
PIRiAB0114
RefSeqiWP_002209969.1, NZ_PVMU01000027.1
YP_002345977.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM86863; AAM86863; y3313
AAS63667; AAS63667; YP_3513
GeneIDi1173766
KEGGiype:YPO0929
ypj:CH55_3613
ypk:y3313
ypl:CH46_4218
ypm:YP_3513
ypv:BZ15_2646
ypw:CH59_937
PATRICifig|214092.21.peg.1206

Similar proteinsi

Entry informationi

Entry nameiSPEA_YERPE
AccessioniPrimary (citable) accession number: Q8ZHG8
Secondary accession number(s): Q0WIB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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