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UniProtKB - Q8ZH61 (UPPS_YERPE)
Protein
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Gene
uppS
Organism
Yersinia pestis
Status
Functioni
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
UniRule annotationCatalytic activityi
- (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphateUniRule annotationEC:2.5.1.31UniRule annotation
Cofactori
Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 24 | UniRule annotation | 1 | |
Metal bindingi | 24 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 29 | SubstrateUniRule annotation | 1 | |
Binding sitei | 37 | SubstrateUniRule annotation | 1 | |
Binding sitei | 41 | SubstrateUniRule annotation | 1 | |
Active sitei | 72 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 73 | SubstrateUniRule annotation | 1 | |
Binding sitei | 75 | SubstrateUniRule annotation | 1 | |
Binding sitei | 192 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 197 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 211 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- di-trans,poly-cis-decaprenylcistransferase activity Source: GO_Central
- magnesium ion binding Source: GO_Central
- manganese ion binding Source: GO_Central
- polyprenyltransferase activity Source: GO_Central
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- polyprenol biosynthetic process Source: GO_Central
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)Alternative name(s): Ditrans,polycis-undecaprenylcistransferaseUniRule annotation Undecaprenyl diphosphate synthaseUniRule annotation Short name: UDSUniRule annotation Undecaprenyl pyrophosphate synthaseUniRule annotation Short name: UPP synthaseUniRule annotation |
Gene namesi | Name:uppSUniRule annotation Ordered Locus Names:YPO1049, y3130, YP_2801 |
Organismi | Yersinia pestis |
Taxonomic identifieri | 632 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123723 | 1 – 252 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)Add BLAST | 252 |
Proteomic databases
PaxDbi | Q8ZH61 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 214092.YPO1049 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 28 | Substrate bindingUniRule annotation | 4 | |
Regioni | 69 – 71 | Substrate bindingUniRule annotation | 3 | |
Regioni | 198 – 200 | Substrate bindingUniRule annotation | 3 |
Sequence similaritiesi
Belongs to the UPP synthase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0020, Bacteria |
HOGENOMi | CLU_038505_1_1_6 |
Family and domain databases
CDDi | cd00475, Cis_IPPS, 1 hit |
Gene3Di | 3.40.1180.10, 1 hit |
HAMAPi | MF_01139, ISPT, 1 hit |
InterProi | View protein in InterPro IPR001441, UPP_synth-like IPR018520, UPP_synth-like_CS IPR036424, UPP_synth-like_sf |
PANTHERi | PTHR10291, PTHR10291, 1 hit |
Pfami | View protein in Pfam PF01255, Prenyltransf, 1 hit |
SUPFAMi | SSF64005, SSF64005, 1 hit |
TIGRFAMsi | TIGR00055, uppS, 1 hit |
PROSITEi | View protein in PROSITE PS01066, UPP_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8ZH61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPVKEDRAN LSPRSPRHVA IIMDGNGRWA KNKGKLRVFG HKAGVKSVRR
60 70 80 90 100
AVSFAAKHNL DALTLYAFSS ENWNRPDQEV TALMELFVRA LDSEVKSLHK
110 120 130 140 150
HNVRLSIIGD ISRFSGRLQE RIRRSEKLTA NNDGLKLNIA ANYGGRWDII
160 170 180 190 200
QGVRHLAEQV QKGELQPTDI SEESLNSYIC LHEQSQVDLV IRTGGEHRIS
210 220 230 240 250
NFLLWQIAYA ELYFTDVLWP DFDENVFEGA LNAFAQRERR FGGTTPIDAT
AS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590842 Genomic DNA Translation: CAL19714.1 AE009952 Genomic DNA Translation: AAM86680.1 AE017042 Genomic DNA Translation: AAS62985.1 |
PIRi | AH0128 |
RefSeqi | WP_002212136.1, NZ_WUCM01000044.1 YP_002346092.1, NC_003143.1 |
Genome annotation databases
EnsemblBacteriai | AAM86680; AAM86680; y3130 AAS62985; AAS62985; YP_2801 |
GeneIDi | 66844573 |
KEGGi | ype:YPO1049 ypk:y3130 ypm:YP_2801 |
PATRICi | fig|214092.21.peg.1337 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590842 Genomic DNA Translation: CAL19714.1 AE009952 Genomic DNA Translation: AAM86680.1 AE017042 Genomic DNA Translation: AAS62985.1 |
PIRi | AH0128 |
RefSeqi | WP_002212136.1, NZ_WUCM01000044.1 YP_002346092.1, NC_003143.1 |
3D structure databases
SMRi | Q8ZH61 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 214092.YPO1049 |
Proteomic databases
PaxDbi | Q8ZH61 |
Protocols and materials databases
DNASUi | 1148077 |
Genome annotation databases
EnsemblBacteriai | AAM86680; AAM86680; y3130 AAS62985; AAS62985; YP_2801 |
GeneIDi | 66844573 |
KEGGi | ype:YPO1049 ypk:y3130 ypm:YP_2801 |
PATRICi | fig|214092.21.peg.1337 |
Phylogenomic databases
eggNOGi | COG0020, Bacteria |
HOGENOMi | CLU_038505_1_1_6 |
Family and domain databases
CDDi | cd00475, Cis_IPPS, 1 hit |
Gene3Di | 3.40.1180.10, 1 hit |
HAMAPi | MF_01139, ISPT, 1 hit |
InterProi | View protein in InterPro IPR001441, UPP_synth-like IPR018520, UPP_synth-like_CS IPR036424, UPP_synth-like_sf |
PANTHERi | PTHR10291, PTHR10291, 1 hit |
Pfami | View protein in Pfam PF01255, Prenyltransf, 1 hit |
SUPFAMi | SSF64005, SSF64005, 1 hit |
TIGRFAMsi | TIGR00055, uppS, 1 hit |
PROSITEi | View protein in PROSITE PS01066, UPP_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UPPS_YERPE | |
Accessioni | Q8ZH61Primary (citable) accession number: Q8ZH61 Secondary accession number(s): Q0WHZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families