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Protein

Protease HtpX

Gene

htpX

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi139Zinc; catalyticUniRule annotation1
Active sitei140UniRule annotation1
Metal bindingi143Zinc; catalyticUniRule annotation1
Metal bindingi222Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpXUniRule annotation (EC:3.4.24.-UniRule annotation)
Alternative name(s):
Heat shock protein HtpXUniRule annotation
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:YPO1706, y1868, YP_1731
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389111 – 293Protease HtpXAdd BLAST293

Proteomic databases

PaxDbiQ8ZFJ7

Interactioni

Protein-protein interaction databases

IntActiQ8ZFJ7, 1 interactor
STRINGi187410.y1868

Structurei

3D structure databases

ProteinModelPortaliQ8ZFJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D0M Bacteria
COG0501 LUCA
HOGENOMiHOG000227302
KOiK03799
OMAiAVCCTEG

Family and domain databases

HAMAPiMF_00188 Pept_M48_protease_HtpX, 1 hit
InterProiView protein in InterPro
IPR022919 Pept_M48_protease_HtpX
IPR001915 Peptidase_M48
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZFJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRIALFLLT NLAVMLVFGL VLSLTGIQSS SVQGLMIMAG LFGFGGAFVS
60 70 80 90 100
LLMSKWMALR SVGGEVIERP RNETEYWLLE TVRRQSQQVG IAMPQVAIYQ
110 120 130 140 150
APDINAFATG ARRDASLVAV STGLLQNMSR DEAEAVIAHE ISHVANGDMV
160 170 180 190 200
TMTLIQGVVN TFVIFISRLI AQIAAGFLSG DRDGESNSPG NPMVYFAVSM
210 220 230 240 250
VLELVFGILA SIITMWFSRH REFHADAGSA KLVGREKMIA ALQRLKTSYE
260 270 280 290
PQEAGSMMAF CINGKSKTFS ELFMSHPPLD KRIEALRSGQ YLK
Length:293
Mass (Da):32,064
Last modified:March 1, 2002 - v1
Checksum:i24B1038E0153D7DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL20349.1
AE009952 Genomic DNA Translation: AAM85435.1
AE017042 Genomic DNA Translation: AAS61959.1
PIRiAB0208
RefSeqiWP_002210847.1, NZ_PDBR01000042.1
YP_002346709.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85435; AAM85435; y1868
AAS61959; AAS61959; YP_1731
GeneIDi1174543
KEGGiype:YPO1706
ypk:y1868
ypm:YP_1731
PATRICifig|1028802.3.peg.1934

Similar proteinsi

Entry informationi

Entry nameiHTPX_YERPE
AccessioniPrimary (citable) accession number: Q8ZFJ7
Secondary accession number(s): Q0WG79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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