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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi58MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:YPO2929, y1301, YP_2526
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001757331 – 126Holo-[acyl-carrier-protein] synthaseAdd BLAST126

Proteomic databases

PaxDbiQ8ZCP5

Interactioni

Protein-protein interaction databases

STRINGi187410.y1301

Structurei

3D structure databases

ProteinModelPortaliQ8ZCP5
SMRiQ8ZCP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KJV Bacteria
COG0736 LUCA
HOGENOMiHOG000014316
KOiK00997
OMAiDERHYAV

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZCP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAILGLGTDI VEISRIQAVV ERTGERLARR ILSPSEWQHY QQHQQPVRFL
60 70 80 90 100
AKRFAVKEAA AKAFGTGIRN GLAFNQFEVV NDALGKPTLR LHSRAAELAV
110 120
ELGVKSLHVT LADERRYACA TVIIES
Length:126
Mass (Da):13,992
Last modified:March 27, 2002 - v1
Checksum:iA5EA7AD1E9B8CCE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21537.1
AE009952 Genomic DNA Translation: AAM84875.1
AE017042 Genomic DNA Translation: AAS62724.1
PIRiAF0356
RefSeqiWP_002211568.1, NZ_PVMU01000006.1
YP_002347859.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84875; AAM84875; y1301
AAS62724; AAS62724; YP_2526
GeneIDi1175750
KEGGiype:YPO2929
ypk:y1301
ypm:YP_2526
PATRICifig|1028802.3.peg.431

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21537.1
AE009952 Genomic DNA Translation: AAM84875.1
AE017042 Genomic DNA Translation: AAS62724.1
PIRiAF0356
RefSeqiWP_002211568.1, NZ_PVMU01000006.1
YP_002347859.1, NC_003143.1

3D structure databases

ProteinModelPortaliQ8ZCP5
SMRiQ8ZCP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y1301

Proteomic databases

PaxDbiQ8ZCP5

Protocols and materials databases

DNASUi1146248
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84875; AAM84875; y1301
AAS62724; AAS62724; YP_2526
GeneIDi1175750
KEGGiype:YPO2929
ypk:y1301
ypm:YP_2526
PATRICifig|1028802.3.peg.431

Phylogenomic databases

eggNOGiENOG4105KJV Bacteria
COG0736 LUCA
HOGENOMiHOG000014316
KOiK00997
OMAiDERHYAV

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACPS_YERPE
AccessioniPrimary (citable) accession number: Q8ZCP5
Secondary accession number(s): Q0WCX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 10, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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