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Entry version 107 (26 Feb 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Acyl-coenzyme A dehydrogenase

Gene

fadE

Organism
Salmonella typhi
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for the utilization of medium- and long-chain fatty acids as sole carbon sources for growth. Is needed for bacterial survival during carbone-source starvation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei497Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001048035:AC754_RS19405-MONOMER
GCF_001048375:AC768_RS06345-MONOMER
GCF_001079465:ADV44_RS17180-MONOMER
GCF_001088345:AEZ18_RS07725-MONOMER
GCF_001095585:AD238_RS06725-MONOMER
GCF_001106745:AE121_RS17200-MONOMER
GCF_001119245:AE140_RS18250-MONOMER
GCF_001121865:AE338_RS07305-MONOMER
GCF_001127485:AE735_RS18520-MONOMER
GCF_001135805:AEG73_RS06565-MONOMER
GCF_001148125:AEN24_RS15485-MONOMER
GCF_001148305:AEN67_RS20020-MONOMER
GCF_001157245:AER93_RS06575-MONOMER
GCF_001163025:AFA50_RS06340-MONOMER
GCF_001165785:AFA97_RS18330-MONOMER
GCF_001240865:ALC23_RS07615-MONOMER
GCF_001356455:AQJ76_RS06345-MONOMER
GCF_001357935:AQL34_RS06790-MONOMER
GCF_001359015:AQL50_RS06485-MONOMER
GCF_001360555:AQK88_RS06345-MONOMER
GCF_001361075:AQM75_RS17930-MONOMER
GCF_001362095:AQO19_RS18705-MONOMER
GCF_001362135:AQN73_RS07890-MONOMER
GCF_001362175:AQN68_RS06345-MONOMER
GCF_001362195:AQN87_RS19090-MONOMER
GCF_001362335:AQN99_RS20010-MONOMER
GCF_001364695:AQQ97_RS07100-MONOMER
GCF_900185485:CDZ80_RS17585-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00659

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A dehydrogenaseBy similarity (EC:1.3.8.7By similarity, EC:1.3.8.8By similarity)
Short name:
ACDHBy similarity
Short name:
Acyl-CoA dehydrogenaseBy similarity
Alternative name(s):
Medium-/long-chain fatty acyl-CoA dehydrogenaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fadE
Ordered Locus Names:STY0354, t2541
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90370 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002670 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002012021 – 814Acyl-coenzyme A dehydrogenaseAdd BLAST814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
220341.16501595

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107QPN Bacteria
COG1960 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012192_0_0_6

KEGG Orthology (KO)

More...
KOi
K06445

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR015396 DUF1974

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
PF09317 DUF1974, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8Z937-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMILSIIATV VLLGALFYHR VSLFLSSLIL LAWTAALGVA GLWSIWLLVP
60 70 80 90 100
LAIILVPFNL TPMRKSMISA PVFRGFRKVM PPMSRTEKEA IDAGTTWWEG
110 120 130 140 150
DLFQGKPDWK KLHNYPQPQL TAEEQAFLDG PVEEACRMAN DFQITHELAD
160 170 180 190 200
LPPELWAYLK EHRFFAMIIK KEYGGLEFSA YVQSRVLQKL SGVSGILAIT
210 220 230 240 250
VGVPNSLGPG ELLQHYGTEE QKNHYLPRLA RGQEIPCFAL TSPEAGSDAG
260 270 280 290 300
AIPDTGVVCM GEWQGQQVLG MRLTWNKRYI TLAPIATVLG LAFKLSDPDR
310 320 330 340 350
LLGGEEELGI TCALIPTSTP GVEIGRRHFP LNVPFQNGPT RGNDIFVPID
360 370 380 390 400
YIIGGPKMAG QGWRMLVECL SVGRGITLPS NSTGGVKSVA LATGAYAHIR
410 420 430 440 450
RQFKISIGKM EGIEEPLARI AGNAYVMDAA ASLITYGIML GEKPAVLSAI
460 470 480 490 500
VKYHCTHRGQ QSIIDAMDIT GGKGIMLGES NFLARAYQGA PIAITVEGAN
510 520 530 540 550
ILTRSMMIFG QGAIRCHPYV LEEMAAAQNN DVNAFDKLLF KHIGHVGSNT
560 570 580 590 600
VRSFWLGLTR GLTSHTPTGD ATKRYYQHLN RLSANLALLS DVSMAVLGGS
610 620 630 640 650
LKRRERISTR LGDVLSQLYL ASAVLKRYDD EGRHEADLPL VHWGVQDALY
660 670 680 690 700
RAEQAMDDLL QNFPNRVVAG LLTAMIFPTG RHYLAPSDKL DHAVAKILQV
710 720 730 740 750
PNATRSRIGR GQYLTPAEHN PVGLLEEALR DVIAADPIHQ RICKELGKNL
760 770 780 790 800
PFTRLDELAR NALAKGLIDK DEAAILAKAE ESRLRSINVD DFEPEALATK
810
PVKLPEKVRK VEAA
Length:814
Mass (Da):89,274
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i425C6195436B2E07
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08779.1
AE014613 Genomic DNA Translation: AAO70125.1

NCBI Reference Sequences

More...
RefSeqi
NP_454921.1, NC_003198.1
WP_000973055.1, NZ_UFRG01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO70125; AAO70125; t2541
CAD08779; CAD08779; CAD08779

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1246836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stt:t2541
sty:STY0354

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|220341.7.peg.348

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08779.1
AE014613 Genomic DNA Translation: AAO70125.1
RefSeqiNP_454921.1, NC_003198.1
WP_000973055.1, NZ_UFRG01000003.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi220341.16501595

Genome annotation databases

EnsemblBacteriaiAAO70125; AAO70125; t2541
CAD08779; CAD08779; CAD08779
GeneIDi1246836
KEGGistt:t2541
sty:STY0354
PATRICifig|220341.7.peg.348

Phylogenomic databases

eggNOGiENOG4107QPN Bacteria
COG1960 LUCA
HOGENOMiCLU_012192_0_0_6
KOiK06445

Enzyme and pathway databases

UniPathwayiUPA00659
BioCyciGCF_001048035:AC754_RS19405-MONOMER
GCF_001048375:AC768_RS06345-MONOMER
GCF_001079465:ADV44_RS17180-MONOMER
GCF_001088345:AEZ18_RS07725-MONOMER
GCF_001095585:AD238_RS06725-MONOMER
GCF_001106745:AE121_RS17200-MONOMER
GCF_001119245:AE140_RS18250-MONOMER
GCF_001121865:AE338_RS07305-MONOMER
GCF_001127485:AE735_RS18520-MONOMER
GCF_001135805:AEG73_RS06565-MONOMER
GCF_001148125:AEN24_RS15485-MONOMER
GCF_001148305:AEN67_RS20020-MONOMER
GCF_001157245:AER93_RS06575-MONOMER
GCF_001163025:AFA50_RS06340-MONOMER
GCF_001165785:AFA97_RS18330-MONOMER
GCF_001240865:ALC23_RS07615-MONOMER
GCF_001356455:AQJ76_RS06345-MONOMER
GCF_001357935:AQL34_RS06790-MONOMER
GCF_001359015:AQL50_RS06485-MONOMER
GCF_001360555:AQK88_RS06345-MONOMER
GCF_001361075:AQM75_RS17930-MONOMER
GCF_001362095:AQO19_RS18705-MONOMER
GCF_001362135:AQN73_RS07890-MONOMER
GCF_001362175:AQN68_RS06345-MONOMER
GCF_001362195:AQN87_RS19090-MONOMER
GCF_001362335:AQN99_RS20010-MONOMER
GCF_001364695:AQQ97_RS07100-MONOMER
GCF_900185485:CDZ80_RS17585-MONOMER

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR015396 DUF1974
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
PF09317 DUF1974, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFADE_SALTI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8Z937
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: February 26, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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