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Entry version 116 (05 Jun 2019)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Putative pertussis-like toxin subunit

Gene

STY1891

Organism
Salmonella typhi
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001048035:AC754_RS11650-MONOMER
GCF_001048375:AC768_RS14120-MONOMER
GCF_001079465:ADV44_RS09415-MONOMER
GCF_001088345:AEZ18_RS15530-MONOMER
GCF_001095585:AD238_RS14495-MONOMER
GCF_001104165:AE704_RS14120-MONOMER
GCF_001104885:AEZ38_RS14845-MONOMER
GCF_001106745:AE121_RS09430-MONOMER
GCF_001118185:AE086_RS10555-MONOMER
GCF_001119245:AE140_RS10485-MONOMER
GCF_001121865:AE338_RS15080-MONOMER
GCF_001127485:AE735_RS10480-MONOMER
GCF_001135805:AEG73_RS14340-MONOMER
GCF_001148125:AEN24_RS07695-MONOMER
GCF_001148305:AEN67_RS12245-MONOMER
GCF_001157245:AER93_RS14360-MONOMER
GCF_001163025:AFA50_RS14395-MONOMER
GCF_001165785:AFA97_RS10555-MONOMER
GCF_001240865:ALC23_RS15380-MONOMER
GCF_001356455:AQJ76_RS14120-MONOMER
GCF_001357935:AQL34_RS23790-MONOMER
GCF_001359015:AQL50_RS23600-MONOMER
GCF_001360555:AQK88_RS14120-MONOMER
GCF_001361075:AQM75_RS10160-MONOMER
GCF_001362095:AQO19_RS10915-MONOMER
GCF_001362135:AQN73_RS15470-MONOMER
GCF_001362175:AQN68_RS14120-MONOMER
GCF_001362195:AQN87_RS02120-MONOMER
GCF_001362335:AQN99_RS12230-MONOMER
GCF_001364695:AQQ97_RS24215-MONOMER
GCF_900185485:CDZ80_RS09810-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative pertussis-like toxin subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:STY1891Imported, t1107Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90370 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002670 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501410766024 – 137Sequence analysisAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 70Combined sources
Disulfide bondi128 ↔ 133Combined sources

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
STY1890Q8Z6A44EBI-16063983,EBI-16064001

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60314N

Protein interaction database and analysis system

More...
IntActi
Q8Z6A3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
220341.16502958

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8Z6A3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 133Pertussis_S2S3InterPro annotationAdd BLAST100

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105W77 Bacteria
ENOG41122WM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290512

KEGG Orthology (KO)

More...
KOi
K19298

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008992 Enterotoxin
IPR020063 ToxinB_su2/3_C_BORPE

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02918 Pertussis_S2S3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50203 SSF50203, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8Z6A3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMSKYVPVY TLLILIYSFN ASAEWTGDNT NAYYSDEVIS ELHVGQIDTS
60 70 80 90 100
PYFCIKTVKA NGSGTPVVAC AVSKQSIWAP SFKELLDQAR YFYSTGQSVR
110 120 130
IHVQKNIWTY PLFVNTFSAN ALVGLSSCSA TQCFGPK
Length:137
Mass (Da):15,223
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C7531F1DFFD99D9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014613 Genomic DNA Translation: AAO68770.1
AL513382 Genomic DNA Translation: CAD02124.1

NCBI Reference Sequences

More...
RefSeqi
NP_456279.1, NC_003198.1
WP_000281950.1, NZ_UFRG01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO68770; AAO68770; t1107
CAD02124; CAD02124; CAD02124
CGW70285; CGW70285; ERS248933_04664

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1248253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stt:t1107
sty:STY1891

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|220341.7.peg.1905

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014613 Genomic DNA Translation: AAO68770.1
AL513382 Genomic DNA Translation: CAD02124.1
RefSeqiNP_456279.1, NC_003198.1
WP_000281950.1, NZ_UFRG01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K6LX-ray2.39A/B/C/D/E24-137[»]
4RHRX-ray2.08A/B/C/D/E24-137[»]
4RHSX-ray1.92A/B/C/D/E24-137[»]
5WHTX-ray1.93A/B/C/D/E1-137[»]
SMRiQ8Z6A3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60314N
IntActiQ8Z6A3, 2 interactors
STRINGi220341.16502958

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO68770; AAO68770; t1107
CAD02124; CAD02124; CAD02124
CGW70285; CGW70285; ERS248933_04664
GeneIDi1248253
KEGGistt:t1107
sty:STY1891
PATRICifig|220341.7.peg.1905

Phylogenomic databases

eggNOGiENOG4105W77 Bacteria
ENOG41122WM LUCA
HOGENOMiHOG000290512
KOiK19298

Enzyme and pathway databases

BioCyciGCF_001048035:AC754_RS11650-MONOMER
GCF_001048375:AC768_RS14120-MONOMER
GCF_001079465:ADV44_RS09415-MONOMER
GCF_001088345:AEZ18_RS15530-MONOMER
GCF_001095585:AD238_RS14495-MONOMER
GCF_001104165:AE704_RS14120-MONOMER
GCF_001104885:AEZ38_RS14845-MONOMER
GCF_001106745:AE121_RS09430-MONOMER
GCF_001118185:AE086_RS10555-MONOMER
GCF_001119245:AE140_RS10485-MONOMER
GCF_001121865:AE338_RS15080-MONOMER
GCF_001127485:AE735_RS10480-MONOMER
GCF_001135805:AEG73_RS14340-MONOMER
GCF_001148125:AEN24_RS07695-MONOMER
GCF_001148305:AEN67_RS12245-MONOMER
GCF_001157245:AER93_RS14360-MONOMER
GCF_001163025:AFA50_RS14395-MONOMER
GCF_001165785:AFA97_RS10555-MONOMER
GCF_001240865:ALC23_RS15380-MONOMER
GCF_001356455:AQJ76_RS14120-MONOMER
GCF_001357935:AQL34_RS23790-MONOMER
GCF_001359015:AQL50_RS23600-MONOMER
GCF_001360555:AQK88_RS14120-MONOMER
GCF_001361075:AQM75_RS10160-MONOMER
GCF_001362095:AQO19_RS10915-MONOMER
GCF_001362135:AQN73_RS15470-MONOMER
GCF_001362175:AQN68_RS14120-MONOMER
GCF_001362195:AQN87_RS02120-MONOMER
GCF_001362335:AQN99_RS12230-MONOMER
GCF_001364695:AQQ97_RS24215-MONOMER
GCF_900185485:CDZ80_RS09810-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR020063 ToxinB_su2/3_C_BORPE
PfamiView protein in Pfam
PF02918 Pertussis_S2S3, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8Z6A3_SALTI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8Z6A3
Secondary accession number(s): A0A0C9FGG7, Q7CAE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 5, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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