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Entry version 136 (26 Feb 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Transcriptional regulatory protein ZraR

Gene

zraR

Organism
Salmonella typhi
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi169 – 176ATPPROSITE-ProRule annotation8
Nucleotide bindingi232 – 241ATPPROSITE-ProRule annotation10
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi421 – 440H-T-H motifBy similarityAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001048035:AC754_RS23535-MONOMER
GCF_001048375:AC768_RS23735-MONOMER
GCF_001079465:ADV44_RS23995-MONOMER
GCF_001088345:AEZ18_RS00770-MONOMER
GCF_001095585:AD238_RS23135-MONOMER
GCF_001104165:AE704_RS23585-MONOMER
GCF_001104885:AEZ38_RS24330-MONOMER
GCF_001106745:AE121_RS24020-MONOMER
GCF_001118185:AE086_RS24390-MONOMER
GCF_001119245:AE140_RS24285-MONOMER
GCF_001121865:AE338_RS23695-MONOMER
GCF_001127485:AE735_RS23800-MONOMER
GCF_001135805:AEG73_RS02445-MONOMER
GCF_001148125:AEN24_RS23065-MONOMER
GCF_001148305:AEN67_RS00765-MONOMER
GCF_001157245:AER93_RS24645-MONOMER
GCF_001163025:AFA50_RS24085-MONOMER
GCF_001165785:AFA97_RS22860-MONOMER
GCF_001240865:ALC23_RS00790-MONOMER
GCF_001356455:AQJ76_RS24580-MONOMER
GCF_001357935:AQL34_RS14365-MONOMER
GCF_001359015:AQL50_RS13300-MONOMER
GCF_001360555:AQK88_RS24380-MONOMER
GCF_001361075:AQM75_RS24980-MONOMER
GCF_001362095:AQO19_RS23920-MONOMER
GCF_001362135:AQN73_RS23730-MONOMER
GCF_001362175:AQN68_RS24580-MONOMER
GCF_001362195:AQN87_RS11515-MONOMER
GCF_001362335:AQN99_RS00015-MONOMER
GCF_001364695:AQQ97_RS13925-MONOMER
GCF_900185485:CDZ80_RS24610-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional regulatory protein ZraR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zraR
Synonyms:hydG
Ordered Locus Names:STY3711, t3457
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90370 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002670 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000812821 – 441Transcriptional regulatory protein ZraRAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei564-aspartylphosphatePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ZraS.By similarity

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
220341.16504587

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8Z333

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini141 – 370Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C1W Bacteria
COG2204 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_0_6_6

KEGG Orthology (KO)

More...
KOi
K07713

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00156 REC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR001789 Sig_transdc_resp-reg_receiver
IPR002078 Sigma_54_int
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR025944 Sigma_54_int_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02954 HTH_8, 1 hit
PF00072 Response_reg, 1 hit
PF00158 Sigma54_activat, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01590 HTHFIS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00448 REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit
PS00676 SIGMA54_INTERACT_2, 1 hit
PS00688 SIGMA54_INTERACT_3, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8Z333-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRGKIDILV VDDDVSHCTI LQALLRGWGY NVALAYSGHD ALAQVREKVF
60 70 80 90 100
DLVLCDVRMA EMDGIATLKE IKALNPAIPI LIMTAFSSVE TAVEALKAGA
110 120 130 140 150
LDYLIKPLDF DRLQETLEKA LAHTRETGAE LPSASAAQFG MIGSSPAMQH
160 170 180 190 200
LLNEIAMVAP SDATVLIHGD SGTGKELVAR ALHACSARSD KPLVTLNCAA
210 220 230 240 250
LNESLLESEL FGHEKGAFTG ADKRREGRFV EADGGTLFLD EIGDISPLMQ
260 270 280 290 300
VRLLRAIQER EVQRVGSNQT ISVDVWLIAA THRDLAEEVS AGRFRQDLYY
310 320 330 340 350
RLNVVAIEMP SLRQRREDIP LLADHFLRRF AERNRKAVKG FTPQAMDLLI
360 370 380 390 400
HYDWPGNIRE LENAIERAVV LLTGEYISER ELPLAIAATP IKAENSAEIQ
410 420 430 440
PLVDVEKEVI LAALEKTGGN KTEAARQLGI TRKTLLAKLS R
Length:441
Mass (Da):48,499
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA071FB6466113204
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD09470.1
AE014613 Genomic DNA Translation: AAO70973.1

NCBI Reference Sequences

More...
RefSeqi
NP_457900.1, NC_003198.1
WP_000617932.1, NZ_UFRG01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO70973; AAO70973; t3457
CAD09470; CAD09470; CAD09470

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1249967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stt:t3457
sty:STY3711

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|220341.7.peg.3783

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD09470.1
AE014613 Genomic DNA Translation: AAO70973.1
RefSeqiNP_457900.1, NC_003198.1
WP_000617932.1, NZ_UFRG01000003.1

3D structure databases

SMRiQ8Z333
ModBaseiSearch...

Protein-protein interaction databases

STRINGi220341.16504587

Genome annotation databases

EnsemblBacteriaiAAO70973; AAO70973; t3457
CAD09470; CAD09470; CAD09470
GeneIDi1249967
KEGGistt:t3457
sty:STY3711
PATRICifig|220341.7.peg.3783

Phylogenomic databases

eggNOGiENOG4105C1W Bacteria
COG2204 LUCA
HOGENOMiCLU_000445_0_6_6
KOiK07713

Enzyme and pathway databases

BioCyciGCF_001048035:AC754_RS23535-MONOMER
GCF_001048375:AC768_RS23735-MONOMER
GCF_001079465:ADV44_RS23995-MONOMER
GCF_001088345:AEZ18_RS00770-MONOMER
GCF_001095585:AD238_RS23135-MONOMER
GCF_001104165:AE704_RS23585-MONOMER
GCF_001104885:AEZ38_RS24330-MONOMER
GCF_001106745:AE121_RS24020-MONOMER
GCF_001118185:AE086_RS24390-MONOMER
GCF_001119245:AE140_RS24285-MONOMER
GCF_001121865:AE338_RS23695-MONOMER
GCF_001127485:AE735_RS23800-MONOMER
GCF_001135805:AEG73_RS02445-MONOMER
GCF_001148125:AEN24_RS23065-MONOMER
GCF_001148305:AEN67_RS00765-MONOMER
GCF_001157245:AER93_RS24645-MONOMER
GCF_001163025:AFA50_RS24085-MONOMER
GCF_001165785:AFA97_RS22860-MONOMER
GCF_001240865:ALC23_RS00790-MONOMER
GCF_001356455:AQJ76_RS24580-MONOMER
GCF_001357935:AQL34_RS14365-MONOMER
GCF_001359015:AQL50_RS13300-MONOMER
GCF_001360555:AQK88_RS24380-MONOMER
GCF_001361075:AQM75_RS24980-MONOMER
GCF_001362095:AQO19_RS23920-MONOMER
GCF_001362135:AQN73_RS23730-MONOMER
GCF_001362175:AQN68_RS24580-MONOMER
GCF_001362195:AQN87_RS11515-MONOMER
GCF_001362335:AQN99_RS00015-MONOMER
GCF_001364695:AQQ97_RS13925-MONOMER
GCF_900185485:CDZ80_RS24610-MONOMER

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR001789 Sig_transdc_resp-reg_receiver
IPR002078 Sigma_54_int
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR025944 Sigma_54_int_dom_CS
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PF00072 Response_reg, 1 hit
PF00158 Sigma54_activat, 1 hit
PRINTSiPR01590 HTHFIS
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit
PS00676 SIGMA54_INTERACT_2, 1 hit
PS00688 SIGMA54_INTERACT_3, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZRAR_SALTI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8Z333
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2002
Last modified: February 26, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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