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UniProtKB - Q8Z2X8 (LSRB_SALTI)
Protein
Autoinducer 2-binding protein LsrB
Gene
lsrB
Organism
Salmonella typhi
Status
Functioni
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
By similarityNames & Taxonomyi
Protein namesi | Recommended name: Autoinducer 2-binding protein LsrBShort name: AI-2-binding protein LsrB |
Gene namesi | Name:lsrB Ordered Locus Names:STY3793, t3541 |
Organismi | Salmonella typhi |
Taxonomic identifieri | 90370 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
Other locations
- Periplasm Curated
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: InterPro
Other locations
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPathology & Biotechi
Chemistry databases
DrugBanki | DB04346, (2r,4s)-2-Methyl-2,3,3,4-Tetrahydroxytetrahydrofuran |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000351329 | 27 – 340 | Autoinducer 2-binding protein LsrBAdd BLAST | 314 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).
By similarityProtein-protein interaction databases
STRINGi | 220341.16504662 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q8Z2X8 |
SMRi | Q8Z2X8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the bacterial solute-binding protein 2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG1879, Bacteria |
HOGENOMi | CLU_037628_3_0_6 |
OMAi | KQVNNPY |
Family and domain databases
CDDi | cd20003, PBP1_LsrB_Quorum_Sensing, 1 hit |
InterProi | View protein in InterPro IPR030159, LsrB IPR028082, Peripla_BP_I IPR025997, SBP_2_dom |
PANTHERi | PTHR46847:SF4, PTHR46847:SF4, 1 hit |
Pfami | View protein in Pfam PF13407, Peripla_BP_4, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8Z2X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARHSIKMIA LLTAFGLASA VMTVQAAERI AFIPKLVGVG FFTSGGNGAQ
60 70 80 90 100
EAGKALGIDV TYDGPTEPSV SGQVQLVNNF VNQGYDAIIV SAVSPDGLCP
110 120 130 140 150
ALKRAMQRGV KILTWDSDTK PECRSYYINQ GTPKQLGSML VEMAAHQVDK
160 170 180 190 200
EKAKVAFFYS SPTVTDQNQW VKEAKAKISQ EHPGWEIVTT QFGYNDATKS
210 220 230 240 250
LQTAEGIIKA YPDLDAIIAP DANALPAAAQ AAENLKRNNL AIVGFSTPNV
260 270 280 290 300
MRPYVQRGTV KEFGLWDVVQ QGKISVYVAN ALLKNMPMNV GDSLDIPGIG
310 320 330 340
KVTVSPNSEQ GYHYEAKGNG IVLLPERVIF NKDNIDKYDF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014613 Genomic DNA Translation: AAO71048.1 AL513382 Genomic DNA Translation: CAD09546.1 |
RefSeqi | NP_457975.1, NC_003198.1 WP_000090739.1, NZ_WSUR01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAO71048; AAO71048; t3541 |
KEGGi | stt:t3541 sty:STY3793 |
PATRICi | fig|220341.7.peg.3871 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014613 Genomic DNA Translation: AAO71048.1 AL513382 Genomic DNA Translation: CAD09546.1 |
RefSeqi | NP_457975.1, NC_003198.1 WP_000090739.1, NZ_WSUR01000010.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GTA | X-ray | 3.00 | A | 1-340 | [»] | |
AlphaFoldDBi | Q8Z2X8 | |||||
SMRi | Q8Z2X8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 220341.16504662 |
Chemistry databases
DrugBanki | DB04346, (2r,4s)-2-Methyl-2,3,3,4-Tetrahydroxytetrahydrofuran |
Genome annotation databases
EnsemblBacteriai | AAO71048; AAO71048; t3541 |
KEGGi | stt:t3541 sty:STY3793 |
PATRICi | fig|220341.7.peg.3871 |
Phylogenomic databases
eggNOGi | COG1879, Bacteria |
HOGENOMi | CLU_037628_3_0_6 |
OMAi | KQVNNPY |
Family and domain databases
CDDi | cd20003, PBP1_LsrB_Quorum_Sensing, 1 hit |
InterProi | View protein in InterPro IPR030159, LsrB IPR028082, Peripla_BP_I IPR025997, SBP_2_dom |
PANTHERi | PTHR46847:SF4, PTHR46847:SF4, 1 hit |
Pfami | View protein in Pfam PF13407, Peripla_BP_4, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LSRB_SALTI | |
Accessioni | Q8Z2X8Primary (citable) accession number: Q8Z2X8 Secondary accession number(s): Q7C6A1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families