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Entry version 140 (11 Dec 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Thiol:disulfide interchange protein DsbD

Gene

dsbD

Organism
Salmonella typhi
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCytochrome c-type biogenesis, Electron transport, Transport
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001048035:AC754_RS04420-MONOMER
GCF_001048375:AC768_RS21540-MONOMER
GCF_001079465:ADV44_RS02080-MONOMER
GCF_001088345:AEZ18_RS22825-MONOMER
GCF_001095585:AD238_RS21695-MONOMER
GCF_001104165:AE704_RS21450-MONOMER
GCF_001104885:AEZ38_RS22140-MONOMER
GCF_001106745:AE121_RS02080-MONOMER
GCF_001118185:AE086_RS21440-MONOMER
GCF_001119245:AE140_RS21340-MONOMER
GCF_001121865:AE338_RS22285-MONOMER
GCF_001127485:AE735_RS21610-MONOMER
GCF_001135805:AEG73_RS21640-MONOMER
GCF_001148125:AEN24_RS00290-MONOMER
GCF_001148305:AEN67_RS04915-MONOMER
GCF_001157245:AER93_RS21680-MONOMER
GCF_001163025:AFA50_RS21895-MONOMER
GCF_001165785:AFA97_RS21420-MONOMER
GCF_001240865:ALC23_RS22685-MONOMER
GCF_001356455:AQJ76_RS21420-MONOMER
GCF_001357935:AQL34_RS16565-MONOMER
GCF_001359015:AQL50_RS16275-MONOMER
GCF_001360555:AQK88_RS21420-MONOMER
GCF_001361075:AQM75_RS02830-MONOMER
GCF_001362095:AQO19_RS03675-MONOMER
GCF_001362135:AQN73_RS04785-MONOMER
GCF_001362175:AQN68_RS21420-MONOMER
GCF_001362195:AQN87_RS09330-MONOMER
GCF_001362335:AQN99_RS04900-MONOMER
GCF_001364695:AQQ97_RS16885-MONOMER
GCF_900185485:CDZ80_RS02455-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)
Alternative name(s):
Protein-disulfide reductaseUniRule annotation
Short name:
Disulfide reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dsbDUniRule annotation
Ordered Locus Names:STY4682, t4374
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90370 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002670 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei170 – 192HelicalUniRule annotationAdd BLAST23
Transmembranei212 – 234HelicalUniRule annotationAdd BLAST23
Transmembranei246 – 268HelicalUniRule annotationAdd BLAST23
Transmembranei297 – 319HelicalUniRule annotationAdd BLAST23
Transmembranei326 – 348HelicalUniRule annotationAdd BLAST23
Transmembranei358 – 380HelicalUniRule annotationAdd BLAST23
Transmembranei387 – 409HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19UniRule annotationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000738520 – 567Thiol:disulfide interchange protein DsbDAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi122 ↔ 128Redox-activeUniRule annotation
Disulfide bondi185 ↔ 307Redox-activeUniRule annotation
Disulfide bondi482 ↔ 485Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bond

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
220341.16505452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8Z1A8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini435 – 567ThioredoxinUniRule annotationAdd BLAST133

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thioredoxin family. DsbD subfamily.UniRule annotation

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CSG Bacteria
COG4232 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000254981

KEGG Orthology (KO)

More...
KOi
K04084

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02953 DsbDgamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1250, 1 hit
3.40.30.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00399 DbsD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003834 Cyt_c_assmbl_TM_dom
IPR035671 DsbD_gamma
IPR028250 DsbDN
IPR036929 DsbDN_sf
IPR022910 Thiol_diS_interchange_DbsD
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

The PANTHER Classification System

More...
PANTHERi
PTHR32234:SF0 PTHR32234:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11412 DsbC, 1 hit
PF02683 DsbD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit
SSF74863 SSF74863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Z1A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRIFTLIL LLCSTSAFAG LFDAPGRSQF VPADRAFVFD FQQNQHDLTL
60 70 80 90 100
SWQVKEGYYL YRKQISITPT KADIAAVQLP AGVWHEDEFY GKSEIYRKRL
110 120 130 140 150
NVPVTVNQAA AGATLTITYQ GCADAGFCYP PETKTVPLSE VAAAIDATPT
160 170 180 190 200
PAVTQTGETS KPAAQLPFSA LWALLIGIGI AFTPCVLPMY PLISGIVLGG
210 220 230 240 250
RQRLSTGRAL LLAFIYVQGM ALTYTALGLV VAAAGLQFQA ALQHPYVLIG
260 270 280 290 300
LAIVFTLLAL SMFGLFTLQL PSSLQTRLTL MSNRQQGGSP GGVFVMGAIA
310 320 330 340 350
GLICSPCTTA PLSAILLYIA QSGNMWLGGG TLYLYALGMG LPLMLVTVFG
360 370 380 390 400
NRLLPKSGPW MAHVKTAFGF VILALPVFLL ERIIGEAWGL RLWSLLGVAF
410 420 430 440 450
FGWAFITSLQ ARRAWMRIVQ IILLAAALIS VRPLQDWAFG SPSAQAPAHL
460 470 480 490 500
NFTAISTVDE LNQALAQAKG KPVMLDFYAD WCVACKEFEK YTFSDPRVQQ
510 520 530 540 550
VLGDTVLLQA NVTANNAQDV ALLKHLQVLG LPTILFFDAQ GQEQPQARVT
560
GFMDAATFSA HLHDRQP
Length:567
Mass (Da):61,356
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF995E0F1AF9F7C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD06802.1
AE014613 Genomic DNA Translation: AAO71825.1

NCBI Reference Sequences

More...
RefSeqi
NP_458761.1, NC_003198.1
WP_000068881.1, NZ_UFRG01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO71825; AAO71825; t4374
CAD06802; CAD06802; CAD06802

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1250883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stt:t4374
sty:STY4682

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|220341.7.peg.4782

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD06802.1
AE014613 Genomic DNA Translation: AAO71825.1
RefSeqiNP_458761.1, NC_003198.1
WP_000068881.1, NZ_UFRG01000003.1

3D structure databases

SMRiQ8Z1A8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi220341.16505452

Genome annotation databases

EnsemblBacteriaiAAO71825; AAO71825; t4374
CAD06802; CAD06802; CAD06802
GeneIDi1250883
KEGGistt:t4374
sty:STY4682
PATRICifig|220341.7.peg.4782

Phylogenomic databases

eggNOGiENOG4105CSG Bacteria
COG4232 LUCA
HOGENOMiHOG000254981
KOiK04084

Enzyme and pathway databases

BioCyciGCF_001048035:AC754_RS04420-MONOMER
GCF_001048375:AC768_RS21540-MONOMER
GCF_001079465:ADV44_RS02080-MONOMER
GCF_001088345:AEZ18_RS22825-MONOMER
GCF_001095585:AD238_RS21695-MONOMER
GCF_001104165:AE704_RS21450-MONOMER
GCF_001104885:AEZ38_RS22140-MONOMER
GCF_001106745:AE121_RS02080-MONOMER
GCF_001118185:AE086_RS21440-MONOMER
GCF_001119245:AE140_RS21340-MONOMER
GCF_001121865:AE338_RS22285-MONOMER
GCF_001127485:AE735_RS21610-MONOMER
GCF_001135805:AEG73_RS21640-MONOMER
GCF_001148125:AEN24_RS00290-MONOMER
GCF_001148305:AEN67_RS04915-MONOMER
GCF_001157245:AER93_RS21680-MONOMER
GCF_001163025:AFA50_RS21895-MONOMER
GCF_001165785:AFA97_RS21420-MONOMER
GCF_001240865:ALC23_RS22685-MONOMER
GCF_001356455:AQJ76_RS21420-MONOMER
GCF_001357935:AQL34_RS16565-MONOMER
GCF_001359015:AQL50_RS16275-MONOMER
GCF_001360555:AQK88_RS21420-MONOMER
GCF_001361075:AQM75_RS02830-MONOMER
GCF_001362095:AQO19_RS03675-MONOMER
GCF_001362135:AQN73_RS04785-MONOMER
GCF_001362175:AQN68_RS21420-MONOMER
GCF_001362195:AQN87_RS09330-MONOMER
GCF_001362335:AQN99_RS04900-MONOMER
GCF_001364695:AQQ97_RS16885-MONOMER
GCF_900185485:CDZ80_RS02455-MONOMER

Family and domain databases

CDDicd02953 DsbDgamma, 1 hit
Gene3Di2.60.40.1250, 1 hit
3.40.30.10, 1 hit
HAMAPiMF_00399 DbsD, 1 hit
InterProiView protein in InterPro
IPR003834 Cyt_c_assmbl_TM_dom
IPR035671 DsbD_gamma
IPR028250 DsbDN
IPR036929 DsbDN_sf
IPR022910 Thiol_diS_interchange_DbsD
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR32234:SF0 PTHR32234:SF0, 1 hit
PfamiView protein in Pfam
PF11412 DsbC, 1 hit
PF02683 DsbD, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF74863 SSF74863, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSBD_SALTI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8Z1A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2002
Last modified: December 11, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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