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Protein

Urease accessory protein UreG 2

Gene

ureG2

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processNickel insertion
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreG 2UniRule annotation
Gene namesi
Name:ureG2UniRule annotation
Ordered Locus Names:BMEI0644
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473591 – 212Urease accessory protein UreG 2Add BLAST212

Proteomic databases

PRIDEiQ8YI01

Interactioni

Subunit structurei

Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_2619

Structurei

3D structure databases

ProteinModelPortaliQ8YI01
SMRiQ8YI01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UHB Bacteria
COG0378 LUCA
HOGENOMiHOG000236979
KOiK03189
OMAiGEKMPRK

Family and domain databases

HAMAPiMF_01389 UreG, 1 hit
InterProiView protein in InterPro
IPR003495 CobW/HypB/UreG_dom
IPR012202 NiFe-hyd/urease_mat_GTPase
IPR027417 P-loop_NTPase
IPR004400 UreG
PANTHERiPTHR31715 PTHR31715, 1 hit
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PIRSFiPIRSF005624 Ni-bind_GTPase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00101 ureG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YI01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIPRIGVG GPVGSGKTAI IEAVVPILIK LGYRILVITN DIVTTEDAKH
60 70 80 90 100
VQRTLKGVLI EDRIVGVETG GCPHTAVRED PSMNLAAVEE MEAKFPDTDL
110 120 130 140 150
VLLESGGDNL TLTFSPALID FFIYVIDVAA GDKIPRKNGP GISQSDILVI
160 170 180 190 200
NKTDLAPYVG ASLQVMDDDS RMMRGKKPFV FTNCKTNEGI DDLVHLIREN
210
VLFDTEVSKE SA
Length:212
Mass (Da):22,977
Last modified:March 1, 2002 - v1
Checksum:iC436DF98D5E8D12C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL51825.1
PIRiAF3332
RefSeqiWP_002964473.1, NZ_GG703780.1

Genome annotation databases

EnsemblBacteriaiAAL51825; AAL51825; BMEI0644
GeneIDi29593430
KEGGibme:BMEI0644
bmel:DK63_783
PATRICifig|224914.52.peg.820

Similar proteinsi

Entry informationi

Entry nameiUREG2_BRUME
AccessioniPrimary (citable) accession number: Q8YI01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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