UniProtKB - Q8YHW6 (Q8YHW6_BRUME)
Protein
Multifunctional fusion protein
Gene
secF
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Functioni
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
GO - Biological processi
- intracellular protein transmembrane transport Source: UniProtKB-UniRule
- protein targeting Source: UniProtKB-UniRule
- protein transport by the Sec complex Source: UniProtKB-UniRule
Keywordsi
Biological process | Protein transport, TranslocationUniRule annotationARBA annotation, Transport |
Enzyme and pathway databases
BioCyci | BMEL224914:G1FZL-725-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Multifunctional fusion proteinUniRule annotationIncluding the following 2 domains: Protein translocase subunit SecDUniRule annotation Protein-export membrane protein SecFUniRule annotation |
Gene namesi | Name:secFUniRule annotation Synonyms:secDUniRule annotation Ordered Locus Names:BMEI0680Imported |
Organismi | Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)Imported |
Taxonomic identifieri | 224914 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 27 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 372 – 399 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 411 – 437 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 458 – 483 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 495 – 518 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 548 – 566 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 666 – 685 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 692 – 713 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 719 – 736 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 768 – 789 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 801 – 823 | HelicalUniRule annotationAdd BLAST | 23 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membraneUniRule annotation, Cell membrane, MembraneInteractioni
Subunit structurei
Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
UniRule annotationForms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
UniRule annotationProtein-protein interaction databases
STRINGi | 224914.BMEI0680 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | COG0341, Bacteria COG0342, Bacteria |
OMAi | RTVNTGM |
Family and domain databases
HAMAPi | MF_01463_B, SecD_B, 1 hit MF_01464_B, SecF_B, 1 hit |
InterProi | View protein in InterPro IPR005791, SecD IPR022813, SecD/SecF_arch_bac IPR022645, SecD/SecF_bac IPR022646, SecD/SecF_CS IPR005665, SecF_bac |
PANTHERi | PTHR30081, PTHR30081, 2 hits |
Pfami | View protein in Pfam PF07549, Sec_GG, 2 hits PF02355, SecD_SecF, 2 hits |
PRINTSi | PR01755, SECFTRNLCASE |
TIGRFAMsi | TIGR00916, 2A0604s01, 2 hits TIGR00966, 3a0501s07, 1 hit TIGR01129, secD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8YHW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTSKWVVAL YSLVVLIGII IALPNFFTQK QLDALPSWLP KRQVTLGLDL
60 70 80 90 100
RGGSYLVLEV DAAALKKDRL RTLLDDARSK LRADRIQPQS IRVVGDAVVV
110 120 130 140 150
TIPDADQRAK AETALRTLIS QVNTSGFGTA INDIDVTEND NNQIRLTLTE
160 170 180 190 200
AGFNYRLDSA LQQSLEIIRQ RVDQVGVAEP SIQRVGSDRI VVQLPGLQDP
210 220 230 240 250
AQLRQLLGST AKMSFHMVAD ANPNDPPPPG VTIMPDSKNP AIKYPIEDQV
260 270 280 290 300
ALSGERLTDA RAGFDPRTNE PIVSFRFDSL GARQFADITT KNVNRPFAIV
310 320 330 340 350
LDGKVLSAPV IREPITGGSG QISGSFTVQD TVVLSALLRA GALPAPLTVI
360 370 380 390 400
EERTVGPDLG GDAIKMGLMT GIIGFLLVAV FILLLYGFWG VIANVALLLH
410 420 430 440 450
TLLTFSALSL IGATLTLPGI AGIILGIGIA VDANILINER IREETRKGLG
460 470 480 490 500
AMAALDKGFH SAFATIVDAN VTTLTATILL FLFGTGPVRG FAVTMMLGIA
510 520 530 540 550
ISMFTDVTLV RMIMAWFVRR RKLKVLHIEP FLKFVPEHTN FRFMNARFIG
560 570 580 590 600
IGVSIVLSIA SIILFFKPGL NYGIDFKGGI QAEISTSQPA DLAQLRAKLG
610 620 630 640 650
ALNLGEVALQ TAGSPNQVLI RVQRQEGGEE AQTAAINKMR EAVTELDPGV
660 670 680 690 700
KIERTEVVGP KVSGELARSG MIAVILSAVV MLFYIWWRFE WFFALGAIAT
710 720 730 740 750
LILDTTKIIG FFALTQLDFN LTAIAALLTI IGYSVNDKVV VYDRMRENMR
760 770 780 790 800
LYKSKTLREI IDMSINQVLV RCIYTSMTTF LCMFPMAIWG GSAVHNFAVP
810 820 830 840
MLFGIVIATS SSIFIAAPIL LLLGDWWQRH KAAHKTAEEG AIAQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008917 Genomic DNA Translation: AAL51861.1 |
PIRi | AB3337 |
RefSeqi | WP_004683969.1, NZ_GG703780.1 |
Genome annotation databases
EnsemblBacteriai | AAL51861; AAL51861; BMEI0680 |
GeneIDi | 29593467 |
KEGGi | bme:BMEI0680 bmel:DK63_750 |
PATRICi | fig|224914.52.peg.785 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE008917 Genomic DNA Translation: AAL51861.1 |
PIRi | AB3337 |
RefSeqi | WP_004683969.1, NZ_GG703780.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 224914.BMEI0680 |
Genome annotation databases
EnsemblBacteriai | AAL51861; AAL51861; BMEI0680 |
GeneIDi | 29593467 |
KEGGi | bme:BMEI0680 bmel:DK63_750 |
PATRICi | fig|224914.52.peg.785 |
Phylogenomic databases
eggNOGi | COG0341, Bacteria COG0342, Bacteria |
OMAi | RTVNTGM |
Enzyme and pathway databases
BioCyci | BMEL224914:G1FZL-725-MONOMER |
Family and domain databases
HAMAPi | MF_01463_B, SecD_B, 1 hit MF_01464_B, SecF_B, 1 hit |
InterProi | View protein in InterPro IPR005791, SecD IPR022813, SecD/SecF_arch_bac IPR022645, SecD/SecF_bac IPR022646, SecD/SecF_CS IPR005665, SecF_bac |
PANTHERi | PTHR30081, PTHR30081, 2 hits |
Pfami | View protein in Pfam PF07549, Sec_GG, 2 hits PF02355, SecD_SecF, 2 hits |
PRINTSi | PR01755, SECFTRNLCASE |
TIGRFAMsi | TIGR00916, 2A0604s01, 2 hits TIGR00966, 3a0501s07, 1 hit TIGR01129, secD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8YHW6_BRUME | |
Accessioni | Q8YHW6Primary (citable) accession number: Q8YHW6 Secondary accession number(s): D0B8U3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |