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Protein

Homoserine kinase

Gene

thrB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (BMEI0189)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (BMEI0725)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMEL224914:G1FZL-1568-MONOMER
UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:BMEI1458
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001721861 – 326Homoserine kinaseAdd BLAST326

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0765

Structurei

3D structure databases

ProteinModelPortaliQ8YFR2
SMRiQ8YFR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUV Bacteria
COG2334 LUCA
HOGENOMiHOG000004810
KOiK02204
OMAiAGALRFW

Family and domain databases

CDDicd05153 HomoserineK_II, 1 hit
HAMAPiMF_00301 Homoser_kinase_2, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR005280 Homoserine_kinase_II
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR00938 thrB_alt, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YFR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL
60 70 80 90 100
TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA
110 120 130 140 150
IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP
160 170 180 190 200
LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF
210 220 230 240 250
FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG
260 270 280 290 300
YTSVRPLSEA EANALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME
310 320
YVRRMRFHRQ IESGAEYGLE MQGVAA
Length:326
Mass (Da):36,630
Last modified:March 1, 2002 - v1
Checksum:i0BE3E69B6AC11AF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL52639.1
PIRiAD3434
RefSeqiWP_004683140.1, NZ_GG703778.1

Genome annotation databases

EnsemblBacteriaiAAL52639; AAL52639; BMEI1458
GeneIDi29594311
KEGGibme:BMEI1458
bmel:DK63_2029
PATRICifig|224914.52.peg.2131

Similar proteinsi

Entry informationi

Entry nameiKHSE_BRUME
AccessioniPrimary (citable) accession number: Q8YFR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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