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UniProtKB - Q8Y9K8 (LMRB_LISMO)
Protein
Lincomycin resistance protein LmrB
Gene
lmrB
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Functioni
Proton-dependent transporter. May mediate the efflux of lincomycin (By similarity).
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Lincomycin resistance protein LmrB |
Gene namesi | Name:lmrB Ordered Locus Names:lmo0519 |
Organismi | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) |
Taxonomic identifieri | 169963 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 35 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 55 – 77 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 84 – 106 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 111 – 133 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 140 – 162 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 167 – 189 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 201 – 223 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 227 – 249 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 269 – 291 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 329 – 351 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 358 – 380 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 445 – 467 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173330 | 1 – 471 | Lincomycin resistance protein LmrBAdd BLAST | 471 |
Proteomic databases
PaxDbi | Q8Y9K8 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_000960_28_0_9 |
OMAi | SGLVVHW |
PhylomeDBi | Q8Y9K8 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8Y9K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQEATGGQK IRPIPIIASF LMAGFIGLFS ETALNMALSD LIQVFDISSA
60 70 80 90 100
TVQWLTTGYL LTLGILVPIS GLLLQWFTTR GLFFTAVSFS IAGTLIAALS
110 120 130 140 150
PTFAMLMIGR VVQAVGTALL LPLMFNTILL IFPEHKRGSA MGMIGLVIMF
160 170 180 190 200
APAVGPTISG LILENLTWNW IFWISLPFLI IALLFGMKFM QNVSVVTKPK
210 220 230 240 250
IDILSIILST LGFGGVVFAF SSAGESGWGS ATVLVSIIVG GIALGLFVWR
260 270 280 290 300
QLTMEKPLMD LKVFKYPMFT LGLILVFISF MMILSTMILL PLYLQNSLAL
310 320 330 340 350
AAFSAGLVLL PGGVLNGLMS PFTGRLFDAY GPRALVIPGF IVAVVALFFL
360 370 380 390 400
TRIEVGTSAL TIIVLHSVLM IGISMVMMPA QTNGLNQLPP KLYPDGTAIM
410 420 430 440 450
NTLQQVSGAI GTAVAITIMS AGQKAYMETA QGVGPEQMVA SLTAGIQNAF
460 470
VFGLIMACIG LLCSLFIRKA K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591975 Genomic DNA Translation: CAC98598.1 |
PIRi | AH1139 |
RefSeqi | NP_464047.1, NC_003210.1 WP_009931218.1, NZ_CP023861.1 |
Genome annotation databases
EnsemblBacteriai | CAC98598; CAC98598; CAC98598 |
GeneIDi | 985272 |
KEGGi | lmo:lmo0519 |
PATRICi | fig|169963.11.peg.538 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591975 Genomic DNA Translation: CAC98598.1 |
PIRi | AH1139 |
RefSeqi | NP_464047.1, NC_003210.1 WP_009931218.1, NZ_CP023861.1 |
3D structure databases
SMRi | Q8Y9K8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 169963.lmo0519 |
Proteomic databases
PaxDbi | Q8Y9K8 |
Genome annotation databases
EnsemblBacteriai | CAC98598; CAC98598; CAC98598 |
GeneIDi | 985272 |
KEGGi | lmo:lmo0519 |
PATRICi | fig|169963.11.peg.538 |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_000960_28_0_9 |
OMAi | SGLVVHW |
PhylomeDBi | Q8Y9K8 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LMRB_LISMO | |
Accessioni | Q8Y9K8Primary (citable) accession number: Q8Y9K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families