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Protein

Imidazole glycerol phosphate synthase subunit HisF

Gene

hisF

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).By similarity

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Sequence analysis1
Active sitei130Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciLMON169963:LMO0563-MONOMER
UniPathwayi
UPA00031;UER00010

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisF (EC:4.1.3.-)
Alternative name(s):
IGP synthase cyclase subunit
IGP synthase subunit HisF
ImGP synthase subunit HisF
Short name:
IGPS subunit HisF
Gene namesi
Name:hisF
Ordered Locus Names:lmo0563
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001421781 – 251Imidazole glycerol phosphate synthase subunit HisFAdd BLAST251

Proteomic databases

PaxDbiQ8Y9G5
PRIDEiQ8Y9G5

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.By similarity

Protein-protein interaction databases

STRINGi169963.lmo0563

Structurei

3D structure databases

ProteinModelPortaliQ8Y9G5
SMRiQ8Y9G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

eggNOGiENOG4105C0S Bacteria
COG0107 LUCA
HOGENOMiHOG000224612
KOiK02500
OMAiKRIVPCL
PhylomeDBiQ8Y9G5

Family and domain databases

CDDicd04731 HisF, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01013 HisF, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR004651 HisF
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00735 hisF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y9G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTKRIIPCL DVTAGRVVKG VNFVSLTDVG DPVEIAKAYN EAGADELVFL
60 70 80 90 100
DITATVELRQ TMIDVVERTA EQVFIPLTVG GGISSVSDMK ELLQAGADKI
110 120 130 140 150
SLNSAAIKRP ELIQEGAAKF GNQCIVVAID AKWNGTNWSV FTRGGRNDTG
160 170 180 190 200
LDAIEWAKKA VQLGAGEILL TSMDGDGTKN GYDIPLTKAI SEAVSVPVIA
210 220 230 240 250
SGGCGNAAHM VEVFEKTKAT AALAASIFHY GELSIKNVKT TLLEKGVNIR

P
Length:251
Mass (Da):26,533
Last modified:March 1, 2002 - v1
Checksum:iAFE142080F39C67D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591975 Genomic DNA Translation: CAC98642.1
PIRiAD1145
RefSeqiNP_464091.1, NC_003210.1
WP_010989517.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC98642; CAC98642; CAC98642
GeneIDi984515
KEGGilmo:lmo0563
PATRICifig|169963.11.peg.582

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591975 Genomic DNA Translation: CAC98642.1
PIRiAD1145
RefSeqiNP_464091.1, NC_003210.1
WP_010989517.1, NC_003210.1

3D structure databases

ProteinModelPortaliQ8Y9G5
SMRiQ8Y9G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo0563

Proteomic databases

PaxDbiQ8Y9G5
PRIDEiQ8Y9G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98642; CAC98642; CAC98642
GeneIDi984515
KEGGilmo:lmo0563
PATRICifig|169963.11.peg.582

Phylogenomic databases

eggNOGiENOG4105C0S Bacteria
COG0107 LUCA
HOGENOMiHOG000224612
KOiK02500
OMAiKRIVPCL
PhylomeDBiQ8Y9G5

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00010

BioCyciLMON169963:LMO0563-MONOMER

Family and domain databases

CDDicd04731 HisF, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01013 HisF, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR004651 HisF
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00735 hisF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIS6_LISMO
AccessioniPrimary (citable) accession number: Q8Y9G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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