Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei596For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciLMON169963:LMO0727-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:lmo0727
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353532 – 601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST600

Proteomic databases

PaxDbiQ8Y915

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo0727

Structurei

3D structure databases

ProteinModelPortaliQ8Y915
SMRiQ8Y915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 216Glutamine amidotransferase type-2UniRule annotationAdd BLAST215
Domaini282 – 421SIS 1UniRule annotationAdd BLAST140
Domaini453 – 591SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
PhylomeDBiQ8Y915

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Y915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGYIGT NNAKGILLEG LEKLEYRGYD SAGIALQNKE LVTVVKEKGR
60 70 80 90 100
IADLASLVPS DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTIVHNG
110 120 130 140 150
VIENYTLLKE EYLKNHSFVS DTDTEVIVQL IELFAAELST KEAFKKALSL
160 170 180 190 200
LHGSYAICLI DQTNTETLYA AKNKSPLLIG KGENFNVIAS DAMAVLKETD
210 220 230 240 250
EFVEIMDKEI VIVTKDGFTL ETLEGEEITR ASYKAELDAS DIEKGTYPHY
260 270 280 290 300
MLKEIDEQPA VTRKIIQAYQ DEAGEINVDK TIIDEILSSD RIHIVACGTS
310 320 330 340 350
YHAGLVGKNL IEKMAKIPVE VHVSSEFAYN LPLMSKKPLF IFITQSGETA
360 370 380 390 400
DSRQCLVKVK ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA
410 420 430 440 450
YTAQISVLAV LAVSLGREIG DEEALNINLA AELGIVATAM EAMVSSKEVI
460 470 480 490 500
EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA LKLKEISYIQ AEGFASGELK
510 520 530 540 550
HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT CIFAMENVAQ
560 570 580 590 600
PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV

E
Length:601
Mass (Da):65,767
Last modified:January 23, 2007 - v3
Checksum:iCE9182743475C273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591976 Genomic DNA Translation: CAC98805.1
PIRiAG1165
RefSeqiNP_464254.1, NC_003210.1
WP_010989553.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC98805; CAC98805; CAC98805
GeneIDi986353
KEGGilmo:lmo0727
PATRICifig|169963.11.peg.749

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591976 Genomic DNA Translation: CAC98805.1
PIRiAG1165
RefSeqiNP_464254.1, NC_003210.1
WP_010989553.1, NC_003210.1

3D structure databases

ProteinModelPortaliQ8Y915
SMRiQ8Y915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo0727

Proteomic databases

PaxDbiQ8Y915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98805; CAC98805; CAC98805
GeneIDi986353
KEGGilmo:lmo0727
PATRICifig|169963.11.peg.749

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
PhylomeDBiQ8Y915

Enzyme and pathway databases

BioCyciLMON169963:LMO0727-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_LISMO
AccessioniPrimary (citable) accession number: Q8Y915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again