lexA

Functionⁱ

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityⁱ

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	126	For autocatalytic cleavage activityUniRule annotation		1
Active siteⁱ	164	For autocatalytic cleavage activityUniRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	27 – 47	H-T-H motifUniRule annotationAdd BLAST		21

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA repair Source: UniProtKB-KW
DNA replication Source: UniProtKB-KW
negative regulation of transcription, DNA-templated
Source: CollecTF
Inferred from experimentⁱ
- 19892760
SOS response
Source: CollecTF
Inferred from experimentⁱ
- 19892760
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Hydrolase, Repressor
Biological process	DNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	LMON169963:LMO1302-MONOMER

BioCycⁱ

LMON169963:LMO1302-MONOMER

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S24.001

MEROPSⁱ

S24.001

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesⁱ	Name:lexAUniRule annotation Ordered Locus Names:lmo1302
Organismⁱ	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifierⁱ	169963 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes
Proteomesⁱ	UP000000817 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000170053	1 – 204	LexA repressorAdd BLAST		204

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	90 – 91	Cleavage; by autolysisUniRule annotation		2

Keywords - PTMⁱ

Autocatalytic cleavage

Proteomic databases

PaxDbⁱ	Q8Y7H7

PaxDbⁱ

Q8Y7H7

Expressionⁱ

Gene expression databases

CollecTFⁱ	EXPREG_000013e0

CollecTFⁱ

EXPREG_000013e0

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	169963.lmo1302

STRINGⁱ

169963.lmo1302

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8Y7H7
SMRⁱ	Q8Y7H7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105DS7 Bacteria COG1974 LUCA
HOGENOMⁱ	HOG000232168
KEGG Orthology (KO) More...KOⁱ	K01356
OMAⁱ	RQMMQAM
PhylomeDBⁱ	Q8Y7H7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00090 HTH_ARSR, 1 hit cd06529 S24_LexA-like, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
HAMAPⁱ	MF_00015 LexA, 1 hit
InterProⁱ	View protein in InterPro IPR011991 ArsR-like_HTH IPR006200 LexA IPR039418 LexA-like IPR036286 LexA/Signal_pep-like_sf IPR006199 LexA_DNA-bd_dom IPR006197 Peptidase_S24_LexA IPR015927 Peptidase_S24_S26A/B/C IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01726 LexA_DNA_bind, 1 hit PF00717 Peptidase_S24, 1 hit
PRINTSⁱ	PR00726 LEXASERPTASE
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF51306 SSF51306, 1 hit
TIGRFAMsⁱ	TIGR00498 lexA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8Y7H7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKISKRQQDI YEFIKSEVKE KGYPPSVREI GEAVGLASSS TVHGHLARLE 
        60         70         80         90        100
GKGLIRRDPT KPRAIEILSL EDEAETPNVV NIPIIGKVTA GMPITAIENI 
       110        120        130        140        150
DEYFPLPEYM AAGETNVFML EIDGESMINA GILDGDKVIV RQESSAINGE 
       160        170        180        190        200
IVVAMTDENE ATCKRFYKEA NHFRLQPEND ALEPILLNNV TILGKVIGLY 

RDIR

Length:204

Mass (Da):22,638

Last modified:March 1, 2002 - v1

Checksum:ⁱ05DBADBEC089F313

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL591978 Genomic DNA Translation: CAC99380.1
PIRⁱ	AF1237
NCBI Reference Sequences More...RefSeqⁱ	NP_464827.1, NC_003210.1 WP_009930693.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaⁱ	CAC99380; CAC99380; CAC99380
GeneIDⁱ	985139
KEGGⁱ	lmo:lmo1302
PATRICⁱ	fig\|169963.11.peg.1338

Protein	Similar proteins		Species	Score	Length	Source
Q8Y7H7	LexA repressor		LISIN		204	UniRef90_Q8Y7H7
LexA repressor		LISMC		204
LexA repressor		LISMF		204
LexA repressor		LISMH		204
LexA repressor		LISW6		204
+25

Protein	Similar proteins		Species	Score	Length	Source
Q8Y7H7	LexA repressor		BACSU		205	UniRef50_P31080
LexA repressor		BACLD		207
LexA repressor		BACVZ		206
LexA repressor		ALKMQ		206
LexA repressor		STAS1		207
+1754

Entry informationⁱ

Entry nameⁱ	LEXA_LISMO
Accessionⁱ	Q8Y7H7Primary (citable) accession number: Q8Y7H7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q8Y7H7 (LEXA_LISMO)

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LexA repressor

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Functionⁱ

Catalytic activityⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Sites

Keywords - PTMⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8Y7H7 (LEXA_LISMO)

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LexA repressor

lexA

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Sites

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ