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UniProtKB - Q8Y7H7 (LEXA_LISMO)
Protein
LexA repressor
Gene
lexA
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Functioni
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
UniRule annotationCatalytic activityi
- Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation EC:3.4.21.88
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 126 | For autocatalytic cleavage activityUniRule annotation | 1 | |
Active sitei | 164 | For autocatalytic cleavage activityUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 27 – 47 | H-T-H motifUniRule annotationAdd BLAST | 21 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- serine-type endopeptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA repair Source: UniProtKB-UniRule
- DNA replication Source: UniProtKB-UniRule
- negative regulation of transcription, DNA-templated Source: CollecTF
- SOS response Source: CollecTF
Keywordsi
Molecular function | DNA-binding, Hydrolase, Repressor |
Biological process | DNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation |
Protein family/group databases
MEROPSi | S24.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lexAUniRule annotation Ordered Locus Names:lmo1302 |
Organismi | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) |
Taxonomic identifieri | 169963 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000170053 | 1 – 204 | LexA repressorAdd BLAST | 204 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 90 – 91 | Cleavage; by autolysisUniRule annotation | 2 |
Keywords - PTMi
Autocatalytic cleavageProteomic databases
PaxDbi | Q8Y7H7 |
PRIDEi | Q8Y7H7 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 169963.lmo1302 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S24 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1974, Bacteria |
HOGENOMi | CLU_066192_45_1_9 |
OMAi | HVWLLPH |
PhylomeDBi | Q8Y7H7 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit cd06529, S24_LexA-like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00015, LexA, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR006200, LexA IPR039418, LexA-like IPR036286, LexA/Signal_pep-like_sf IPR006199, LexA_DNA-bd_dom IPR006197, Peptidase_S24_LexA IPR015927, Peptidase_S24_S26A/B/C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01726, LexA_DNA_bind, 1 hit PF00717, Peptidase_S24, 1 hit |
PRINTSi | PR00726, LEXASERPTASE |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR00498, lexA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8Y7H7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKISKRQQDI YEFIKSEVKE KGYPPSVREI GEAVGLASSS TVHGHLARLE
60 70 80 90 100
GKGLIRRDPT KPRAIEILSL EDEAETPNVV NIPIIGKVTA GMPITAIENI
110 120 130 140 150
DEYFPLPEYM AAGETNVFML EIDGESMINA GILDGDKVIV RQESSAINGE
160 170 180 190 200
IVVAMTDENE ATCKRFYKEA NHFRLQPEND ALEPILLNNV TILGKVIGLY
RDIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591978 Genomic DNA Translation: CAC99380.1 |
PIRi | AF1237 |
RefSeqi | NP_464827.1, NC_003210.1 WP_009930693.1, NZ_CP023861.1 |
Genome annotation databases
EnsemblBacteriai | CAC99380; CAC99380; CAC99380 |
GeneIDi | 985139 |
KEGGi | lmo:lmo1302 |
PATRICi | fig|169963.11.peg.1338 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591978 Genomic DNA Translation: CAC99380.1 |
PIRi | AF1237 |
RefSeqi | NP_464827.1, NC_003210.1 WP_009930693.1, NZ_CP023861.1 |
3D structure databases
SMRi | Q8Y7H7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 169963.lmo1302 |
Protein family/group databases
MEROPSi | S24.001 |
Proteomic databases
PaxDbi | Q8Y7H7 |
PRIDEi | Q8Y7H7 |
Genome annotation databases
EnsemblBacteriai | CAC99380; CAC99380; CAC99380 |
GeneIDi | 985139 |
KEGGi | lmo:lmo1302 |
PATRICi | fig|169963.11.peg.1338 |
Phylogenomic databases
eggNOGi | COG1974, Bacteria |
HOGENOMi | CLU_066192_45_1_9 |
OMAi | HVWLLPH |
PhylomeDBi | Q8Y7H7 |
Gene expression databases
CollecTFi | EXPREG_000013e0 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit cd06529, S24_LexA-like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00015, LexA, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR006200, LexA IPR039418, LexA-like IPR036286, LexA/Signal_pep-like_sf IPR006199, LexA_DNA-bd_dom IPR006197, Peptidase_S24_LexA IPR015927, Peptidase_S24_S26A/B/C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01726, LexA_DNA_bind, 1 hit PF00717, Peptidase_S24, 1 hit |
PRINTSi | PR00726, LEXASERPTASE |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR00498, lexA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LEXA_LISMO | |
Accessioni | Q8Y7H7Primary (citable) accession number: Q8Y7H7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families