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Entry version 106 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Lmo2446 protein

Gene

lmo2446

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36GlucoseCombined sources1
Binding sitei82GlucoseCombined sources1
Binding sitei133Glucose; via carbonyl oxygenCombined sources1
Binding sitei400GlucoseCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi401Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi403Magnesium 1Combined sources1
Metal bindingi407Magnesium 1Combined sources1
Binding sitei440GlucoseCombined sources1
Binding sitei444GlucoseCombined sources1
Binding sitei449GlucoseCombined sources1
Binding sitei468GlucoseCombined sources1
Binding sitei490GlucoseCombined sources1
Binding sitei504GlucoseCombined sources1
Binding sitei528GlucoseCombined sources1
Binding sitei565GlucoseCombined sources1
Binding sitei614GlucoseCombined sources1
Binding sitei630GlucoseCombined sources1
Binding sitei665Glucose; via amide nitrogenCombined sources1
Binding sitei805GlucoseCombined sources1
Metal bindingi970CalciumCombined sources1
Metal bindingi970Magnesium 2Combined sources1
Metal bindingi972CalciumCombined sources1
Metal bindingi972Magnesium 2Combined sources1
Binding sitei976Glucose; via amide nitrogenCombined sources1
Binding sitei985GlucoseCombined sources1
Metal bindingi989Calcium; via carbonyl oxygenCombined sources1
Metal bindingi989Magnesium 2; via carbonyl oxygenCombined sources1
Binding sitei991GlucoseCombined sources1
Metal bindingi992Calcium; via carbonyl oxygenCombined sources1
Metal bindingi992Magnesium 2; via carbonyl oxygenCombined sources1
Binding sitei996Glucose; via amide nitrogenCombined sources1
Binding sitei1028GlucoseCombined sources1
Binding sitei1051GlucoseCombined sources1
Metal bindingi1085CalciumCombined sources1
Metal bindingi1085Magnesium 2Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
LigandCalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
LMON169963:LMO2446-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM35, Carbohydrate-Binding Module Family 35
GH31, Glycoside Hydrolase Family 31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lmo2446 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:lmo2446Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri169963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000817 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500431726732 – 1091Sequence analysisAdd BLAST1060

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8Y4J2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
169963.lmo2446

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8Y4J2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1090CBM6InterPro annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni71 – 78Glucose bindingCombined sources8
Regioni92 – 97Glucose bindingCombined sources6
Regioni103 – 104Glucose bindingCombined sources2
Regioni301 – 303Glucose bindingCombined sources3
Regioni428 – 436Glucose bindingCombined sources9
Regioni496 – 498Glucose bindingCombined sources3
Regioni689 – 691Glucose bindingCombined sources3
Regioni798 – 801Glucose bindingCombined sources4
Regioni813 – 814Glucose bindingCombined sources2
Regioni1081 – 1083Glucose bindingCombined sources3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1501, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_293000_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQWKAFT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8Y4J2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
2.60.40.10, 1 hit
2.60.40.1180, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005084, CMB_fam6
IPR032513, DUF4968
IPR011013, Gal_mutarotase_sf_dom
IPR008979, Galactose-bd-like_sf
IPR000322, Glyco_hydro_31
IPR025887, Glyco_hydro_31_N_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16990, CBM_35, 1 hit
PF16338, DUF4968, 1 hit
PF13802, Gal_mutarotas_2, 1 hit
PF01055, Glyco_hydro_31, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit
SSF74650, SSF74650, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51175, CBM6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8Y4J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRRTRKCSL VFILGILIFS CLSGFGTNVF AMDGEYHSPY GDDDLYTVQP
60 70 80 90 100
TERSPRDPKA GEDVILNITT WPIENGQDVW VEWTKNGVAQ ENVTAAYDYN
110 120 130 140 150
SGNNTYWKAD LGKFEKGDEI TYTTKGSTNG GTAYESGPFT FYVTDWEYVQ
160 170 180 190 200
DVTSVVDNGD SITLNMTATA GDFSPKLYLS FEDLDTLRME LSPTGKETGH
210 220 230 240 250
AGKSGYTVED TAEKVTVTTE DLSIEIQKSP YRMEVHQADG TLLTSEYTTA
260 270 280 290 300
NSLGWLTDGK NVINQYQNNF MTPSDEAFYG FGERYDTINQ RGKDVETYVY
310 320 330 340 350
NEYQDQAQTE RTYLAVPFFV SANKYGMYVN SDFHSQFQMA SKVEDKYSFV
360 370 380 390 400
LDNDGDMTNM LDYYVISGKD QNDIVNNYTD ITGKTTLLPK WAFGLWMSAN
410 420 430 440 450
EWDRESDVSS ALSNAKANDI PATGFVLEQW SDEETYYIWN NATYTAKKNG
460 470 480 490 500
EAFSYDDFTF NGKWTDPKGM VDSVHDAGMN IVLWQVPVLK DDGTVYEQRD
510 520 530 540 550
NDEEYMISQG YSADDGTGAP YRVPASQWFG NGILLDFTNK DAVDWWTSQR
560 570 580 590 600
EYLLTEVGID GFKTDGGEMV WGRDTTFSNG EKGQEMRNRY PTDYVSSYFD
610 620 630 640 650
FAKSINPEAV SFSRSGTSGA QKSGIYWSGD QTSTFDSFQA SLKAGLSAST
660 670 680 690 700
SGVSYWAWDM AGFTGDYPTA ELYKRATAMA AFAPIMQFHS EKSDPSPSEE
710 720 730 740 750
RSPWNAVART GDETILPTFQ KYLYTRMNLL PYIYTAAKDT ADNGKSMMRQ
760 770 780 790 800
MAMDYPEDVN ARDLDEQYMF GDDLLVAPIV QEGQTEKEVY LPEGEWVDIW
810 820 830 840 850
NGGVHPGGET ISYYADVDTL PVFAKAGAII PMNMTDGYQL GQNVGNDLKS
860 870 880 890 900
YDNLTFRVYP SGDSEYSFYD DVNGGEMRDI SVSEDFANEK VSVDLPAMAD
910 920 930 940 950
ETTMQVFSTE PTSVTIDGAD VAKADTLDAF NEATTGYYYD TVQNLTYVKA
960 970 980 990 1000
AAKDAKQAIV LNGVNHAPYE AEFGHLTNVT TASDHAGYTG TGFVAGFDAE
1010 1020 1030 1040 1050
KEAVEFDIDA VDGASDYTME VRYSAGVEDA TRTVYINGKK QQITLPKTAN
1060 1070 1080 1090
WDTWNTVEVP VTLQAGNNQV VFDFEADDTA GINFDHVVIK K
Length:1,091
Mass (Da):121,698
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55FC3969F472DCDE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591983 Genomic DNA Translation: CAD00524.1

Protein sequence database of the Protein Information Resource

More...
PIRi
AF1380

NCBI Reference Sequences

More...
RefSeqi
NP_465969.1, NC_003210.1
WP_010989995.1, NZ_CP023861.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAD00524; CAD00524; CAD00524

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47225857
987393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lmo:lmo2446

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|169963.11.peg.2505

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA Translation: CAD00524.1
PIRiAF1380
RefSeqiNP_465969.1, NC_003210.1
WP_010989995.1, NZ_CP023861.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KMQX-ray1.90A32-1091[»]
4KWUX-ray1.90A32-1091[»]
5F7UX-ray1.70A31-1091[»]
5HPOX-ray1.80A31-1091[»]
5HXMX-ray1.90A31-1091[»]
5I0DX-ray1.77A/B31-1091[»]
SMRiQ8Y4J2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2446

Protein family/group databases

CAZyiCBM35, Carbohydrate-Binding Module Family 35
GH31, Glycoside Hydrolase Family 31

Proteomic databases

PaxDbiQ8Y4J2

Genome annotation databases

EnsemblBacteriaiCAD00524; CAD00524; CAD00524
GeneIDi47225857
987393
KEGGilmo:lmo2446
PATRICifig|169963.11.peg.2505

Phylogenomic databases

eggNOGiCOG1501, Bacteria
HOGENOMiCLU_293000_0_0_9
OMAiLQWKAFT
PhylomeDBiQ8Y4J2

Enzyme and pathway databases

BioCyciLMON169963:LMO2446-MONOMER

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR005084, CMB_fam6
IPR032513, DUF4968
IPR011013, Gal_mutarotase_sf_dom
IPR008979, Galactose-bd-like_sf
IPR000322, Glyco_hydro_31
IPR025887, Glyco_hydro_31_N_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF16990, CBM_35, 1 hit
PF16338, DUF4968, 1 hit
PF13802, Gal_mutarotas_2, 1 hit
PF01055, Glyco_hydro_31, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit
SSF74650, SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS51175, CBM6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8Y4J2_LISMO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8Y4J2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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